Period-tripling subharmonic oscillations in a driven superconducting resonator

We have observed period-tripling subharmonic oscillations, in a superconducting coplanar waveguide resonator operated in the quantum regime, $k_B T \ll \hbar\omega$. The resonator is terminated by a tunable inductance that provides a Kerr-type nonlinearity. We detected the output field quadratures at frequencies near the fundamental mode, $\omega/2\pi \sim 5\,$GHz, when the resonator was driven by a current at $3\omega$ with an amplitude exceeding an instability threshold. The output radiation was red-detuned from the fundamental mode. We observed three stable radiative states with equal amplitudes and phase-shifted by $120^\circ$. The downconversion from $3\omega$ to $\omega$ is strongly enhanced by resonant excitation of the second mode of the resonator, and the cross-Kerr effect. Our experimental results are in quantitative agreement with a model for the driven dynamics of two coupled modes

Chromatic interaction between egg pigmentation and skin chromatophores in the nuptial coloration of female two-spotted gobies

In two-spotted gobies (Gobiusculus flavescens Fabricius 1779), females develop an orange belly as they approach sexual maturity. Bright belly coloration is preferred by males and has been suggested to act as a female ornament. This coloration is unusual in that it originates partly from pigmentation of the abdominal skin but also from strongly pigmented gonads directly visible through the skin. In addition, females have been observed to temporarily become more colourful during courtship and competition. To understand how gonad and skin pigmentation interact in this nuptial coloration, the potential for colour modification via regulation of skin chromatophores was investigated. Noradrenaline caused aggregation of chromatophore pigment and was used to experimentally reduce the contribution of skin chromatophores to the nuptial coloration. Chromatophore pigment aggregation caused bellies to become less colourful and abdominal skin biopsies to become less colourful and more transparent. There was a strong positive relationship between belly coloration and the coloration of the underlying gonads. This shows that belly coloration honestly reflects egg pigmentation, mainly because the transparency of the abdominal skin allows other fish to see the gonads directly. Interestingly, when noradrenaline caused pigment to aggregate and thereby increased the transparency of the skin, the relationship between belly and gonad coloration weakened. We conclude that female G. flavescens have a potential to use skin chromatophores to rapidly alter their nuptial coloration, thereby affecting the efficacy with which information about gonad coloration is conveyed. <br /

Period multiplication in a parametrically driven superconducting resonator

We report on the experimental observation of period multiplication in parametrically driven tunable superconducting resonators. We modulate the magnetic flux through a superconducting quantum interference device, attached to a quarter-wavelength resonator, with frequencies $n\omega$ close to multiples, $n=2,\,3,\,4,\,5$, of the resonator fundamental mode and observe intense output radiation at $\omega$. The output field manifests $n$-fold degeneracy with respect to the phase, the $n$ states are phase shifted by $2\pi/n$ with respect to each other. Our demonstration verifies the theoretical prediction by Guo et al. in PRL 111, 205303 (2013), and paves the way for engineering complex macroscopic quantum cat states with microwave photons

Microwave photon generation in a doubly tunable superconducting resonator

We have developed and tested a doubly tunable resonator, with the intention to simulate fast motion of the resonator boundaries in real space. Our device is a superconducting coplanar-waveguide half-wavelength microwave resonator, with fundamental resonant frequency ~5 GHz. Both of its ends are terminated by dc-SQUIDs, which serve as magnetic-flux-controlled inductances. Applying a flux to either SQUID allows tuning of the resonant frequency by approximately 700 MHz. By using two separate on-chip magnetic-flux lines, we modulate the SQUIDs with two tones of equal frequency, close to twice that of the resonator's fundamental mode. We observe photon generation, at the fundamental frequency, above a certain pump amplitude threshold. By varying the relative phase of the two pumps we are able to control the photon generation threshold, in good agreement with a theoretical model for the modulation of the boundary conditions. At the same time, some of our observations deviate from the theoretical predictions, which we attribute to parasitic couplings, resulting in current driving of the SQUIDs.Comment: 7 pages, 4 figure

Observation of Broadband Entanglement in Microwave Radiation from a Single Time-Varying Boundary Condition

Entangled pairs of microwave photons are commonly produced in the narrow frequency band of a resonator, which represents a modified vacuum density of states. We generate and investigate the entanglement of a stream of photon pairs, generated in a semi-infinite broadband transmission line, terminated by a superconducting quantum interference device (SQUID). A weak pump signal modulates the SQUID inductance, resulting in a single time-varying boundary condition, and we detect all four quadratures of the microwave radiation emitted at two different frequencies separated by 0.7\ua0GHz. Power calibration is done\ua0in\ua0situ, and we find positive logarithmic negativity and two-mode squeezing below the vacuum in the observed radiation, indicating entanglement

Nondegenerate parametric oscillations in a tunable superconducting resonator

We investigate nondegenerate parametric oscillations in a multimode superconducting microwave resonator that is terminated by a SQUID. The parametric effect is achieved by modulating magnetic flux through the SQUID at a frequency close to the sum of two resonator-mode frequencies. For modulation amplitudes exceeding an instability threshold, self-sustained oscillations are observed in both modes. The amplitudes of these oscillations show good quantitative agreement with a theoretical model. The oscillation phases are found to be correlated and exhibit strong fluctuations which broaden the oscillation spectral linewidths. These linewidths are significantly reduced by applying a weak on-resonance tone, which also suppresses the phase fluctuations. When the weak tone is detuned, we observe synchronization of the oscillation frequency with the frequency of the input. For the detuned input, we also observe an emergence of three idlers in the output. This observation is in agreement with theory indicating four-mode amplification and squeezing of a coherent input.Comment: 7 pages, 8 figure

