Efficient Privacy on Personalized Web Search Using Web Transformation Technique in User Profile

The time required for query processing over the internet is high due to the massively increasing amount of data on the server. Sometimes we may get irrelevant information as a result for a query. So we go for Personalized Web Search (PWS) to make the query processing good. In PWS, the query processing is done with the help of user profile. The user profile is created in two manners namely implicit and explicit. The implicit method creates the user profile from user’s browser histories, email, document and etc., without any effort from the user. Through this method the profile created with some user’s personal and secret information. Exposure of secret information on web leads to the privacy problem. In another way that the profile was created by explicit method. In this method the users requested to create their profile manually on the web. After profile creation the query processing is takes place. At each time a query is generated by a user that is combined with the personalized profile to generate a personalized query. Now the generalized query is send to the server. The server process the query then ranks the collected information. Finally the results are given to the client side and viewed to the user. The profile is updated in both ways at each time of query processing (automatically) and also by the manual update. To increase the privacy protection the profile details is reviewed at users own time. They can hide their secret information from the profile. Each profile updating process checks the newly added field information with the already hided field information. If any newly added field information matches with the personalized information then a notification is generated automatically to alert the user to personalize their profile. DOI: 10.17762/ijritcc2321-8169.15060

3-(2-Meth­oxy­naphthalen-1-yl)-2-benzofuran-1(3H)-one

The asymmetric unit of the title compound, C19H14O3, contains two crystallographically independent mol­ecules in which the dihedral angles between the naphthalene and benzofuran ring systems are 76.49 (7) and 86.17 (7)°. In the crystal, mol­ecules are linked by inter­molecular C—H⋯O hydrogen-bonding inter­actions into chains running parallel to the a axis. In addition, the crystal packing is stabilized by C—H⋯π inter­actions

Formulation and Evaluation of Floating Tablets of Sitagliptin with Extract of Triphala

The aim of the present work is to formulate, optimize and evaluate hydrodynamically balanced antidiabetic system incorporated with sitagliptin and phytochemical constituents of Triphala extract for the treatment of constipation associated with diabetes.  The Triphala churna of two different ratios, 1:1:1 (TC1) and 1:2:4 (TC2) were subjected to hot percolation using Soxhlet apparatus using methanol as solvent. The floating matrix tablets of Sitagliptin with methanolic Triphala extract was prepared by wet granulation technique using HPMC K4M as polymer, starch/honey as binder and sodium bicarbonate & citric acid as effervescent agents by 24 factorial design.  The compatibility studies showed that there is no chemical interaction between the drug, polymer and the excipients used in the tablets.  The independent variables are drug & Triphala extract ratio (X1), Triphala proportion (X2), binder used for granulation (X3), and amount of effervescent excipients used (X4).  The dependent variables are hardness (Y1), buoyancy lag time (Y2), total floating time (Y3), in-vitro drug release (Y4), and T50% (Y5).  The prepared floating tablets were subjected to all post compression parameters such as hardness, friability, swelling capacity, buoyancy, total floating time, drug content & in-vitro drug release and were found to be within normal limits.  Based on drug content, buoyancy lag time and in-vitro drug release the formulations F14 and F16 were selected for in-vivo study of the formulation.  Keywords:  Triphala, Sitagliptin, honey, floating tablet.&nbsp

ACUTE TOXICITY AND IN-VIVO LAXATIVE STUDIES OF THE TRIPHALA EXTRACT IN EXPERIMENTAL ANIMALS

Triphala has been extensively used in traditional medicine for laxative, antidiabetic, expectorant, astringent, anti-aging etc.  The acute toxicity of methanolic extracts of Triphala in 300 mg, 600 mg, and 1000 mg/kg has not yet been studied.  The current studies were done by employing Swiss Albino mice as experimental animal. The methanolic extracts of Triphala were considered safe up to a dose of 1000 mg/kg when evaluated for acute oral toxicity in accordance with the OECD (Organization for Economic Cooperation and Development) guidelines. The results of acute toxicity showed no signs of toxicity such as general behaviour changes, mortality, changes on gross appearance or histopathological changes of the internal organs of rats. The examinations of signs of acute toxicity showed no abnormalities in the test groups as compared to the controls. Haematological and blood chemical values in treated groups were normal in comparison with the control group.  Therefore, the extract of Triphala given orally to mice did not produce acute toxicities.  The laxative activity on Albino Wistar rats shows that the Triphala extract has significant positive effect on constipated animals. &nbsp

