446 research outputs found

    Women post-recession: moving towards insecurity

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    After the recession, the rise in casual and precarious contracts is entrenching gender inequality in the UK

    Public Sector Employment in Scotland Statistics For 4th Quarter 2013

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    Does cancer type influence the impact of recurrence? : a review of the experience of patients with breast or prostate cancer recurrence

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    Objective: Patients will experience a plethora of issues when faced with a recurrence of their cancer. It is unclear if cancer type is a significant factor in how recurrence is experienced by an individual. The aim of the current review is to explore the evidence base and summarise the experiences of patients specifically with a recurrence of breast or prostate cancer (the most common for women and men, respectively) and then provide a comparison of these experiences. These experiences include the physical, psychological and psychosocial issues that arise at this time.  Methods: A systematic search was conducted of studies published between January 1994 and April 2019. Due to the mix of research designs used previously in the literature, this review was conducted in an integrative manner; allowing for inclusion of diverse research designs. Results were synthesised narratively, with data categorised according to physical, psychological, and psychosocial indices of quality of life. The review protocol was registered in the international database of prospective systematic reviews in health and social care- (CRD42019137381).  Results: Fifteen breast cancer and six prostate cancer articles were identified, each reporting one relevant study. Patients reported several negative issues at the time of a breast or prostate cancer recurrence. Similarities were found between cancer types, with physical problems such as fatigue, psychological issues including anxiety and depressive symptoms, and psychosocial concerns such as issues with healthcare professionals common in both cancers. Certain findings were inconsistent across studies, with some experiences differing between studies rather than due to cancer type.  Conclusions: Differences in the experience of recurrent cancer appear to be more heavily influenced by individual factors, rather than cancer type. Findings are confounded by gender; and should be considered preliminary. Effects of recurrence should be studied in samples where cancer type and gender are not confounded. Concerns are raised about available study quality and differing outcome measures in this interpretation. Care and support of the individual at the time of a cancer recurrence is a key focus. Future research suggestions with implications for clinical practise are included.Publisher PDFPeer reviewe

    Tailored Forming of hybrid bulk metal components

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    Multi-material bulk metal components allow for a resource efficient and functionally structured component design, with a load adaptation achieved in certain functional areas by using similar and dissimilar material combinations. One possibility for the production of hybrid bulk metal components is Tailored Forming, in which pre-joined semi-finished products are hot-formed using novel process chains. By means of Tailored Forming, the properties of the joining zone are geometrically and thermomechanically influenced during the forming process. Based on this motivation, forming processes (die forging, impact extrusion) coupled with adapted inductive heating strategies were designed using numerical simulations and successfully realised in the following work in order to produce demonstrator components with serial or coaxial material arrangements. The quality of the joining zone was investigated through metallographic and SEM imaging, tensile tests and life cycle tests. By selecting suitable materials, it was possible to achieve weight savings of 22% for a pinion shaft and up to 40% for a bearing bush in the material combination of steel and aluminium with sufficient strength for the respective application. It was shown that the intermetallic phases formed after friction welding barely grow during the forming process. By adjusting the heat treatment of the aluminium, the growth of the IMP can also be reduced in this process step. Furthermore, for steel-steel components alloy savings of up to 51% with regard to chromium could be achieved when using low-alloy steel as a substitute for high-alloy steel parts in less loaded sections. The welded microstructure of a cladded bearing washer could be transformed into a homogeneous fine-grained microstructure by forming. The lifetime of tailored formed washers nearly reached those of high-alloyed mono-material components

    Development and content validation of a questionnaire measuring patient empowerment in cancer follow-up

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    Purpose: The aim of this study was to develop and ensure the content validity of a new patient-reported outcome measure, the Cancer Patient Empowerment Questionnaire (CPEQ), to measure the level of, desire for, and enablement of empowerment among cancer patients in follow-up. Methods: An iterative process based on: (i) empowerment theories by Zimmerman and Tengland, (ii) a systematic review of questionnaires measuring empowerment or related concepts among cancer patients, (iii) qualitative data from 18 semi-structured interviews with Danish cancer patients in follow-up, (iv) input from a group of eight cancer patients involved as co-researchers and from an expert steering group, and (v) cognitive interviews with 15 cancer patients in follow-up. Results: The items for the CPEQ were developed and revised and 12 versions of the questionnaire were evaluated. The final version consists of 67 items, covering three different dimensions of empowerment: (A) empowerment outcomes consisting of three components: (A1) the intrapersonal-, (A2) interactional-, and (A3) behavioral component, (B) empowerment facilitators (enablement), and (C) the value of empowerment. Conclusions: This study documents the theoretical and empirical basis for the development of the CPEQ and its content validity. The CPEQ provides a tool for researchers to assess the level of, desire for, and enablement of empowerment among cancer patients. The next steps will be to use the CPEQ in a nationwide study of empowerment in cancer follow-up and subsequently shorten the CPEQ based on psychometric methods in order to make it more relevant in clinical studies

