Modelling alternative strategies for delivering hepatitis B vaccine in prisons : the impact on the vaccination coverage of the injecting drug user population

Since 2001 hepatitis B vaccination has been offered to prisoners on reception into prisons in England and Wales. However, short campaigns of vaccinating the entire population of individual prisons have achieved high vaccination coverage for limited periods, suggesting that short campaigns may be a preferable way of vaccinating prisoners. A model is used that describes the flow of prisoners through prisons stratified by injecting status to compare a range of vaccination scenarios that describe vaccination on prison reception or via regular short campaigns. Model results suggest that vaccinating on prison reception can capture a greater proportion of the injecting drug user (IDU) population than the comparable campaign scenarios (63% vs. 55 . 6% respectively). Vaccination on prison reception is also more efficient at capturing IDUs for vaccination than vaccination via a campaign, although vaccination via campaigns may have a role with some infections for overall control

Modelling the hepatitis B vaccination programme in prisons

A vaccination programme offering hepatitis B (HBV) vaccine at reception into prison has been introduced into selected prisons in England and Wales. Over the coming years it is anticipated this vaccination programme will be extended. A model has been developed to assess the potential impact of the programme on the vaccination coverage of prisoners, ex-prisoners, and injecting drug users (IDUs). Under a range of coverage scenarios, the model predicts the change over time in the vaccination status of new entrants to prison, current prisoners and IDUs in the community. The model predicts that at baseline in 2012 57% of the IDU population will be vaccinated with up to 72% being vaccinated depending on the vaccination scenario implemented. These results are sensitive to the size of the IDU population in England and Wales and the average time served by an IDU during each prison visit. IDUs that do not receive HBV vaccine in the community are at increased risk from HBV infection. The HBV vaccination programme in prisons is an effective way of vaccinating this hard-to-reach population although vaccination coverage on prison reception must be increased to achieve this

Visualising gas heating from an RF plasma loudspeaker

In an electro-acoustic transduction mechanism, an ac modulation (here in the audio frequency range) of the electric field in an atmospheric pressure air plasma gives rise to a rapid increase in the gas temperature and dimensions of the gas volume. As in natural lightning, the rapid expansion in the ionised column though the air produces external pressure variations at the modulation frequency.  \ud Spatial and temporal measurement of the gas temperature can identify the nature of the thermal expansion and provide a direct approach to understanding its relationship to the sound pressure wave that is generated. However, the established method through spectroscopic measurement of rotational line emission from nitrogen molecules is limited to the main current channel where relaxation and subsequent optical emission of the excited nitrogen molecules occurs. The wider picture is revealed through the use of the Schlieren method where the refractive index gradients caused by gas heating in the plasma are imaged

Size-scaling limits of impulsive elastic energy release from a resilin-like elastomer

Elastically-driven motion has been used as a strategy to achieve high speeds in small organisms and engineered micro-robotic devices. We examine the size-scaling relations determining the limit of elastic energy release from elastomer bands with mechanical properties similar to the biological protein resilin. The maximum center-of-mass velocity of the elastomer bands was found to be size-scale independent, while smaller bands demonstrated larger accelerations and shorter durations of elastic energy release. Scaling relationships determined from these measurements are consistent with the performance of small organisms which utilize elastic elements to power motion. Engineered devices found in the literature do not follow the same size-scaling relationships, which suggests an opportunity for improved design of engineered devices.Comment: 9 pages, 4 figure

Why do Large Animals Never Actuate Their Jumps with Latch-Mediated Springs? Because They can Jump Higher Without Them.

As animals get smaller, their ability to generate usable work from muscle contraction is decreased by the muscle's force-velocity properties, thereby reducing their effective jump height. Very small animals use a spring-actuated system, which prevents velocity effects from reducing available energy. Since force-velocity properties reduce the usable work in even larger animals, why don't larger animals use spring-actuated jumping systems as well? We will show that muscle length-tension properties limit spring-actuated systems to generating a maximum one-third of the possible work that a muscle could produce-greatly restricting the jumping height of spring-actuated jumpers. Thus a spring-actuated jumping animal has a jumping height that is one-third of the maximum possible jump height achievable were 100% of the possible muscle work available. Larger animals, which could theoretically use all of the available muscle energy, have a maximum jumping height that asymptotically approaches a value that is about three times higher than that of spring-actuated jumpers. Furthermore, a size related "crossover point" is evident for these two jumping mechanisms: animals smaller than this point can jump higher with a spring-actuated mechanism, while animals larger than this point can jump higher with a muscle-actuated mechanism. We demonstrate how this limit on energy storage is a consequence of the interaction between length-tension properties of muscles and spring stiffness. We indicate where this crossover point occurs based on modeling and then use jumping data from the literature to validate that larger jumping animals generate greater jump heights with muscle-actuated systems than spring-actuated systems