DETERMINATION OF ALLICIN IN ALLIUM SATIVUM USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND STUDY OF GENOTOXIC EFFECT ON HUMAN LEUKOCYTES

Objectives: Allicin is an organosulfur compound featuring thiosulfinate functional group. The compound is formed in garlic after tissue damage, bythe action of enzyme alliinase on alliin. This study involves extraction of allicin from garlic using high-performance liquid chromatography (HPLC) andstudy of it is the genotoxic effect on human leukocytes.Methods: A simple and rapid reverse phase HPLC was used for the extraction of allicin. Quality allicin, in conjugation with chymosin, was used tostudy its genotoxic effect on leukocytes.Results: Garlic oil and garlic extract showed similar retention time, and we measured the products using genotoxic effects in human leukocyte cultureand it shows statistically not significant.Conclusion: This study suggested that to take a lower concentration of garlic extracts benefits for health and these findings useful for further research.Keywords: Allium sativum, Leukocytes, Chromosome, Genotoxic, High-performance liquid chromatography

NaGaSe2: A Water-Loving Multifunctional Non-Van Der Waals Layered Selenogallate

A Missing Member of Well-Known Ternary Chalcometallates, a Sodium Selenogallate, NaGaSe2, Has Been Synthesized by Employing a Polyselenide Flux and Stoichiometric Reaction. Crystal Structure Analysis using X-Ray Diffraction Techniques Reveals that It Contains Supertetrahedral Adamantane-Type Ga4Se10 Secondary Building Units. These Ga4Se10 Secondary Building Units Are Further Connected Via Corners to Form Two-Dimensional (2D) [GaSe2]∞- Layers Stacked Along the C-Axis of the Unit Cell, and the Na Ions Reside in the Interlayer Space. the Compound Has an Unusual Ability to Absorb Water Molecules from the Atmosphere or a Nonanhydrous Solvent to Form Distinct Hydrated Phases, NaGaSe2·xH2O (Where X Can Be 1 and 2), with an Expanded Interlayer Space, as Verified by X-Ray Diffraction (XRD), Thermogravimetric-Differential Scanning Calorimetry (TG-DSC), Desorption, and Fourier Transform Infrared Spectroscopy (FT-IR) Studies. the in Situ Thermodiffractogram Indicates the Emergence of an Anhydrous Phase Before 300 °C with the Decrease of Interlayer Spacings and Reverting to the Hydrated Phase within a Minute of Re-Exposure to the Environment, Supporting the Reversibility of Such a Process. Structural Transformation Induced through Water Absorption Results in an Increase of Na Ionic Conductivity by 2 Orders of Magnitude Compared to that of the Pristine Anhydrous Phase, as Verified by Impedance Spectroscopy. Na Ions from NaGaSe2 Can Be Exchanged in the Solid-State Route with Other Alkali and Alkaline Earth Metals in a Topotactic or Nontopotactic Way, Leading to 2D Isostructural and Three-Dimensional Networks, Respectively. Optical Band Gap Measurements Show a Band Gap of ∼3 EV for the Hydrated Phase, NaGaSe2·xH2O, Which is in Good Agreement with the Calculated Band Gap using a Density Functional Theory (DFT)-Based Method. Sorption Studies Further Confirm the Selective Absorption of Water over MeOH, EtOH, and CH3CN with a Maximum Water Uptake of 6 Molecules/formula Unit at a Relative Pressure, P/P0, of 0.9

(4-Methyl­phen­yl)[2-(thio­phen-2-ylcarbon­yl)phen­yl]methanone

The crystal studied of the title compound, C19H14O2S, was an inversion twin with a 0.7 (1):0.3 (1) domain ratio. The central benzene ring makes dihedral angles of 63.31 (9) and 60.86 (9)°, respectively, with the 4-methyl­phenyl and thio­phene rings. In the crystal, mol­ecules are linked by weak inter­molecular C—H⋯O hydrogen bonds and S⋯π [3.609 (3) Å] inter­actions