Dissipative DNA fibres

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DNA-templated assemblies of pi-conjugated molecules

DNA is a central molecule of Life, possessing a formidable information density. Inspired by biomolecular processes such as gene replication and transcription, researchers have utilized DNA as a template to construct, for example, sequence-controlled polymers, photonic wires, and delivery systems.[1-3] In this context, we will report our recent results on the supramolecular assemblies combining nucleic acids and -conjugated molecules (small molecules or polymers), with insights into the templating effect, chirality, self-assembly, and cooperativity.[4,5] We discuss examples of DNA-templated assemblies of photoactive molecules, which can be utilized to modulate the helical assembly of multiple chromophores along DNA fibers.[3,6] Besides, we show that the supramolecular self-assembly of DNA and -conjugated polymers is of interest to probe an enzymatic activity in a label-free, real time fashion.[7,8] Prospective applications of such templated supramolecular assemblies are discussed in the context of biosensing and siRNA delivery. [1] J. Niu, R. Hili, D. R. Liu, Nat. Chem. 2013, 5, 282. [2] N.C. Seeman, H.F. Sleiman, Nat. Rev. Mater. 2017, 3, 17068. [3] M. Surin, S. Ulrich, Chem. Open 2020, 9, 480. [4] J. Rubio-Magnieto, M. Kumar, P. Brocorens, J. Idé, S.J. George, R. Lazzaroni, M. Surin, Chem. Commun. 2016, 52, 13873. [5] N. Holmgaard List, J. Knoops, J. Rubio-Magnieto, J. Idé, D. Beljonne, P. Norman, M. Surin, M. Linares, J. Am. Chem. Soc. 2017, 139, 14947. [6] J. Rubio-Magnieto, T.-A. Phan, M. Fossépré, V. Matot, J. Knoops, T. Jarrosson, P. Dumy, F. Serein-Spirau, C. Niebel, S. Ulrich, M. Surin, Chem. Eur. J. 2018, 24, 706. [7] M. Fossépré, M. Trévisan, V. Cyriaque, R. Wattiez, D. Beljonne, S. Richeter, S. Clément, M. Surin, ACS Appl. Bio Mater. 2019, 2, 2125. [8] M. Fossépré, I. Tuvi-Arad, D. Beljonne, S. Richeter, S. Clément, M. Surin, ChemPhysChem 2020, 21, 2543

Multicomponent Monolayer Architectures at the Solid-Liquid Interface: Towards Controlled Space-Confined Properties and Reactivity of Functional Building Blocks

peer reviewedMulticomponent organic monolayers: Full nanometer-scale organization and positioning of molecules into monolayers at surfaces represents a major challenge for nanotechnology. In this context, recent scanning tunneling microscopy studies were carried out on multicomponent monolayers (for example, involving donor and acceptor molecules) or template monolayers for controlling the adsorption position of functional molecules (see STM image)

Teaching Photosensitizers a New Trick: Red Light-Triggered G-Quadruplex Alkylation by Ligand Co-localization

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