Molecular signatures of in vitro drug response in lung cancer

Poster Presentations - Molecular Classification of Tumors and Novel Biomarkers: abstract no. 5589This journal suppl. entitled : Proceedings: AACR 104th Annual Meeting 2013 ...We are developing in vitro drug response signatures based on profiling of mRNA (Illumina WG6-V3 arrays), DNA mutation (COSMIC and deep sequencing), DNA copy number (Illumina Human1M-Duov3 SNP array) and DNA methylation (Illumina HumanMethylation450) from lung cancer cell lines to predict which drugs a patient's tumor is most likely to respond to. We have generated drug response phenotypes (MTS colorimetric assays) for 25 standard, targeted, and new chemotherapy agents and combinations for 100 ...postprin