Pharmacologic management of overactive bladder

Overactive bladder (OAB) is a prevalent and costly condition that can affect any age group. Typical symptoms include urinary urgency, frequency, incontinence and nocturia. OAB occurs as a result of abnormal contractions of the bladder detrusor muscle caused by the stimulation of certain muscarinic receptors. Therefore, antimuscarinic agents have long been considered the mainstay of pharmacologic treatment for OAB. Currently, there are five such agents approved for the management of OAB in the United States: oxybutynin, tolterodine, trospium, solifenacin and darifenacin. This article summarizes the efficacy, contraindications, precautions, dosing and common side effects of these agents. All available clinical trials on trospium, solifenacin and darifenacin were reviewed to determine its place in therapy

Philanthropic Foundations In Asia: Insights from Singapore, Myanmar and China

This study looks at an emerging trend in which wealthy families, individuals, and corporations in Asia set up foundations to institutionalise their giving. This giving is motivated by a myriad of factors beyond prestige and status, including the desire to give back to society, religion, family and personal values, the desire to drive change, personal experience, and/or affiliations.This study finds that philanthropic foundations in Asia can be characterised by their operational model, governance structure, and philanthropic focus. In emerging economies in Asia like Myanmar and China, these foundations tend to give nationally and operate their own programmes. On the other hand, foundations in developed economies like Singapore and Hong Kong tend to give both regionally and nationally via grants to civil society organisations that operate programmes, as opposed to running programmes themselves. Further, families tend to retain significant control of foundations in Singapore and Hong Kong, while programme funding serves as the preferred funding mode.This study also discusses the various challenges and opportunities faced by the nascent philanthropic sector in Asia that can address some of the developmental and structural gaps left by the public, private, and people sectors.

Effect of linguistic context on metaphor comprehension in Cantonese-speaking children

Thesis (B.Sc)--University of Hong Kong, 2009."A dissertation submitted in partial fulfilment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, June 30, 2009."Includes bibliographical references (p. 28-30).published_or_final_versionSpeech and Hearing SciencesBachelorBachelor of Science in Speech and Hearing Science

Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole

Delusions, hallucinations and other psychotic symptoms can accompany a number of conditions in late life. As such, elderly patients are commonly prescribed antipsychotic medications for the treatment of psychosis in both acute and chronic conditions. Those conditions include schizophrenia, bipolar disorder, depression and dementia. Elderly patients are at an increased risk of adverse events from antipsychotic medications because of age-related pharmacodynamic and pharmacokinetic changes as well as polypharmacy. Drug selection should be individualized to the patient’s previous history of antipsychotic use, current medical conditions, potential drug interactions, and potential side effects of the antipsychotic. Specifically, metabolic side effects should be closely monitored in this population. This paper provides a review of aripiprazole, a newer second generation antipsychotic agent, for its use in a variety of psychiatric disorders in the elderly including schizophrenia, bipolar disorder, dementia, Parkinson’s disease and depression. We will review the pharmacokinetics and pharmacodynamics of aripiprazole as well as dosing, diagnostic indications, efficacy studies, and tolerability including its metabolic profile. We will also detail patient focused perspectives including quality of life, patient satisfaction and adherence

The Synthesis-Enabled Stereochemical Elucidation of the Marine Natural Products Hemicalide and Phormidolide A

