Factors influencing and changes in childhood vaccination coverage over time in Bangladesh: a multilevel mixed-effects analysis

Introduction: This study aimed to investigate the associated factors and changes in childhood vaccination coverage over time in Bangladesh. Methods: Bangladesh’s Demographic and Health Surveys from 2011, 2014, and 2017-18 provided data for this study on vaccination coverage among children aged 12 to 35 months. For three survey periods, multilevel binary logistic regression models were employed. Results: The overall prevalence (weighted) of full vaccination among children aged 12–35 months were 86.17% in 2011, 85.13% in 2014, and 89.23% in 2017-18. Children from families with high wealth index, mothers with higher education, and over the age of 24 and who sought at least four ANC visits, as well as children from urban areas were more likely to receive full vaccination. Rangpur division had the highest change rate of vaccination coverage from 2011 to 2014 (2.26%), whereas Sylhet division had the highest change rate from 2014 to 2017-18 (34.34%). Conclusion: To improve immunization coverage for Bangladeshi children, policymakers must integrate vaccine programs, paying special attention to mothers without at least a high school education and families with low wealth index. Increased antenatal care visits may also aid in increasing the immunization coverage of their children

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Mapping of Agriculture Research in Bangladesh: A Scientometric Analysis

This study counts the number of the agricultural research conducted ingeographic area of Bangladeshduring the year 1976 to 2018, indexed in BanglaJOL. It attempts to examine the research performance of all agriculture research publications by Bangladeshi scientists. The BanglaJOL was used to collect the data to find the publication produced in the geographic area of Bangladesh. Different types of journals were examined and 4119 agriculture research papers were found. The research result was made on several parameters: publication outputs, subject categories and major journals, author productivity, geographic and institutional distribution of publications, and keyword-density analysis. From the result, the publications get relative growth rate, ranking of agriculture research journals, doubling time, leading institution, most prolific Bangladeshi institutions such as author productivity, authorship collaboration, degree of collaboration, collaboration index and collaborative coefficient, major collaborating partner countries and keyword density analysis for highly researched keywords.

Impact of E-resources in Promoting Reading Habits: A Study among the Central Library Users of University of Rajshahi, Bangladesh

The widespread adoption of electronic resources, particularly in the realm of reading books, has transformed the landscape of academic libraries across the globe. This study explores the impact of e-resources on the reading habits and preferences of Central Library users at the University of Rajshahi. By analyzing the attitudes and experiences of students, faculty, and researchers, this research sheds light on the significance of e-resources in modern-day learning environments. The core purposes of the study are to investigate the trend and impact of using electronic resources, to explore the reasons, to know the benefits of using e-resources by the students. Out of 200 students only 85% students are familiar with e-resources. Only 90% of students use e-resources. They use e-resources for learning, reading, teaching, jobs, recreation, news etc. They use different types of e-resources such as e-books, e-journals, e-magazine, e-maps, e-news etc. They prefer mobile phones most to access e-resources. But due to a lack of adequate collection, high speed internet connection, proper knowledge, and infrastructure, they face many difficulties in using e-resources in the central library

Food security status and its determinants: A comparative study between farm households under government and non-government agricultural extension services in Bangladesh

The ability to obtain food security is essential to human existence. Secure food access can have a variety of positive effects, such as economic expansion, the creation of jobs, and the eradication of poverty. This study assessed the food security status of farm households and its determinants in the Dinajpur district of Bangladesh. Efforts were also made to assess and compare the socio-economic demographics and item-wise calorie intake among households receiving government and non-government agricultural extension services. One hundred twenty-five (125) farm households receiving government or non-government extension services were selected using a multi-stage random sampling procedure. The percentages, means, and standard deviations were employed to summarise the data gathered during the interviews. The inferential statistical investigation involved using the independent sample t-test, correlation analysis, and multiple regression analysis. The findings revealed that 68.8 percent of the families in the study area were food secure, while food insecurity was more prevalent for those receiving non-government extension services. In addition, significant differences existed between the selected characteristics of the two groups of farmers in terms of age, household head’s education, average family education, household size, farm size, farming experience, annual household income, annual household expenditure, knowledge on food and nutrition, and extension sources contact. There were also large discrepancies between the food item-wise calorie consumption between the two groups of farmers. The major determinants of household food security were dependency ratio, household size, training exposure, annual household income, knowledge on food and nutrition, and extension sources contact. It is recommended that both government and non-government agricultural extension organisations work together in an effective, transparent, and unbiased manner to reduce food insecurity

