N,N′-Carbonyldiimidazole-MediatedDBU-Catalyzed One-Pot Synthesis of Urea-Tethered Glycosyl AminoAcids and Glycoconjugates

An efficient, mild, simple, and alternative one-pot proto- col for the synthesis of urea-tethered glycosyl amino acids mediated by N,N¢-carbonyldiimidazole employing DBU as a catalyst is de-scribed. This protocol is also extended for the synthesis of urea-teth-ered disaccharides and oligosaccharides

K. M. Sivanandaiah (1931-2011)

K. M. Sivanandaiah, an eminent teacher and an internationally renowned peptide chemist, from the Department of Chemistry, Central College, Bangalore, passed away on 2 October 2011 in Bangalore

Design and development of robust hands for humanoid robots

Design and development of robust hands for humanoid robot

Synthesis of Ureido-Linked Glycosylated Amino Acids from N α-Fmoc-Asp/Glu-5-oxazolidinones and Their Application to Neoglycopeptide Synthesis

A simple route for the synthesis of ureido-linked glycosylated amino acids has been described. The key step involves the reaction of isocyanates derived from N α-Fmoc-Asp/Glu-5-oxazolidinones 1 with glycosyl amines followed by hydrolysis. The resulting ureido-linked glycosylated amino acids have been incorporated into peptides. The overall procedure is simple, high-yielding, and involves fewer steps

Synthesis of peptides employing Fmoc-amino acid chlorides and commercial zinc dust

Coupling of Fmoc-amino acid chlorides mediated by activated commercial zinc dust for the synthesis of peptides is described. The reaction is carried out in an organic medium. The necessity of using an inorganic base like NaHCO3/Na2CO3 or an organic base like DIEA/NMM/TEA/pyridine is circumvented. The coupling is reasonably fast, clean, racemization free and high yielding

Direct synthesis of Fmoc protected amino acid hydroxamates from acid chlorides mediated by magnesium oxide

The synthesis of Fmoc protected amino acid hydroxamates using Fmoc-amino acid chlorides and magnesium oxide is described. The method is simple and efficient, results in complete conversion, and gives good yields and satisfactory purity. © 2003 Elsevier Science Ltd. All rights reserved

ChemInform Abstract: Efficient Synthesis of N‐Fmoc‐Aminoalkoxy Pentafluorophenyl Carbonates: Application for the Synthesis of Oligopeptidyl Carbamates

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