52 research outputs found
Clinical Study of Nirgundi Ghana Vati with Nirgundi Patra Panda Sweda in the management on Amavata
Today as man is climbing the step of success, he is moving away from health abnormal food habits, style of living, greed, anger have become a part of his life. The sedentary life style has given birth to number of diseases. Amavata is one of the challenging diseases for the physicians due to its chronicity, incurability, complications and morbidity. Amavata (Rheumatoid arthritis) the term desires from the words as “Ama ” and “Vata” the word Ama is the condition which in various ailments in system due to its toxic effect. The Ama when combines with Vatadosha and occupies in Shleshmasthana (Asthi Sandhi) results painful disease ‘Amavata’ The disease is characterized by various features like Sandhishoola in the nature of Toda, swelling inability of joints movements etc. In this research work 16 patients were registered, these patients were given Nirgundi Ghan Vati in the doses of 500gm two Vati three times a day for 30 days, along with Nirgundi Patra Pinda Sweda in 28 days. Results show that significant decrease in the symptoms of Amavata after treatment regimen
Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis.
Epithelial-to-mesenchymal transition (EMT) has been implicated in the progression of bladder cancer. To study its contribution to bladder cancer metastasis, we established new xenograft models derived from human bladder cancer cell lines utilizing an orthotopic "recycling" technique that allowed us to isolate and examine the primary tumor and its corresponding circulating tumor cells (CTC's) and metastatic lesions. Using whole genome mRNA expression profiling, we found that a reversible epithelial-to-mesenchymal transition (EMT) characterized by TGFβ pathway activation and SNAIL expression was associated with the accumulation of CTCs. Finally, we observed that conditional silencing of SNAIL completely blocked CTC production and regional/distant metastasis. Using this unique bladder cancer xenograft model, we conclude that metastasis is dependent on a reversible EMT mediated by SNAIL
Realized ecological forecast through an interactive Ecological Platform for Assimilating Data (EcoPAD, v1.0) into models
Predicting future changes in ecosystem services is not only highly
desirable but is also becoming feasible as several forces (e.g., available big
data, developed data assimilation (DA) techniques, and advanced
cyber-infrastructure) are converging to transform ecological research into
quantitative forecasting. To realize ecological forecasting, we have
developed an Ecological Platform for
Assimilating Data (EcoPAD, v1.0) into models. EcoPAD (v1.0)
is a web-based software system that automates data transfer and processing
from sensor networks to ecological forecasting through data management,
model simulation, data assimilation, forecasting, and visualization. It
facilitates interactive data–model integration from which the model is
recursively improved through updated data while data are systematically
refined under the guidance of model. EcoPAD (v1.0) relies on data from
observations, process-oriented models, DA techniques, and the web-based
workflow.
We applied EcoPAD (v1.0) to the Spruce and Peatland Responses Under Climatic
and Environmental change (SPRUCE) experiment in northern Minnesota. The
EcoPAD-SPRUCE realizes fully automated data transfer, feeds meteorological
data to drive model simulations, assimilates both manually measured and
automated sensor data into the Terrestrial ECOsystem (TECO) model, and
recursively forecasts the responses of various biophysical and biogeochemical
processes to five temperature and two CO2 treatments in near-real time
(weekly). Forecasting with EcoPAD-SPRUCE has revealed that mismatches in
forecasting carbon pool dynamics are more related to model (e.g., model
structure, parameter, and initial value) than forcing variables, opposite to
forecasting flux variables. EcoPAD-SPRUCE quantified acclimations of methane
production in response to warming treatments through shifted posterior
distributions of the CH4:CO2 ratio and the temperature sensitivity
(Q10) of methane production towards lower values. Different case
studies indicated that realistic forecasting of carbon dynamics relies on
appropriate model structure, correct parameterization, and accurate external
forcing. Moreover, EcoPAD-SPRUCE stimulated active feedbacks between
experimenters and modelers to identify model components to be improved and
additional measurements to be taken. It has become an interactive
model–experiment (ModEx) system and opens a novel avenue for interactive
dialogue between modelers and experimenters. Altogether, EcoPAD (v1.0) acts
to integrate multiple sources of information and knowledge to best inform
ecological forecasting.</p
Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes?:Systematic review
background: It is unclear whether more timely cancer diagnosis brings favourable outcomes, with much of the previous evidence, in some cancers, being equivocal. We set out to determine whether there is an association between time to diagnosis, treatment and clinical outcomes, across all cancers for symptomatic presentations. methods: Systematic review of the literature and narrative synthesis. results: We included 177 articles reporting 209 studies. These studies varied in study design, the time intervals assessed and the outcomes reported. Study quality was variable, with a small number of higher-quality studies. Heterogeneity precluded definitive findings. The cancers with more reports of an association between shorter times to diagnosis and more favourable outcomes were breast, colorectal, head and neck, testicular and melanoma. conclusions: This is the first review encompassing many cancer types, and we have demonstrated those cancers in which more evidence of an association between shorter times to diagnosis and more favourable outcomes exists, and where it is lacking. We believe that it is reasonable to assume that efforts to expedite the diagnosis of symptomatic cancer are likely to have benefits for patients in terms of improved survival, earlier-stage diagnosis and improved quality of life, although these benefits vary between cancers
Do African-American men need separate prostate cancer screening guidelines?
BACKGROUND: In 2012, the United States Preventative Services Task Force issued new guidelines recommending that male U.S. residents, irrespective of race, no longer be screened for prostate cancer. In African American men, the incidence of prostate cancer is almost 60 % higher and the mortality rate is two to three times greater than in Caucasians. The purpose of this study is to reduce African American men's prostate cancer burden by demonstrating they need separate screening guidelines. METHODS: We performed a PubMed search using the keywords: African American, Prostate cancer, Outcomes, Molecular markers, Prostate-specific Antigen velocity, PSA density, and to derive data relevant to our hypothesis. RESULTS: In our literature review, we identified several aspects of prostate cancer that are different in Caucasian and African American men. These included prostate cancer incidence and outcome, the clinical course of the disease, serum PSA levels, genetic differences, and social barriers. It's also important to note that the USPSTF guidelines were based on two studies, one of which reported that only 4 % of its participants were African American. The other did not report demographic information, but used participants from seven European countries with small African American populations. CONCLUSION: Given the above, we conclude that separate prostate cancer screening guidelines are greatly necessary to help save the lives of African Americans
BCG-unresponsive non-muscle-invasive bladder cancer: recommendations from the IBCG
Item does not contain fulltextIntravesical immunotherapy with live attenuated BCG remains the standard of care for patients with high-risk and intermediate-risk non-muscle-invasive bladder cancer (NMIBC). Most patients initially respond, but recurrence is frequent and progression to invasive cancer is a concern. No established and effective intravesical therapies are available for patients whose tumours recur after BCG, representing a clinically important unmet need. Development and discovery of treatment options for BCG-unresponsive NMIBC is a high priority in order to decrease the morbidity, burden of health-care expenditures, and mortality related to bladder cancer. This Review of treatment options after BCG failure focuses on principles of optimal management emerging therapies, thus enabling a synthesis of recommendations for management for such patients
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