PHARMACOLOGY OF NOVAL CANNABINOIDS

Cannabis is a plant rich in various compounds that have a variety of impacts on the physiology of humans and the effects of these metabolites have a significant role in managing a variety of clinical diseases. A substantial increase in the use of SC (synthetic cannabinoids) had seen in the last few years especially infrequent cannabis users. The SCs will generate psychoactive effects that were similar to cannabis. However, the composition and pharmacological characteristics of these drugs make them possibly hazardous. Like all drugs, cannabis’ pharmacokinetics depends on the route of administration. Several studies showed that the bioavailability is less in oral administration when compared to inhalation. The main reason for this decrease in oral bioavailability is that cannabinoids undergo the first-pass metabolism before entering into the systemic circulation whereas in inhalation, it enters the circulation directly through the lungs. Cannabis sativa is a psychoactive plant that contains more than 500 components of which 104 cannabinoids had been identified. Of these, 2 components such as Δ9-THC (Δ9-tetrahydrocannabinol) and CBD (cannabidol) were under the scientific investigation. Δ9-THC is the primary cannabinoid which was responsible for the consequences of psychotrophy. The potency of cannabis is assessed based on the THC concentration of a sample that is the main psychoactive cannabinoid in cannabis. The adverse effects are in direct relation to the concentration of THC in the product after regular cannabis use. It can be assumed that several cannabinoids will find their way into the pharmacies from preclinical research within a century

Assessment and evaluation of drug information services provided by drug information centre at a multispecialty hospital in Erode, Tamil Nadu, India

Background: To evaluate the performance of Drug Information Centre (DIC) in providing quality drug information services to the health care professionals.Methods: It was a prospective study carried out for a period of six months (June-November 2017). The drug information services provided by the pharmacist at the DIC during ward rounds, direct access, telephone and mail were documented in the drug information request and documentation forms. The quality of drug information provided was assessed with the help of feedback questionnaire which was filled by receivers.Results: A total of 283 queries were received, with a maximum from ward rounds 140(49.47%). On evaluation, it was found that most of the queries were from physicians 207 (73.14%) followed by nurses 33(11.66%), pharmacists 26 (9.18%), patients 17 (6.07%). Among that 178 (62.89%) queries were received from department of general medicine. Most of the queries were intended to update knowledge 110 (38.86%) and for the purpose of better patient care 90 (31.81%). The time frame for an authentic reply ranged from minutes to 24 hours, where a maximum of 110 (38.86%) queries had sent a 24 hours deadline. The majority of the queries were for adverse drug reactions [ADR-60 (21.20%)] and most preferred resources were primary 188 (66.43%).Conclusions: The DIC has always presented and offered itself to be an impressive resource, which is used routinely as an information source by all levels of professionals involved in the health system, in addition to the patients themselves

Performance of coconut (Cocos nucifera L.) hybrids for yield and quality in the Utkal plain region of Odisha state, India

Cocos nucifera L. is a perennial oil yielding crop with a long productive life span (>60 years); thus, identifying a suitable high yielding hybrid to a particular agro-climatic region plays a prime role in achieving sustainable coconut yield. In this context, an evaluation trial with varietal cross combinations involving Tall × Dwarf (six crosses) and Dwarf × Tall (two crosses) was conducted at All India Coordinated Research Project (AICRP) on Palms, Bhubaneshwar Centre, Odisha, for 15 years. The experiment was laid out in randomized block design with four replications maintaining six palms per replication. Observations on yield and yield attributing characters during 2018 to 2020 revealed the superior performance of ECT × GBGD (99.1 nuts), which was followed by ECT × MYD (86.9 nuts) over the local check (ECT) by recording higher nut yield. Copra output per palm was significantly the highest under ECT × GBGD (20.6 kg palm-1), followed by LCT × COD (18.6 kg palm-1). Hybrids possessed a higher quantity of organoleptically ‘good’ tender nut water (270.3 to 354.1 mL) with TSS of 5.8 to 6.9 °Brix, 25.4 to 34.0 ppm of sodium and 2065.9 to 2885.0 ppm of potassium

Efficacy and safety of 1% terbinafine hydrochloride versus 2% sertaconazole cream in the treatment of tinea corporis