The structural complexity and biological activity of marine natural products have made them attractive targets for synthetic chemists. In cases where their relative and/or absolute configuration is unknown, total synthesis becomes a powerful method to enable their structural elucidation, as highlighted in Part I. This thesis discusses synthetic efforts towards two marine natural products, hemicalide (1) and phormidolide A (2), with the end goal of establishing and/or confirming the compound’s full stereochemistry. Hemicalide’s low isolation yield from its marine sponge source meant that none of the 21 stereocenters were assigned in the original patent literature. Previous computational and synthetic work by Ardisson and Cossy, as well as the Paterson and Goodman groups, have narrowed down the possibilities for the C1-C15, C16-C25 and C35-C46 fragments to a single diastereomer with reasonable confidence. However, the relative configuration between fragments and the absolute stereochemistry remains unknown. Part II describes the synthesis of the C16-C28 dihydroxylactone fragment, which was used to successfully assemble a diastereomer of the C1-C28 truncate. Comparisons with the alternative configuration synthesised by Han enabled the definitive assignment of the relative configuration between the C1-C15 and the C16-C25 region of hemicalide. These studies also illuminated the nature of the C1 carboxyl group in the natural product. Phormidolide A possesses several fascinating structural motifs. Its terminal bromomethoxydiene (BMD) motif in particular, is unprecedented among natural products. Furthermore, inconclusive stereochemical evidence presented in the literature meant that a synthesis-guided stereochemical evaluation is required. Part III discusses synthetic efforts to the natural product, involving the expedient synthesis of the C18-C23 vinyl iodide and the C25-C33 side chain bearing the unique BMD motif. Towards the end goal of a total synthesis, this chapter also illustrates the evolution of the fragment coupling strategy, which led to the reassignment of seven of the 11 stereocentres present in phormidolide A.I thank the Woolf Fisher Trust and the Krishnan-Ang Scholarship for their generous financial support

Can Corporate Social Responsibility Fill Institutional Voids?

We conduct empirical analysis on the relation between firm value and corporate social responsibility (CSR) using 134,823 observations of 2542 firms across 44 countries from 2009 to 2014. We find that the firm value is positively related to the overall CSR score of the firm. At a more granular level, we find that good environmental score is positively related to the firm value and good social and governance scores are negatively related to the firm value. Since these firms operate in different institutional frameworks, we explore whether the institutional voids—the absence of institutions or intermediaries that are instrumental in supporting business operations in a country—may result in greater firm valuation for its CSR and vice versa. Our results show that firms’ environmental scores and social scores receive higher valuation in countries with weaker institutions. Overall, our findings suggest that CSR creates value for firms by filling institutional voids in their home country

A yeast's eye view of mammalian reproduction: cross-species gene co-expression in meiotic prophase

<p>Abstract</p> <p>Background</p> <p>Meiotic prophase is a critical stage in sexual reproduction. Aberrant chromosome recombination during this stage is a leading cause of human miscarriages and birth defects. However, due to the experimental intractability of mammalian gonads, only a very limited number of meiotic genes have been characterized. Here we aim to identify novel meiotic genes important in human reproduction through computational mining of cross-species and cross-sex time-series expression data from budding yeast, mouse postnatal testis, mouse embryonic ovary, and human fetal ovary.</p> <p>Results</p> <p>Orthologous gene pairs were ranked by order statistics according to their co-expression profiles across species, allowing us to infer conserved meiotic genes despite obvious differences in cellular synchronicity and composition in organisms. We demonstrated that conserved co-expression networks could successfully recover known meiotic genes, including homologous recombination genes, chromatin cohesion genes, and genes regulating meiotic entry. We also showed that conserved co-expression pairs exhibit functional connections, as evidenced by the annotation similarity in Gene Ontology and overlap with physical interactions. More importantly, we predicted six new meiotic genes through their co-expression linkages with known meiotic genes, and subsequently used the genetically more amenable yeast system for experimental validation. The deletion mutants of all six genes showed sporulation defects, equivalent to a 100% validation rate.</p> <p>Conclusions</p> <p>We identified evolutionarily conserved gene modules in meiotic prophase by integrating cross-species and cross-sex expression profiles from budding yeast, mouse, and human. Our co-expression linkage analyses confirmed known meiotic genes and identified several novel genes that might be critical players in meiosis in multiple species. These results demonstrate that our approach is highly efficient to discover evolutionarily conserved novel meiotic genes, and yeast can serve as a valuable model system for investigating mammalian meiotic prophase.</p

Challenges of regulatory theory and practice : a study of hawker control in Hong Kong

published_or_final_versionPolitics and Public AdministrationMasterMaster of Public Administratio