Pain sensitivity, negative affect, and alcohol use disorder status: A moderated mediation study of emotion dysregulation

Previous work suggests that the association between pain and emotional processes among individuals with alcohol use disorder (AUD) may differ from healthy controls. This study inves-tigates whether pain sensitivity mediates the association between negative affect and emotional dysregulation and whether this association differs across AUD status using moderated mediation. The sample included 165 individuals diagnosed with AUD and 110 healthy controls. Of interest was pain sensitivity, as assessed with the Pain Sensitivity Questionnaire, negative affect, as assessed with the Beck Depression Inventory, and emotional dysregulation, as assessed with the Difficulties in Emotional regulation Scale. Age, biological sex, and current pain severity were included as covariates. The results support a moderated partial mediation model that explained 44% of the variance in emotional dysregulation. The findings indicate that negative affect is related to higher pain sensitivity across groups. Moreover, pain sensitivity partially mediated the association between negative affect and emotional dysregulation, but in opposite directions depending on AUD status. Among healthy controls, greater pain sensitivity was related to better emotional regulation, while greater pain sensitivity led to greater emotional dysregulation among individuals with AUD. The potential parallels in the underlying neurobiological mechanisms of emotionality, pain, and AUD suggest that interventions targeting pain may improve adaptive affect regulation skills, which in turn could reduce negative affect and its effect on pain sensitivity among individuals with AUD

Geometrical Aberration Suppression for Large Aperture Sub-THz Lenses

Advanced THz setups require high performance optical elements with large numerical apertures and small focal lengths. This is due to the high absorption of humid air and relatively low efficiency of commercially available detectors. Here, we propose a new type of double-sided sub-THz diffractive optical element with suppressed geometrical aberration for narrowband applications (0.3 THz). One side of the element is designed as thin structure in non-paraxial approach which is the exact method, but only for ideally flat elements. The second side will compensate phase distribution differences between ideal thin structure and real volume one. The computer-aided optimization algorithm is performed to design an additional phase distribution of correcting layer assuming volume designing of the first side of the element. The experimental evaluation of the proposed diffractive component created by 3D printing technique shows almost two times larger performance in comparison with uncorrected basic diffractive lens

Comportamento hidráulico de gotejadores em linha lateral de irrigação

O desenvolvimento e a incorporação de novos produtos na área da irrigação é cada dia mais rápido, devido principalmente ao processo de globalização. Essa incorporação é feita, no entanto, na maioria das vezes, de forma indiscriminada, principalmente no Brasil, em que não existe nenhum órgão fiscalizador da qualidade do produto. Assim, os objetivos do presente trabalho foram caracterizar hidraulicamente o gotejador modelo HPC e verificar a sua uniformidade de aplicação de água em uma linha lateral. Nessa análise trabalhou-se com uma amostra de 20 gotejadores obtidos aleatoriamente de um lote de 50 gotejadores. A uniformidade de distribuição foi avaliada a partir dos dados de vazão coletados em uma linha lateral de 20 m, com um diâmetro nominal de 20 mm. Na referida linha, 20 gotejadores foram instalados de modo eqüidistante, espaçados entre si de 0,5 m, operando em uma faixa de pressão de 50 a 500 kPa. Os resultados mostraram que os valores de 50 kPa e 500 kPa não apresentaram resultados satisfatórios com índices de 80% a 90% de uniformidade de vazão. Já as análises com a pressão variando entre 100 e 350 kPa mostraram um alto índice de uniformidade, na média 96%

Uso das distribuições gama e log-normal na estimativa de precipitação provável quinzenal

O objetivo deste trabalho foi avaliar o uso das distribuições Gama e Log-normal na estimativa de precipitações pluviais prováveis quinzenais no Estado do Paraná, utilizando como testes de aderência as distribuições de Qui-quadrado e Kolmogorov-Smirnov, ambos com 5% de significância. Utilizaram-se dados diários de precipitação de 22 estações de medição. Os resultados mostraram que a distribuição Gama se ajustou mais adequadamente às condições pluviométricas do Estado. Os meses mais chuvosos são janeiro e fevereiro, enquanto os mais secos são julho e agosto. O estado do Paraná apresenta aumento na quantidade de precipitação pluviométrica na direção litoral/oeste e norte/sul

Interoception, alexithymia, and anxiety among individuals with alcohol use disorder