Background: Tinea corporis is a common superficial dermatophytosis seen in tropical countries. This study was done to compare the efficacy and safety of topical antifungal agents, terbinafine versus sertaconazole in the treatment of tinea corporis.Methods: This study was conducted in Babuji Hospital and Chigateri Government Hospital, Davangere. A total of 60 (n=60) patients were included and divided into two groups of 30 patients each in the study. 1st group - received topical 1% terbinafine hydrochloride and 2nd group - received 2% sertaconazole cream. Patients were advised to apply cream twice daily for 4 weeks. Improvement in clinical parameters like erythema, scaling, itching, and potassium hydroxide (KOH) mount were taken for assessing the efficacy of drugs. They were followed-up at the end of 2, 4, and 6 weeks to assess the improvement of the condition. Complete cure rate was defined as mycological cure with a complete absence of clinical signs and symptoms. For safety data of both drugs presence of any local side effects (like stinging sensation, swelling and increased erythema) were analyzed in both groups. Statistical analysis was done using students paired t-test and unpaired t-test.Results: When two groups were compared at the end of 2 weeks, complete cure rate for terbinafine was 80% as compared to 63.3% for sertaconazole (p0.05) results were obtained. KOH mount was negative in both groups at the end of 2nd week. Local side effects like erythema, swelling, stinging sensation were not noticed during the study in both the groups.Conclusion: From this study, it was shown that 2% sertaconazole cream was as effective as 1% terbinafine cream, though 1% terbinafine had higher rates of complete cure at the end of 2 weeks as compared to sertaconazole

Productivity and carbon sequestration potential of coconut-based cropping system as influenced by integrated nutrient management practices

A field experiment was carried out at Regional Coconut Research Station, Bhatye (DBSKKV, Dapoli), Maharashtra (India) during 2013-2018 to study the productivity and carbon sequestration potential as influenced by integrated nutrient management (INM) practices in coconut based cropping system. INM practices viz., T1- 75 per cent of RDF+25 per cent of N through organic recycling with vermicompost, T2- 50 per cent of RDF+50 per cent of N through organic recycling with vermicompost + vermiwash application + bio-fertilizer application + in situ green manuring (cowpea), T3- fully organic: 100 per cent N through organic recycling with vermicompost + vermiwash application + bio-fertilizer application + in situ green manuring (cowpea) and green leaf manuring + composted coir pith, husk incorporation and mulching with coconut leaves were imposed in coconut based cropping system involving nutmeg, cinnamon, banana and pineapple. For comparison, T4- control: monocrop of coconut with recommended NPK and organic manure was maintained. Four treatments were laid out in a block of 0.45 ha area each. Among the different INM practices, treatment T1 sequestered the highest amount of above ground (coconut + nutmeg) carbon stock (31.1 t ha-1) followed by T2 (30.3 t ha-1) and T3 (27.3 t ha-1). In contrast, the treatment T4 - coconut monocrop alone had sequestered 25.6 t ha-1. The below-ground soil carbon stock in the rhizosphere of different crops was the highest in the nutrient management under T3 followed by T2 and T1, whereas, it was the lowest in coconut monocrop. The productivity of the system was higher in the intercropping garden. The coconut nut yield (5-year average) was higher yield under T1 (147.2 nuts palm-1 year-1), followed by T2 (138.4 nuts palm-1 year-1) and T3 (123.6 nuts palm-1 year-1), whereas, monocrop had recorded a significantly lower number of nuts (97.2 nuts palm-1 year-1)

Heterosis for economic traits in coconut (Cocos nucifera L.)

Field studies conducted for a period of 12 years to assess the traits responsible for yield performance and heterosis of twelve coconut hybrids in comparison with three varieties showed that among the hybrids, GBGD x ECT recorded the highest mean yield of 127.6 nuts palm-1 year-1 and was on par with ECT x GBGD (106.9 nuts palm-1 year-1), COD x LCT (108.0 nuts palm-1 year-1) and WCT x MYD (107.6 nuts palm-1 year-1). Hybrid GBGD x PHOT recorded the highest fruit length (23.9 cm) followed by ECT x GBGD (23.3 cm). The hybrid ECT x GBGD recorded the highest values for most of the fruit characteristics viz., fruit breadth (17.3 cm), fruit weight (1180.0 g), husked fruit weight (758.0 g) and copra weight (231.1 g). The variety ‘Laccadive Ordinary’ recorded higher oil content (71.1%) compared to its hybrids, LCT x GBGD (70.8%), COD x LCT (70.0%) and LCT x COD (69.8%). Hybrids displayed substantial differences in their heterotic response for nut characters. The highest yielding hybrid, GBGD x ECT excelled its standard check by 40.8 per cent followed by LCT x COD (39.4%)

