Poster- A Visual Stimulus for Active Learning

This paper explores the effect of using poster making inlanguage class, relatively a new concept in the field of languageteaching and learning in the context of Bangladesh. This studywas conducted in tertiary level and the participants had almostsame level of proficiency – intermediate level attending onelanguage course – foundation course in English. In this particularcourse, students got exposure to different activities, and postermaking is one of them. Since language teaching and learning is adynamic field, it requires constant innovation and research onthe contemporary practices in the class and this has made thispaper more of learning from experiences. The specific postermaking activity is in fact a tool for alternative assessment for thestudents in the speaking class thus makes it an action research.To conduct this research one questionnaire was given to thestudents after they presented their poster and later on a set ofquestions was given to the teachers to get the feedback on thatparticular task. Thus both quantitative and qualitative researchmethod was used to get more in-depth comprehensive result.Students could visualize and understand their own progress interms of language use and creativity. The paper aims to see howposter making task transforms a student’s performance over aweek and makes them confident ESL speakers as it works as acatalyst to invigorate the language learning process

Molecular docking and dynamics simulation study of medicinal fungi derived secondary metabolites as potential inhibitor for COVID-19 treatment

The severity of COVID-19, lack of specific treatment, and controversies on the vaccine's efficacy demand the development of new drugs against SARS-CoV-2. Fungi produce various metabolites with diverse molecular structures that have emerged as promising antiviral drug candidates. Therefore, the present study aimed to investigate medicinal fungi derived secondary metabolites as potential inhibitors of 3 different targets associated with viral entry (human TMPRSS2) and replication (main and papain-like protease) through molecular docking and dynamic simulation studies. Based on our findings, we identified Phelligridin E, Lepiotaprocerine G, and Inoscavin A as the potential blockers of SARS-CoV-2 main protease, papain-like protease, and human TMPRSS2, respectively. These compounds strongly interacted with their corresponding target, passed Lipinski Rule's and had acceptable ADMET properties. Drug-protein complexes showed good stability during MD simulation. Estimation of binding free energy using the MM-GBSA method validated the inhibitor potential of identified compounds. Taken together, we believe that further in vitro and in vivo investigations on our proposed molecules may contribute to expanding the therapeutic arsenal in our fight against COVID-19