BackgroundInteroception (i.e., the ability to recognize bodily signals), alexithymia (i.e., the inability to recognize emotional states) and negative affect (i.e., unpleasant feelings such as anxiety) have been associated with alcohol use disorder (AUD). Previous research suggests that interoception may underlie alexithymia, which in turn may be associated with negative affectivity. However, this remains to be empirically tested. This study investigates whether alexithymia mediates the association between interoception and anxiety and whether this association differs across individuals with AUD and a healthy control (HC) comparison group.MethodsThe AUD group consisted of 99 participants enrolled in an 8-week abstinence-based inpatient treatment program. The HC group included 103 healthy individuals. The heartbeat counting task (HCT) was used to assess interoception (cardiac interoceptive accuracy). The Toronto Alexithymia Scale (TAS-20) was used to assess alexithymia. The Brief Symptom Inventory (BSI) was used to assess anxiety.ResultsThe moderated mediation model with interoception as the predictor, alexithymia as the mediator, and negative affect (i.e., state anxiety) as the dependent variable was tested. The analysis showed that the conditional indirect effect of interoception on anxiety via alexithymia was significant for individuals with AUD [ab = −0.300, bootstrap 95% CI = (−0.618, −0.088)], as well as for HCs [ab = −0.088, bootstrap 95% CI = (−0.195, −0.014)]; however, the conditional indirect effect significantly differed across HCs and individuals with AUD. Namely, the mediated effect was greater among individuals with AUD compared to the HC group.ConclusionThe results suggests that interoceptive impairment contributes to greater negative affect (i.e., state anxiety) via alexithymia especially for individuals with AUD. Improving emotion recognition via therapeutic methods focused on strengthening interoceptive abilities could improve outcomes for individuals receiving treatment for AUD

On the monoidal structure of matrix bi-factorisations

We investigate tensor products of matrix factorisations. This is most naturally done by formulating matrix factorisations in terms of bimodules instead of modules. If the underlying ring is C[x_1,...,x_N] we show that bimodule matrix factorisations form a monoidal category. This monoidal category has a physical interpretation in terms of defect lines in a two-dimensional Landau-Ginzburg model. There is a dual description via conformal field theory, which in the special case of W=x^d is an N=2 minimal model, and which also gives rise to a monoidal category describing defect lines. We carry out a comparison of these two categories in certain subsectors by explicitly computing 6j-symbols.Comment: 43 pages; v2: corrected a mistake in sec. 1 and app. A.1, the results are unaffected; v3: minor change

Replication and Recombination Factors Contributing to Recombination-Dependent Bypass of DNA Lesions by Template Switch

Damage tolerance mechanisms mediating damage-bypass and gap-filling are crucial for genome integrity. A major damage tolerance pathway involves recombination and is referred to as template switch. Template switch intermediates were visualized by 2D gel electrophoresis in the proximity of replication forks as X-shaped structures involving sister chromatid junctions. The homologous recombination factor Rad51 is required for the formation/stabilization of these intermediates, but its mode of action remains to be investigated. By using a combination of genetic and physical approaches, we show that the homologous recombination factors Rad55 and Rad57, but not Rad59, are required for the formation of template switch intermediates. The replication-proficient but recombination-defective rfa1-t11 mutant is normal in triggering a checkpoint response following DNA damage but is impaired in X-structure formation. The Exo1 nuclease also has stimulatory roles in this process. The checkpoint kinase, Rad53, is required for X-molecule formation and phosphorylates Rad55 robustly in response to DNA damage. Although Rad55 phosphorylation is thought to activate recombinational repair under conditions of genotoxic stress, we find that Rad55 phosphomutants do not affect the efficiency of X-molecule formation. We also examined the DNA polymerase implicated in the DNA synthesis step of template switch. Deficiencies in translesion synthesis polymerases do not affect X-molecule formation, whereas DNA polymerase δ, required also for bulk DNA synthesis, plays an important role. Our data indicate that a subset of homologous recombination factors, together with DNA polymerase δ, promote the formation of template switch intermediates that are then preferentially dissolved by the action of the Sgs1 helicase in association with the Top3 topoisomerase rather than resolved by Holliday Junction nucleases. Our results allow us to propose the choreography through which different players contribute to template switch in response to DNA damage and to distinguish this process from other recombination-mediated processes promoting DNA repair