Non syndromic synchronous multiple odontogenic keratocysts in a western Indian population : a series of four cases

Odontogenic keratocysts (OKCs) are developmental odontogenic cysts affecting the maxillofacial region and their association with a syndrome especially Naevoid basal cell carcinoma syndrome (NBCCS) is a common occurrence in comparison to non syndromic multiple OKCs. In a first, we present a series of four non syndromic cases with multiple OKCs in western Indian population. The presence of multiple OKC in our present case series may be because of the multifocal nature of the lesion rather than its association with any syndrome. Thus, a comprehensive evaluation of any patients reporting with multiple cysts/OKCs always has to be undertaken and the dental practitioner may be the play a key role in early detection and subsequent follow-up

Methods of Collection and Transport of Materials to Laboratory from Oral and Dental Tissue Lesions

The oral pathology laboratory is the most resourceful place for the diagnosis of oral lesions. Most clinicians err on the collection and transport of oral and associated tissues to the laboratory. Oral tissue examination includes a wide range such as oral biopsy (for routine formalin fixed and fresh tissue), saliva, swabs, cytology smears and fine needle-aspirated, cystic fluid. This in turn adversely affects the final diagnosis of the disease. Thus, it is high time to appreciate and acknowledge the role of collection containers, fixing reagents and transport media as an adjunct for successful diagnosis

A Review of Salivary Biomarker: A Tool for Early Oral Cancer Diagnosis

The oral squamous cell carcinoma (OSCC) is one of the most common epithelial malignancies with significant morbidity and mortality. Recent observations indicate that the clinical and histological appearance of oral mucosa may not truly depict the damage occurring at the genetic level. This phenotypic and genotypic disparity may account in part for the failure to establish effective screening and surveillance protocols, based on the traditional clinical and microscopic examination. The tumor markers are playing an increasingly important role in cancer detection and management. These laboratory-based tests are potentially useful in screening for early malignancy, aiding in cancer diagnosis, determining prognosis, surveillance following curative surgery for cancer, up-front predicting drug response or resistance, and monitoring therapy in advanced disease. A systematic review of the literature was performed based on the English titles listed in the PubMed, EBSCO, Cochrane, Science Direct, ISI web Science, and SciELO databases using the keywords. Abstracts and full-text articles were assessed. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis in the high-risk patients with the OSCC

Comparison of hematological parameters in anemia of chronic disease and chronic periodontitis

Background: Periodontitis is a localized, chronic inflammatory reaction, induced by bacteria, and effect healthy periodontium. The third highest prevalence of periodontal disease in the world is in Asia.6 Infections, malignant cells, and autoimmune dysregulation these all factors lead to the activate the immune system and start production of cytokines. Chronic periodontitis can be a cause of anemia of chronic diseases. Materials and Methods: The study population consisted of 160 individuals between the age groups of 20-70 years, Hemoglobin concentration, Erythrocyte count, Mean corpuscular volume, Mean corpuscular hemoglobin, Mean corpuscular hemoglobin concentration was measured using an automated hematology analyser.  ESR was estimated using Westergren’s method. Serum ferritin was measured on ELISA kit by a semi automated analyser on LISA SCAN. Students “t” test was used for comparing the mean Hb, erythrocyte count, MCV, MCH, MCHC, ESR, and ferritin between the two groups. Results:  The comparison of blood parameters was done among study and control males. Mean value of hemoglobin, RBC, MCH, MCHC, ESR and Serum Ferritin were statistically significant(P<0.001) whereas mean value of MCV was statistically insignificant. The comparison of blood parameters was done among study and control females