Validity and practical utility of accelerometry for the measurement of in-hand physical activity in horses

Background: Accelerometers are valid, practical and reliable tools for the measurement of habitual physical activity (PA). Quantification of PA in horses is desirable for use in research and clinical settings. The objective of this study was to evaluate a triaxial accelerometer for objective measurement of PA in the horse by assessment of their practical utility and validity. Horses were recruited to establish both the optimal site of accelerometer attachment and questionnaire designed to explore owner acceptance. Validity and cut-off values were obtained by assessing PA at various gaits. Validation study- 20 horses wore the accelerometer while being filmed for 10 min each of rest, walking and trotting and 5 mins of canter work. Practical utility study- five horses wore accelerometers on polls and withers for 18 h; compliance and relative data losses were quantified. Results: Accelerometry output differed significantly between the four PA levels (P <0•001) for both wither and poll placement. For withers placement, ROC analyses found optimal sensitivity and specificity at a cut-off of <47 counts per minute (cpm) for rest (sensitivity 99.5 %, specificity 100 %), 967–2424 cpm for trotting (sensitivity 96.7 %, specificity 100 %) and ≥2425 cpm for cantering (sensitivity 96.0 %, specificity 97.0 %). Attachment at the poll resulted in optimal sensitivity and specificity at a cut-off of <707 counts per minute (cpm) for rest (sensitivity 97.5 %, specificity 99.6 %), 1546–2609 cpm for trotting (sensitivity 90.33 %, specificity 79.25 %) and ≥2610 cpm for cantering (sensitivity 100 %, specificity 100 %) In terms of practical utility, accelerometry was well tolerated and owner acceptance high. Conclusion: Accelerometry data correlated well with varying levels of in-hand equine activity. The use of accelerometers is a valid method for objective measurement of controlled PA in the horse

Mapping Coherent, Time-Varying Wavefronts from the Tohoku Tsunami into Enhanced, Time-Dependent Warning Messages

Recent results are presented to illustrate how predictions of tsunami wave impact and tsunami warning mes-sages can be improved by including information about multiple, large-amplitude wave arrivals over longer time durations and at refined spatial resolution. A deployment of ocean bottom seismometers off the coast of southern California recorded the March 2011 Tohoku tsunami on 22 differential pressure gauges. The pressure gauge tsu-nami records across the entire array show multiple large-amplitude, coherent phases arriving one hour to more than 36 hours after the initial tsunami phase. Analysis of the pressure gauge recordings reveals possible locations of the geographical sources that contributed to secondary tsunami arrivals in southern California. A beamform-ing technique is applied to the pressure gauge data to determine the azimuths and arrival times of scattered wave energy. In addition, a backward ray-tracing procedure is applied to a wide range of back azimuth starting values from the pressure gauge array to map possible scattering source locations. The results show several possible candidates of secondary tsunami source structures. These include: (1) southeastern Alaska producing a tsunami arrival 1–2 hours after the first arrival; and elongated bathymetry structures near: (2) the northern Hawaiian Is-land chain producing an arrival 1–2 hours, (3) Papua New Guinea producing an arrival 8–9 hours, and (4) French Polynesia producing an arrival 10–11 hours, all after the first arrival. These results are then incorporated into tsunami warning messages to improve clarity of the hazard threat and protective action guidance, and the specificity of impact location over time. Revised tsunami messages have been tested through online experiments with the public in order to determine how changes in message clarity and specificity affects message receiver understanding, believing, and personalizing, all of which are pre-decisional sense-making activities. The geo-physical results are mapped into modified tsunami warning messages to show how a time-varying hazard could be communicated with more effective message format and content. The results are demonstrating the effects of including clearly described locations, time of impact, and hazard impact consequences on message perception among the public

Towards a mathematical understanding of learning from few examples with nonlinear feature maps

We consider the problem of data classification where the training set consists of just a few data points. We explore this phenomenon mathematically and reveal key relationships between the geometry of an AI model's feature space, the structure of the underlying data distributions, and the model's generalisation capabilities. The main thrust of our analysis is to reveal the influence on the model's generalisation capabilities of nonlinear feature transformations mapping the original data into high, and possibly infinite, dimensional spaces.Comment: 18 pages, 8 figure