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

Background: Exercise may activate a brown adipose-like phenotype in white adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) and fibronectin type III domain-containing protein 5 (FNDC5) in muscle, circulating Irisin and uncoupling protein one (UCP1) of white adipocytes in humans. Methods: Two databases (PubMed 1966 to 08/2016 and EMBASE 1974 to 08/2016) were searched using an appropriate algorithm. We included articles that examined physical activity and/or exercise in humans that met the following criteria: a) PGC-1a in conjunction with FNDC5 measurements, and b) FNDC5 and/or circulating Irisin and/or UCP1 levels in white adipocytes. Results: We included 51 studies (12 randomised controlled trials) with 2474 participants. Out of the 51 studies, 16 examined PGC-1a and FNDC5 in response to exercise, and only four found increases in both PGC-1a and FNDC5 mRNA and one showed increased FNDC5 mRNA. In total, 22 out of 45 studies that examined circulating Irisin in response to exercise showed increased concentrations when ELISA techniques were used; two studies also revealed increased Irisin levels measured via mass spectrometry. Three studies showed a positive association of circulating Irisin with physical activity levels. One study found no exercise effects on UCP1 mRNA in white adipocytes. Conclusions: The effects of physical activity on the link between PGC-1a, FNDC5 mRNA in muscle and UCP1 in white human adipocytes has attracted little scientific attention. Current methods for Irisin identification lack precision and, therefore, the existing evidence does not allow for conclusions to be made regarding Irisin responses to physical activity. We found a contrast between standardised review methods and accuracy of the measurements used. This should be considered in future systematic reviews.PCD and ADF were supported by the European Union 7th Framework Programme [FP7-PEOPLE-2012-IRSES (FUEGO grant no. 612547), and FP7-PEOPLE-2013-IRSES (U-GENE grant no. 319010)]. PS was supported by the Swedish Federal Government under the LUA/ALF agreement (grant no. ALFGBG-431481)

The effect of selected synbiotics on microbial composition and short-chain Fatty Acid production in a model system of the human colon.

Prebiotics, probiotics and synbiotics can be used to modulate both the composition and activity of the gut microbiota and thereby potentially affecting host health beneficially. The aim of this study was to investigate the effects of eight synbiotic combinations on the composition and activity of human fecal microbiota using a four-stage semicontinuous model system of the human colon.Carbohydrates were selected by their ability to enhance growth of the probiotic bacteria Lactobacillus acidophilus NCFM (NCFM) and Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) under laboratory conditions. The most effective carbohydrates for each probiotic were further investigated, using the colonic model, for the ability to support growth of the probiotic bacteria, influence the composition of the microbiota and stimulate formation of short-chain fatty acids (SCFA).The following combinations were studied: NCFM with isomaltulose, cellobiose, raffinose and an oat β-glucan hydrolysate (OBGH) and Bl-04 with melibiose, xylobiose, raffinose and maltotriose. All carbohydrates showed capable of increasing levels of NCFM and Bl-04 during fermentations in the colonic model by 10(3)-10(4) fold and 10-10(2) fold, respectively. Also the synbiotic combinations decreased the modified ratio of Bacteroidetes/Firmicutes (calculated using qPCR results for Bacteroides-Prevotella-Porphyromonas group, Clostridium perfringens cluster I, Clostridium coccoides - Eubacterium rectale group and Clostridial cluster XIV) as well as significantly increasing SCFA levels, especially acetic and butyric acid, by three to eight fold, as compared to the controls. The decreases in the modified ratio of Bacteroidetes/Firmicutes were found to be correlated to increases in acetic and butyric acid (p=0.04 and p=0.03, respectively).The results of this study show that all synbiotic combinations investigated are able to shift the predominant bacteria and the production of SCFA of fecal microbiota in a model system of the human colon, thereby potentially being able to manipulate the microbiota in a way connected to human health

Improved Success Probability with Greater Circuit Depth for the Quantum Approximate Optimization Algorithm

Present-day, noisy, small or intermediate-scale quantum processors-although far from fault tolerant-support the execution of heuristic quantum algorithms, which might enable a quantum advantage, for example, when applied to combinatorial optimization problems. On small-scale quantum processors, validations of such algorithms serve as important technology demonstrators. We implement the quantum approximate optimization algorithm on our hardware platform, consisting of two superconducting transmon qubits and one parametrically modulated coupler. We solve small instances of the NP (nondeterministic polynomial time)-complete exact-cover problem, with 96.6% success probability, by iterating the algorithm up to level two

Pro-inflammatory S100A9 protein as a robust biomarker differentiating early stages of cognitive impairment in Alzheimer’s Diseased

Pro-inflammatory protein S100A9 was established as a biomarker of dementia progression and compared with others such as Aβ1−42and tau-proteins. CSF samples from 104 stringently diagnosed individuals divided into five subgroups were analyzed, including nondemented controls, stable mild cognitive impairment (SMCI), mild cognitive impairment due to Alzheimer’s disease (MCI-AD), Alzheimer’s disease (AD), and vascular dementia (VaD) patients. ELISA, dot-blotting, and electrochemical impedance spectroscopy were used as research methods. The S100A9 and Aβ1−42 levels correlated with each other: their CSF content decreased already at the SMCI stage and declined further under MCIAD, AD, and VaD conditions. Immunohistochemical analysis also revealed involvement of both Aβ1−42 and S100A9 in the amyloid-neuroinflammatory cascade already during SMCI. Tau proteins were not yet altered in SMCI; however their contents increased during MCI-AD and AD, diagnosing later dementia stages. Thus, four biomarkers together, reflecting different underlying pathological causes, can accurately differentiate dementia progression and also distinguish AD from Va