539 research outputs found

    Single-Copy Certification of Two-Qubit Gates without Entanglement

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    A quantum state transformation can be generally approximated by single- and two-qubit gates. This, however, does not hold with noisy intermediate-scale quantum technologies due to the errors appearing in the gate operations, where errors of two-qubit gates such as controlled-NOT and SWAP operations are dominated. In this work, we present a cost efficient single-copy certification for a realization of a two-qubit gate in the presence of depolarization noise, where it is aimed to identify if the realization is noise-free, or not. It is shown that entangled resources such as entangled states and a joint measurement are not necessary for the purpose, i.e., a noise-free two-qubit gate is not needed to certify an implementation of a two-qubit gate. A proof-of-principle demonstration is presented with photonic qubits.Comment: 8 pages. arXiv admin note: text overlap with arXiv:1812.0208

    Experimental Study on Reinforced Concrete Column Incased in Prefabricated Permanent Thin-Walled Steel Form

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    Conventional construction methods of reinforced concrete (RC) structures generally require a long construction period and high costs due to many on-site temporary form works. In this study, a prefabricated permanent thin-walled steel form integrated with reinforcement cage (PPSFRC) was developed, and it makes for a fast-built construction by reducing the temporary form works. Axial compression tests were conducted on a total of 9 test specimens to investigate the structural performances of the newly developed columns. The proposed column construction method utilized relatively thinner steel plates compared to conventional concrete-filled tube (CFT) columns, but it was designed to have sufficient resistance performances against the lateral pressure of fresh concrete and to prevent the buckling of the thin plates by utilizing the steel angles and channel stiffeners prefabricated in the permanent thin-walled steel form. The experimental results showed that the column specimens fabricated by the PPSFRC method had better local buckling resistance and behaved in a more ductile manner compared to the conventional CFT columns. In addition, the axial strengths of the test specimens were compared with those estimated by design provisions, and the flexural moments induced by initial imperfection or accidental eccentricity of axial loads were also discussed in detail

    Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis

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    <p>Abstract</p> <p>Background</p> <p>In contrast to tumor-suppressive apoptosis and autophagic cell death, necrosis promotes tumor progression by releasing the pro-inflammatory and tumor-promoting cytokine high mobility group box 1 (HMGB1), and its presence in tumor patients is associated with poor prognosis. Thus, necrosis has important clinical implications in tumor development; however, its molecular mechanism remains poorly understood.</p> <p>Results</p> <p>In the present study, we show that Distal-less 2 (Dlx-2), a homeobox gene of the Dlx family that is involved in embryonic development, is induced in cancer cell lines dependently of reactive oxygen species (ROS) in response to glucose deprivation (GD), one of the metabolic stresses occurring in solid tumors. Increased Dlx-2 expression was also detected in the inner regions, which experience metabolic stress, of human tumors and of a multicellular tumor spheroid, an <it>in vitro </it>model of solid tumors. Dlx-2 short hairpin RNA (shRNA) inhibited metabolic stress-induced increase in propidium iodide-positive cell population and HMGB1 and lactate dehydrogenase (LDH) release, indicating the important role(s) of Dlx-2 in metabolic stress-induced necrosis. Dlx-2 shRNA appeared to exert its anti-necrotic effects by preventing metabolic stress-induced increases in mitochondrial ROS, which are responsible for triggering necrosis.</p> <p>Conclusions</p> <p>These results suggest that Dlx-2 may be involved in tumor progression via the regulation of metabolic stress-induced necrosis.</p

    Clinical and Radiological Outcomes of Modified Phemister Operation with Coracoclavicular Ligament Augmentation Using Suture Anchor for Acute Acromioclavicular Joint Dislocation

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    Background Modified Phemister operation has been widely used for the treatment of acute acromioclavicular (AC) joint dislocation. Additionally, the use of suture anchor for coracoclavicular (CC) fixation has been reported to provide CC stability. This study was conducted to evaluate the clinical and radiological results of a modified Phemister operation with CC ligament augmentation using suture anchor for acute AC joint dislocation. Methods Seventy-four patients underwent the modified Phemister operation with CC ligament augmentation using suture anchor for acute AC joint dislocation and were followed-up for an average of 12.3 months. The visual analogue scale (VAS), range of motion, Constant score, and Korean shoulder scoring system (KSS) were used for clinical assessment. Acromioclavicular interval (ACI), coracoclavicular distance (CCD), and acromioclavicular distance (ACD) were obtained to evaluate the radiological assessments. Results At the last follow-up, the mean VAS Score was 1.7 points, the mean joint range of the forward flexion was 164.6°, external rotation at the side was 61.2°, and internal rotation to the posterior was a level of T12. The mean Constant score and the mean KSS was 82.7 points and 84.2 points, respectively. At the mean ACI, CCD, and ACD, significant differences were found preoperatively and at the last follow-up. When the ACI, CCD, and ACD were compared with the contralateral unaffected shoulder at the last follow-up, the affected shoulders had significantly higher values. Conclusions The modified Phemister operation with CC ligament augmentation using suture anchor is clinically and radiologically effective at acute AC joint dislocation

