Tramadol Potentiates Vasopressin Induced Analgesia in Albino Mice

The effect of centrally acting opioid analgesic Tramadol on vasopressin induced analgesia was evaluated in Swiss albino mice. Analgesia was evaluated in the mice using tail clip and writhing test techniques. Animals were divided into control and test groups (n=6).Arginine vasopressin (12 µg/kg i.p) and its synthetic analogue, Terlipressin (300 µg /kg i.v) injected in the mice produced analgesia by increasing the latency period by 131.6% and 53.5% respectively and reduced the acetic acid writhing by 45.85 % and 13.51 % respectively. Pretreatment with Tramadol (10 mg/kg i.p) potentiated the analgesic action of vasopressin and terlipressin  and increased the latency period and reduced the acetic acid induced writhings respectively. This study suggests that Tramadol can be combined with vasopressin for enhanced analgesic effect

Gut microbiome-based dietary intervention in Parkinson disease subject: A case report

A 54-year-old woman was seeking medical treatment for Parkinson disease (PD) in the neurology outpatient department in JSS Hospital, Mysore, India. She was challenged in terms of reduced mobility and had sought several treatment options to control her PD symptoms without successful outcome. After examination and confirmation of diagnosis, the decision was taken to design a precision nutritional intervention using a gut microbiome-based diet combined with medical treatment. After 2 months of a superfood dietary intervention, the patient showed signs of clinical improvement as evidenced by improved mobility and a change in the Hoehn and Yahr clinical severity scale from stages 3 to 2. In conclusion, it is possible to modulate the gut microbiome to reverse the established gut dysbiosis associated with the neurodegenerative process in PD, which can lead to clinical benefit by reducing functional disability