Early evaluation of cocoa (Theobroma cacao L.) clones as intercrop in coconut gardens under red river region of Assam State, India

A field experiment was conducted at Horticultural Research Station (AICRP on Palms), Kahikuchi of Assam Agricultural University for three consecutive years (2018-20) to study the initial performance of cocoa clones as intercrop in adult coconut (Cocos nucifera L) garden spaced at 7.5 m × 7.5 m taking sixteen cocoa clones. Data on tree height, stem girth, number of pods, pod weight, number of beans pod-1, dry bean weight tree-1 year-1 and single dry bean weight revealed significant variations among the 16 cocoa clones. Dried beans are the prime economic produce of cocoa, and single dry bean weight ranged from 0.95 to 1.4 g. With respect to dry bean yield tree-1, VTLC-20 recorded a significantly higher dry bean yield of 2.2 kg tree-1 followed by VTLC-18 (1.5 kg tree-1) compared to other cocoa clones, and eight clones yielded more than 1.0 kg dry bean tree-1. Results showed that the number of leaves on the crown, number of inflorescences per palm and nut yield of coconut was not negatively affected; rather, there was an increase in the yield of coconut over a period

Spatio-temporal expression patterns of Arabidopsis thaliana and Medicago truncatula defensin-like genes

Plant genomes contain several hundred defensin-like (DEFL) genes that encode short cysteine-rich proteins resembling defensins, which are well known antimicrobial polypeptides. Little is known about the expression patterns or functions of many DEFLs because most were discovered recently and hence are not well represented on standard microarrays. We designed a custom Affymetrix chip consisting of probe sets for 317 and 684 DEFLs from Arabidopsis thaliana and Medicago truncatula, respectively for cataloging DEFL expression in a variety of plant organs at different developmental stages and during symbiotic and pathogenic associations. The microarray analysis provided evidence for the transcription of 71% and 90% of the DEFLs identified in Arabidopsis and Medicago, respectively, including many of the recently annotated DEFL genes that previously lacked expression information. Both model plants contain a subset of DEFLs specifically expressed in seeds or fruits. A few DEFLs, including some plant defensins, were significantly up-regulated in Arabidopsis leaves inoculated with Alternaria brassicicola or Pseudomonas syringae pathogens. Among these, some were dependent on jasmonic acid signaling or were associated with specific types of immune responses. There were notable differences in DEFL gene expression patterns between Arabidopsis and Medicago, as the majority of Arabidopsis DEFLs were expressed in inflorescences, while only a few exhibited root-enhanced expression. By contrast, Medicago DEFLs were most prominently expressed in nitrogen-fixing root nodules. Thus, our data document salient differences in DEFL temporal and spatial expression between Arabidopsis and Medicago, suggesting distinct signaling routes and distinct roles for these proteins in the two plant species

Melamine formaldehyde-metal organic gel interpenetrating polymer network derived intrinsic Fe-N-doped porous graphitic carbon electrocatalysts for oxygen reduction reaction

Fe, N doped porous graphitic carbon electrocatalyst (Fe-MOG-MF-C), obtained by pyrolysis of an Interpenetrating Polymer Network (IPN) comprised of melamine formaldehyde (MF as hard segment) and Metal-Organic Gel (MOG as soft segment), exhibited significant Oxygen Reduction Reaction (ORR) activity in alkaline medium. BET surface area analysis of Fe-MOG-MF-C showed high surface area (821 m2 g-1), while TEM, Raman and XPS results confirmed Fe and N co-doping. Furthermore, a modulated porous morphology with a higher degree of surface area (950 m2 g-1) has been accomplished for the system (Fe-MOG-MFN-C) when aided by a sublimable porogen, such as naphthalene. XPS results further demonstrated that these systems exhibited a better degree of distribution of graphitic N and an onset potential value of 0.91 V vs. RHE in 0.1 M KOH solution following an efficient four-electron ORR pathway. The electrocatalytic activity of Fe-MOG-MFN-C is superior to that of Fe-MOG-MF-C by virtue of its higher graphitic N content and surface area. Thus, the study presents a new class of IPN derived MF-MOG nanocomposites with the potential to generate extended versions of in situ Fe-N doped porous graphitic carbon structures with superior ORR activity