    Real-time heart rate variability according to ambulatory glucose profile in patients with diabetes mellitus

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    BackgroundAutonomic neuropathy commonly occurs as a long-term complication of diabetes mellitus (DM) and can be diagnosed based on heart rate variability (HRV), calculated from electrocardiogram (ECG) recordings. There are limited data on HRV using real-time ECG and ambulatory glucose monitoring in patients with DM. The aim of this study was to investigate real-time HRV according to ambulatory glucose levels in patients with DM.MethodsA total of 43 patients (66.3 ± 7.5 years) with DM underwent continuous real-time ECG monitoring (225.7 ± 107.3 h) for HRV and ambulatory glucose monitoring using a remote monitoring system. We compared the HRV according to the ambulatory glucose profile. Data were analyzed according to the target in glucose range (TIR).ResultsThere were no significant differences in the baseline characteristics of the patients according to the TIR. During monitoring, we checked ECG and ambulatory glucose levels (a total of 15,090 times) simultaneously for all patients. Both time- and frequency-domain HRVs were lower when the patients had poorly controlled glucose levels (TIR &lt; 70%) compared with well controlled glucose levels (TIR &gt; 70%). In addition, heart and respiratory rates increased with real-time glucose levels (P &lt; 0.001).ConclusionsPoorly controlled glucose levels were independently associated with lower HRV in patients with DM. This was further substantiated by the independent continuous association between real-time measurements of hyperglycemia and lower HRV. These data strongly suggest that cardiac autonomic dysfunction is caused by elevated blood sugar levels

    Diffusion Decay Coefficient for Chloride Ions of Concrete Containing Mineral Admixtures

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    The diffusion coefficient for chloride ions and the diffusion decay coefficient for chloride ions are essential variables for a service life evaluation of concrete structures. They are influenced by water-binder ratio, exposure condition, curing temperature, cement type, and the type and use of mineral admixture. Mineral admixtures such as ground granulated blast furnace slag, fly ash, and silica fume have been increasingly used to improve resistance against chloride ions penetration in concrete structures built in an offshore environment. However, there is not enough measured data to identify the statistical properties of diffusion decay coefficient for chloride ions in concrete using mineral admixtures. This paper is aimed at evaluating the diffusion decay coefficient for chloride ions of concrete using ordinary Portland cement or blended cement. NT BUILD 492 method, an electrophoresis experiment, was used to measure the diffusion coefficient for chloride ions with ages. It was revealed from the test results that the diffusion decay coefficient for chloride ions was significantly influenced by W/B and the replacement ratio of mineral admixtures

    Strong ferromagnetism in Pt-coated ZnCoO: The role of interstitial hydrogen

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    We observed strong ferromagnetism in ZnCoO as a result of high concentration hydrogen absorption. Coating ZnCoO with Pt layer, and ensuing hydrogen treatment with a high isostatic pressure resulted in a highly increased carrier concentration of 10(21)/cm(3). This hydrogen treatment induced a strong ferromagnetism at low temperature that turned to superparamagnetism at about 140 K. We performed density functional method computations and found that the interstitial H dopants promote the ferromagnetic ordering between scattered Co dopants. On the other hand, interstitial hydrogen can decrease the magnetic exchange energy of Co-H-Co complexes, leading to a reduction in the blocking temperature.open7

    Effect of volatile fatty acid concentration on anaerobic degradation rate from field anaerobic digestion facilities treating food waste leachate in

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    The purpose of this study was to investigate the effect of volatile fatty acid concentration on anaerobic degradation rate of food waste leachate in the anaerobic digestion facilities. The anaerobic digestion facilities treating food waste leachate (FWL), codigestion with food leachate and animal manure (A-MIX), and codigestion with food waste leachate and sewage sludge (S-MIX) were selected for this study. In accordance with the regulation under Wastes Control Act in South Korea, the guideline of volatile solid removal rate for anaerobic digestion facility is set as 65% for anaerobic degradation efficiency. Highest volatile solids removal rates were achieved from FWL (63.5%) than A-MIX (56.4%) and S-MIX (41.2%). Four out of eight FWLs met the guidelines. The concentration of volatile fatty acids, therefore, was analyzed to determine the relationship with volatile solid removal rate. The results showed that, in order to meet the Korean guideline of 65% volatile solid removal rate, volatile fatty acid concentrations should remain below 4,000 mg/L on the field anaerobic digestion facilities treating FWL. Volatile fatty acid concentrations should be used along with others as an operational parameter to control and manage the anaerobic digestion process
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