Structure-biological Activity Relationship of Analogues of 2-Chlorobenzylidenemalononitrile -A Riot-control Agent

The riot-control agent 2-chlorobenzylidenemalononitrile (CS) and its ortho-and parasubstituted benzylidenemalononitrile (BMN) analogues were synthesised and characterised by spectroscopic techniques (IR, NMR, and mass spectrometry) and microanalysis, and their structure-biological activity relationship studies were carried out to know the factors responsible for sensory irritation. Hydrophobicity of substituted BMNs were determined by high-performance liquid chromatography (HPLC), which is an important determinant of the irritancy. The vapour pressure of a compound is a physico-chemical property important for the assessment of its fate in the environment. The vapour pressures of BMNs were determined by static method by an isoteniscope. A systematic investigation of sensory irritation was carried out by evaluating decrease in respiratory rate (RDs,) in mice. The R.Dsi as biological parameter was correlated with physical parameters such as hydrophobicity, vapour pressure, size of molecules, and chemical reactivity of its BMNs with dimethylaminoethyl mercaptans (DEAEMs) as a simulant of protein-SH group. A biosignifkant correlation (0.75-0.80) was obtained.by correlating all the above parameters using multiple linear regression equation

Evaluation of Chemical Protective Clothing: A Comparative Study of Breakthrough Times with Sulphur Mustard and a Simulant, 1,3-Dichloropropane

Carbon-coated non-woven fabrics were evaluated against vesicant sulphur mustard and l,3-dichloropropane (DCP). Breakthrough times of these chemicals were compared andfitted in a linear equation. A correlation, better than 95 per cent was obtained. It is recommended that DCP be used in the valuation and quality control of fabric in the chemical protective clothing manufacturing industries to reduce the exposure and risks of handling lethal chemicals. However,-the clothing may be challenged with actual CW agents to determine their protective potentials, in the laboratory. Diffusion coefficients for DCP were also computed from the breakthrough data for carbon-coated fabric of different grades