2 research outputs found
Maternal fetal immunological relationship particularly mycobacterial immunity
Thirty-nine paired maternal and cord blood
from normal full term deliveries were tested for
lymphocyte function by proliferative response to
mitogens β Phytohemagluttin-P (PHA) and
Poke weed mitogens (PWM). Monocyte function
was assessed by the ability of the monocytes to release
hydrogen peroxide (H 2O2 ) in response to
standard stimulus (PMA). Mycobacterial immunity
was assessed by lymphocyte proliferative response
to purified proteins derivative (PPD) and
IgM and IgG antibody response to H37Rv and 5
atypical mycobacteria.
Lymphocyte functions were significantly
lower in cord blood (PHA 20.6, PWM 21.2) as
compared with maternal blood (PHA 65.8, PWM
37.8). The capacity of fetal monocytes to release
H2O2 was comparable to maternal monocytes.
The mean proliferative response of fetal lymphocytes
to tubercular protein (PPD) was 0.67 as
compared (P< 0.01) tO maternal lymphocytes
(3.79). Nearly 86% of the cord blood did not
show any response to PPD. None of the cord
blood showed IgM antibody response to H37RV
nor to any of the range of 5 atypical mycobacteria
though maternal IgM and IgG response was
present. There was only passive transfer of IgG
antibody from mother to fetus.
Hence, though this is a highly endemic area
for atypical mycobacteria and M. tuberculosis,
there was apparently 170 transplacental transfer of
antigen in normal sensitized mothers
Osteomas of ethmoidal sinuses
Three cases of osteomas of ethmoid are reported along with a brief review of literature