Growth and characterization of ??-Ga2O3 thin films by molecular beam epitaxy for deep-UV photodetectors

The growth of high quality epitaxial beta-gallium oxide (??-Ga2O3) using a compound source by molecular beam epitaxy has been demonstrated on c-plane sapphire (Al2O3) substrates. The compound source provides oxidized gallium molecules in addition to oxygen when heated from an iridium crucible in a high temperature effusion cell enabling a lower heat of formation for the growth of Ga2O3, resulting in a more efficient growth process. This source also enabled the growth of crystalline ??-Ga2O3 without the need for additional oxygen. The influence of the substrate temperatures on the crystal structure and quality, chemical bonding, surface morphology, and optical properties has been systematically evaluated by x-ray diffraction, scanning transmission electron microscopy, x-ray photoelectron spectroscopy, atomic force microscopy, spectroscopic ellipsometry, and UV-vis spectroscopy. Under optimized growth conditions, all films exhibited pure 201 oriented ??-Ga2O3 thin films with six-fold rotational symmetry when grown on a sapphire substrate. The thin films demonstrated significant absorption in the deep-ultraviolet (UV) region with an optical bandgap around 5.0 eV and a refractive index of 1.9. A deep-UV photodetector fabricated on the high quality ??-Ga2O3 thin film exhibits high resistance and small dark current (4.25 nA) with expected photoresponse for 254 nm UV light irradiation suggesting that the material grown using the compound source is a potential candidate for deep-ultraviolet photodetectors

Development of Glyceryl Monostearate Based Ciprofloxacin Hydrochloride Sustained Release Matrix Tablet: an In vitro Study

ABSTRACT: In this present study an attempt has been made to evaluate glyceryl monostearate (GMS) as a rate retarding material to sustain the release ciprofloxacin hydrochloride from the matrix tablet. The solubility of ciprofloxacin hydrochloride was studied. The physical parameters of the prepared tablets were also evaluated. Release kinetics of ciprofloxacin hydrochloride from this sustained release matrix was studied in 0.1 N HCl using United States Pharmacopoeia type-II dissolution apparatus (paddle method). The effect of polymer load, drug load, hydroxylpropylmethylcellulose to compensate glyceryl monostearate (GMS) and different release modifiers were examined. It was observed that the release rate of drug was retarded with the increasing concentration of GMS. The release data were treated in different fashion to identify the release mechanism and it was revealed with few exception that, when GMS is used as single polymer, release of active drug from the prepared matrix tablet appeared to follow the first order kinetics and showed the tendency to follow Korsmeyer model when HPMC 15 cps was used along with GMS. Using release enhancers the release pattern were fitted to first order kinetics. From the f2 values i

First detection and characterization of mcr-1 colistin resistant E. coli from wild rat in Bangladesh.

