4 research outputs found
Response of central nervous system aspergillosis to voriconazole
Fungal infections of the central nervous system (CNS) usually present
as subacute meningitis. Other manifestations include mass effect and
focal neurological deficits. [1] Cerebrospinal fluid (CSF) examination
and biopsy of the lesion are helpful in disclosing the organism
involved. Aspergillosis presents as brain abscess or granuloma with
predominant neutrophils in CSF. Voriconazole is a broad spectrum
triazole antifungal agent. It can be given orally and has lesser
adverse effects We report a 69-years-old diabetic male, with
aspergilloma of para-nasal sinus invading the CNS, who responded well
to voriconazole treatment. He discontinued the medication by himself as
it was costly. Within a month of stopping the medication, he developed
features of subacute meningitis. However he showed clinical improvement
after the medication was restarted. The case is reported for the
clinical evidence of antifungal activity of voriconazole against
aspergillosis