Shape Instabilities in the Dynamics of a Two-component Fluid Membrane

We study the shape dynamics of a two-component fluid membrane, using a dynamical triangulation monte carlo simulation and a Langevin description. Phase separation induces morphology changes depending on the lateral mobility of the lipids. When the mobility is large, the familiar labyrinthine spinodal pattern is linearly unstable to undulation fluctuations and breaks up into buds, which move towards each other and merge. For low mobilities, the membrane responds elastically at short times, preferring to buckle locally, resulting in a crinkled surface.Comment: 4 pages, revtex, 3 eps figure

A Novel Monte Carlo Approach to the Dynamics of Fluids --- Single Particle Diffusion, Correlation Functions and Phase Ordering of Binary Fluids

We propose a new Monte Carlo scheme to study the late-time dynamics of a 2-dim hard sphere fluid, modeled by a tethered network of hard spheres. Fluidity is simulated by breaking and reattaching the flexible tethers. We study the diffusion of a tagged particle, and show that the velocity autocorrelation function has a long-time $t^{-1}$ tail. We investigate the dynamics of phase separation of a binary fluid at late times, and show that the domain size $R(t)$ grows as $t^{1/2}$ for high viscosity fluids with a crossover to $t^{2/3}$ for low viscosity fluids. Our scheme can accomodate particles interacting with a pair potential $V(r)$,and modified to study dynamics of fluids in three dimensions.Comment: Latex, 4 pages, 4 figure

BAMarray™: Java software for Bayesian analysis of variance for microarray data

BACKGROUND: DNA microarrays open up a new horizon for studying the genetic determinants of disease. The high throughput nature of these arrays creates an enormous wealth of information, but also poses a challenge to data analysis. Inferential problems become even more pronounced as experimental designs used to collect data become more complex. An important example is multigroup data collected over different experimental groups, such as data collected from distinct stages of a disease process. We have developed a method specifically addressing these issues termed Bayesian ANOVA for microarrays (BAM). The BAM approach uses a special inferential regularization known as spike-and-slab shrinkage that provides an optimal balance between total false detections and total false non-detections. This translates into more reproducible differential calls. Spike and slab shrinkage is a form of regularization achieved by using information across all genes and groups simultaneously. RESULTS: BAMarray™ is a graphically oriented Java-based software package that implements the BAM method for detecting differentially expressing genes in multigroup microarray experiments (up to 256 experimental groups can be analyzed). Drop-down menus allow the user to easily select between different models and to choose various run options. BAMarray™ can also be operated in a fully automated mode with preselected run options. Tuning parameters have been preset at theoretically optimal values freeing the user from such specifications. BAMarray™ provides estimates for gene differential effects and automatically estimates data adaptive, optimal cutoff values for classifying genes into biological patterns of differential activity across experimental groups. A graphical suite is a core feature of the product and includes diagnostic plots for assessing model assumptions and interactive plots that enable tracking of prespecified gene lists to study such things as biological pathway perturbations. The user can zoom in and lasso genes of interest that can then be saved for downstream analyses. CONCLUSION: BAMarray™ is user friendly platform independent software that effectively and efficiently implements the BAM methodology. Classifying patterns of differential activity is greatly facilitated by a data adaptive cutoff rule and a graphical suite. BAMarray™ is licensed software freely available to academic institutions. More information can be found at

LESS-WEIGHT AIRCRAFT WING DESIGN FRAMEWORK USING REINFORCED MATERIAL

The primary number of materials in aircraft construction continues to be wood, steel, aluminum alloys and much more lately, titanium alloys and fiber reinforced composites. Several factors influence selecting material which strength allied to lightness is an essential. Subsonic aircraft can be used as business jets and commercial airplanes. The wings are often straight or with low sweep position. Composite materials are very well recognized for their excellent mixture of high structural stiffness and occasional weight.CFC is viewed to possess a modulus two times &strength three occasions those of aluminum alloy, the traditional materials in aircraft construction. In the studies conducted concerning the fat loss, it's believed that substitute of Al. alloy by CFC leads to 52.96% saving within the total structural weight from the aircraft wing. In our work the aircraft wing components skin is examined thinking about both isotropic and composite materials. The parametric study conducted using MSc Nastran finite element package

Clinical characteristics and laboratory profile of childhood systemic lupus erythematosus in a tertiary care center

