Green synthesis and anxiolytic activity of some new dibenz-[1,4] diazepine-1-one analogues

AbstractA facile, green approach for the synthesis of some new dibenz[1,4]-diazepine-1-one by a three component reaction of Diamine, 1,3 diketone and aromatic aldehyde using oxalic acid as catalyst in water is described. The products are formed in good yields (92–94%). Newly synthesized dibenz [1,4]-diazepine-1-one analogues were evaluated for the anxiolytic activity by the elevated plus maze method. From the activity data it is observed that compounds, 4g, 4h and 4k show promising anxiolytic activity

Microwave-assisted solvent-free one pot synthesis of isobenzofuran-1(3H)-ones using sulphamic acid catalyst

Use of sulphamic acid for the synthesis of isobenzofuran-1(3H)-ones from 2-carboxybenzaldehyde and substituted cyclic as well as non-cyclic ketones in good yield has been demonstrated. Sulphamic acid proved to be an excellent catalyst for this condensation reaction. Reaction has been carried out by both conventional and microwave methods