Colistin resistance is a global concern warning for a one health approach to combat the challenge. Colistin resistant E. coli and their resistance determinants are widely distributed in the environment, and rats could be a potential source of these isolates and resistant determinants to a diverse environmental setting. This study was aimed to determine the presence of colistin resistant E. coli (CREC) in wild rats, their antimicrobial resistance (AMR) phenotypes, and genotypic analysis of mcr-1 CREC through whole genome sequencing (WGS). A total of 39 rats were examined and CREC was isolated from their fecal pellets onto MacConkey agar containing colistin sulfate (1 μg/ mL). AMR of the CREC was determined by disc diffusion and broth microdilution was employed to determine MIC to colistin sulfate. CREC were screened for mcr genes (mcr-1 to mcr-8) and phylogenetic grouping by PCR. Finally, WGS of one mcr-1 CREC was performed to explore its genetic characteristics especially resistomes and virulence determinants. 43.59% of the rats carried CREC with one (2.56%) of them carrying CREC with mcr-1 gene among the mcr genes examined. Examination of seventeen (17) isolates from the CREC positive rats (n = 17) revealed that majority of them belonging to the pathogenic phylogroup D (52.94%) and B2 (11.76%). 58.82% of the CREC were MDR on disc diffusion test. Shockingly, the mcr-1 CREC showed phenotypic resistance to 16 antimicrobials of 8 different classes and carried the ARGs in its genome. The mcr-1 gene was located on a 60 kb IncI2 plasmid. On the other hand, ARGs related to aminoglycosides, phenicols, sulfonamides, tetracyclines and trimethoprims were located on a 288 kb mega-plasmid separately. The mcr-1 CREC carried 58 virulence genes including genes related to adhesion, colonization, biofilm formation, hemolysis and immune-evasion. The isolate belonged to ST224 and closely related to E. coli from different sources including UPEC clinical isolates from human based on cgMLST analysis. The current research indicates that rats might be a possible source of CREC, and the presence of mcr-1 and other ARGs on plasmid increases the risk of ARGs spreading and endangering human health and other environmental components through this infamous pest

Antiviral activities of ginseng and its potential and putative benefits against monkeypox virus: A mini review

Due to the Covid-19 pandemic more than 6 million people have died, and it has bought unprecedented challenges to our lives. The recent outbreak of monkeypox virus (MPXV) has brought out new tensions among the scientific community. Currently, there is no specific treatment protocol for MPXV. Several antivirals, vaccinia immune globulin (VIG) and smallpox vaccines have been used to treat MPXV. Ginseng, one of the more famous among traditional medicines, has been used for infectious disease for thousands of years. It has shown promising antiviral effects. Ginseng could be used as a potential adaptogenic agent to help prevent infection by MPXV along with other drugs and vaccines. In this mini review, we explore the possible use of ginseng in MPXV prevention based on its antiviral activity

A Comprehensive Study on Next-Generation Electromagnetics Devices and Techniques for Internet of Everything (IoE)

Evolution of mobile broadband is ensured by adopting a unified and more capable radio interface (RI). For ubiquitous connectivity among a wide variety of wireless applications, the RI enables the adoption of an adaptive bandwidth with high spectrum flexibility. To this end, the modern-day communication system needs to cater to extremely high bandwidth, starting from below 1 GHz to 100 GHz, based on different deployments. This instigates the creation of a platform called the Internet of Everything (IoE), which is based on the concept of all-round connectivity involving humans to different objects or things via sensors. In simple words, IoE is the intelligent connection of people, processes, data, and things. To enable seamless connectivity, IoE resorts to low-cost, compact, and flexible broadband antennas, RFID-based sensors, wearable electromagnetic (EM) structures, circuits, wireless body area networks (WBAN), and the integration of these complex elements and systems. IoE needs to ensure broader information dissemination via simultaneous transmission of data to multiple users through separate beams and to that end, it takes advantage of metamaterials. The precise geometry and arrangement of metamaterials enable smart properties capable of manipulating EM waves and essentially enable the metamaterial devices to be controlled independently to achieve desirable EM characteristics, such as the direction of propagation and reflection. This review paper presents a comprehensive study on next-generation EM devices and techniques, such as antennas and circuits for wearable and sub 6 GHz 5G applications, WBAN, wireless power transfer (WPT), the direction of arrival (DoA) of propagating waves, RFID based sensors for biomedical and healthcare applications, new techniques of metamaterials as well as transformation optics (TO) and its applications in designing complex media and arbitrary geometry conformal antennas and optical devices that will enable future IoE applications