    Properties and biases of the global heat flow compilation

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    Geothermal heat flow is inferred from the gradient of temperature values in boreholes or short-penetration probe measurements. Such measurements are expensive and logistically challenging in remote locations and, therefore, often targeted to regions of economic interest. As a result, measurements are not distributed evenly. Some tectonic, geologic and even topographic settings are overrepresented in global heat flow compilations; other settings are underrepresented or completely missing. These limitations in representation have implications for empirical heat flow models that use catalogue data to assign heat flow by the similarity of observables. In this contribution, we analyse the sampling bias in the Global Heat Flow database of the International Heat Flow Commission; the most recent and extensive heat flow catalogue, and discuss the implications for accurate prediction and global appraisals. We also suggest correction weights to reduce the bias when the catalogue is used for empirical modelling. From comparison with auxiliary variables, we find that each of the following settings is highly overrepresented for heat flow measurements; continental crust, sedimentary rocks, volcanic rocks, and Phanerozoic regions with hydrocarbon exploration. Oceanic crust, cratons, and metamorphic rocks are underrepresented. The findings also suggest a general tendency to measure heat flow in areas where the values are elevated; however, this conclusion depends on which auxiliary variable is under consideration to determine the settings. We anticipate that using our correction weights to balance disproportional representation will improve empirical heat flow models for remote regions and assist in the ongoing assessment of the Global Heat Flow database

    Digital three-dimensional imaging techniques provide new analytical pathways for malacological research

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    Author Posting. © BioOne Complete, 2019. This article is posted here by permission of BioOne Complete for personal use, not for redistribution. The definitive version was published in Ziegler, A., Bock, C., Ketten, D. R., Mair, R. W., Mueller, S., Nagelmann, N., Pracht, E. D., & Schroeder, L. Digital three-dimensional imaging techniques provide new analytical pathways for malacological research. American Malacological Bulletin, 36(2), (2018):248-273, doi:10.4003/006.036.0205.Research on molluscan specimens is increasingly being carried out using high-throughput molecular techniques. Due to their efficiency, these technologies have effectively resulted in a strong bias towards genotypic analyses. Therefore, the future large-scale correlation of such data with the phenotype will require a significant increase in the output of morphological studies. Three-dimensional (3D) scanning techniques such as magnetic resonance imaging (MRI) or computed tomography (CT) can achieve this goal as they permit rapidly obtaining digital data non-destructively or even entirely non-invasively from living, fixed, and fossil samples. With a large number of species and a relatively complex morphology, the Mollusca would profit from a more widespread application of digital 3D imaging techniques. In order to provide an overview of the capacity of various MRI and CT techniques to visualize internal and external structures of molluscs, more than twenty specimens ranging in size from a few millimeters to well over one meter were scanned in vivo as well as ex vivo. The results show that all major molluscan organ systems can be successfully visualized using both MRI and CT. The choice of a suitable imaging technique depends primarily on the specimen's life condition, its size, the required resolution, and possible invasiveness of the approach. Apart from visual examples derived from more than two dozen scans, the present article provides guidelines and best practices for digital 3D imaging of a broad range of molluscan taxa. Furthermore, a comprehensive overview of studies that previously have employed MRI or CT techniques in malacological research is given.We would like to express our gratitude to Adam J. Baldinger, Thomas Bartolomaeus, Patrick Beckers, Rüdiger Bieler, Roger T. Hanlon, Carsten Lüter, Iliana Ruiz-Cooley, Tom Schiøtte, Andreas Schmidt-Rhaesa, and Sid Staubach for help with specimen collection or for providing access to museum material. Cornelius Faber, Julia Koch, Tony Stöcker, and W. Caroline West kindly facilitated use of scanning systems. We would also like to thank Julie Arruda, Scott Cramer, Jörg Döpfert, Charlotte Eymann, Bastian Maus, Malte Ogurreck, Christina L. Sagorny, Gillian Trombke, and Christopher Witte for support with data acquisition and analysis. We are particularly grateful to Elizabeth K. Shea for inviting the present contribution and for her extensive commentary on the manuscript. We also thank two anonymous reviewers for their helpful criticisms. Funding for this study was provided by the Ocean Life Institute, the Office of Naval Research, the Seaver Institute, and the Deutsche Forschungsgemeinschaft (INST 217/849-1 FUGG)
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