Objectives: To study the clinical characteristics and laboratory profile of systemic lupus erythematosus (SLE) in children in a tertiarycare center. Methods: Children presenting to our tertiary care center with suspected SLE, fulfilling at least 4 out of 11 American Collegeof Rheumatology (ACR) criteria for the diagnosis of SLE were reviewed retrospectively. The study period was from June 2012 to May2015. The clinical presentation and laboratory parameters were analyzed. Results: A total of 14 patients fulfilled the ACR criteria; therewere 12 girls and 2 boys with a sex ratio of 1:6 favoring girls. The mean age on presentation was 9.8 years with a range of 3-15 years.At presentation, 70% of the children had features not suggestive of SLE. The most common symptom was fever seen in 100% of thepatients, followed by hematological abnormalities in 78%, and renal involvement in 57% patients. Arthritis, skin lesions, and pulmonaryinvolvement were seen in 42% of the patients. The gastrointestinal presentation was seen in 21% of the patients. Conclusion: SLE has avaried clinical presentation depending on the predominant organ involved. A high index of suspicion is required for the early diagnosisof SLE in children

Study of sleep problems and their association with scholastic performance in school going children

Background: Sleep is an integral part of any healthy individual and sleep problems can affect the intellectual abilities including theperformance at school. Objectives: We studied the sleep problems among school going children in the age group of 6-16 years and theassociation of the sleep problems with scholastic performance in them. Materials and Methods: The study was a cross-sectional studycarried out in students attending a private school. The children were given a questionnaire based on the “BEARS” screening tool forsleep problems in children to be filled by children and parents. Accordingly, the age and academic grades of students were recorded.The prevalence of sleep problems and their relation to school grades were studied. Results: Out of 229 students, 25.33% (58) studentswere found to have sleep problems after applying the “BEARS” criteria. Of these 58 children, 31 scored A grade, 25 scored B grade, and2 scored C grade. 23% (31 out of 135) of A graders were found to have sleeping problems, 28% (25 out of 89) of B graders, and 40%(2 out of 5) of C graders had sleeping problems. Conclusion: Sleep problems were common in school going children. It was observedthat as scholastic grades decreased, the prevalence of sleeping problems increased. Sleep problems might be one of the contributors forpoor scholastic achievements in children

Deltamethrin Contact Exposure Mediated Toxicity and Histopathological Aberrations in Tissue Systems of Public Health Importance Cockroach Species Periplaneta americana and Blattella germanica

Cockroach species Periplaneta americana and Blattella germanica potentially survive in locations close to human activity. Besides spoiling food material, cockroaches also transfer pathogens of different diseases among human beings. Since the insecticides have been used extensively to control cockroaches, information on their insecticide susceptibility and toxicity at the cellular level may be crucial. In the study, deltamethrin toxicity as well as the deltamethrin-mediated cytomorphological changes in the brain, ovary and midgut of the two important cockroach species have been assessed. Different concentrations [0.00025% (0.0025 mg/ml), 0.0025% (0.025 mg/ml), 0.025% (0.25 mg/ml), 0.25% (2.5 mg/ml), 0.5% (5 mg/ml), 1% (10 mg/ml)] of deltamethrin in acetone were used to expose test species in WHO bottle assay. Knockdown was recorded after 5 min interval while delayed mortality was observed after 24 h. Brain, ovary and gut were dissected post 1 h exposure and 24 h holding (for 0.25, 0.5 and 1% concentration), and tissues were processed for microscopic analysis. Deltamethrin exposed cockroaches and dissected tissues were used to estimate deltamethrin using HPLC. At 0.00025% (lowest concentration), the percentage knock-down observed was 66.7% for P. americana and 80% B. germanica respectively (R2 = 0.78; p = 0.0001) in 1 h. KDT50 value was found to be 8.7 min (95% CI: 7.3–10.2), while KDT99 was 20.7 min (95% CI: 16.0–35.7) in P. americana at 1% concentration. Whereas, the KDT50 and KDT99 values for B. germanica were 7.4 min (95% CI: 5.4–9.1) and 27.4 min (95% CI: 18.2–80.0) at a similar concentration. LD50 and LD95 values (for 60 min standard exposure) were 0.0006% (95% CI: 0.00–0.001) and 0.034% (95% CI: 0.013–0.49) respectively for P. americana, while these values were 0.0005 (95% CI: 0.00–0.001) and 0.04 (95% CI: 0.01–0.23) for B. germanica. Exposure to 1% deltamethrin induced a considerable toxic effect in the epithelial cells in the midgut. HPLC estimated 0.21 ± 0.05 mg (95% CI: 0.18–0.25; CoV 23.9%) deltamethrin in P. americana post 1% exposure. Even short term exposure to a low concentration of synthetic pyrethroid deltamethrin displayed immediate knockdown and delayed mortality in both the test species. Considerable histological damage was observed in both the insects at 1% exposure. In India, resistance to deltamethrin may have been reported among different insects due to its extensive use. However, the formulations such as insecticide paints, attractant baits etc. developed using deltamethrin as an active ingredient could be useful in cockroach control operations