Getting Collaborative Networks Sustainable: Drivers and Barriers Within a Digital Laboratories Network

Part 1: Sustainable Collaborative NetworksInternational audienceRapid technology changesand the transition todigitalisedproduction and educationpose significant challenges toengineeringeducation. Hands-onexperimentation requiresaccess to new technologies, often in a labsetting. Cross-organisationalcollaboration and resource sharing can reduce costs and increase utilisation. Success depends on trust, practicalresourcemanagement, smooth service delivery,and performance. This paper presentsan initial evaluation of a resourcemanagement approach using an online labbooking process,considering stakeholders'various roles and needs. In addition, we gathered external inputsthrough twosurveys targeting industry and students as potential customersandinterviews with professionals working in collaborative working environments to assess drivers and barriers to network success using SCORmetrics. These findings are essentialinputs for lower-level design decisions, such as designingtheunderlying business models, the relationship betweeneducation and research for the labs, the rules of use, and how to motivate collaborators

Cybersecurity Comparison of Brain-Based Automotive Electrical and Electronic Architectures

Modern autonomous vehicles with an electric/electronic (E/E) architecture represent the next big step in the automation and evolution of smart and self-driving vehicles. This technology is of significant interest nowadays and humans are currently witnessing the development of the different levels of automation for their vehicles. According to recent demand, the components of smart vehicles are centrally or zonally connected, as well as connected to clouds to ensure the seamless automation of driving functions. This necessity has a downside, as it makes the system vulnerable to malicious attacks from hackers with unethical motives. To ensure the control, safety, and security of smart vehicles, attaining and upholding automotive cybersecurity standards is inevitable. The ISO/SAE 21434 Road vehicle—Cybersecurity engineering standard document was published in 2021 and can be considered the Bible of automotive cybersecurity. In this paper, a comparison between four different E/E architectures was made based on the aforementioned standard. One of them is the traditional distributed architecture with many electronic control units (ECUs). The other three architectures consist of centralized or zonally distributed high-performance computers (HPCs). As the complexity of autonomous E/E systems are on the rise, the traditional distributive method is compared against the HPC (brain)-based architectures to visualize a comparative scenario between the architectures. The authors of this paper analyzed the threats and damage scenarios of the architectures using the ISO/SAE 21434 standard, “Microsoft Threat Analysis Tool - STRIDE”, TARA, and “Ansys Medini Analyze”. Security controls are recommended to mitigate the threats and risks in all of these studied architectures. This work attempted to mitigate the gap in the scholarly literature by creating a comparative image of the E/E architectures on a generalized level. The exploratory method of this research provides the reader with knowledge on four different architecture types, their fundamental properties, advantages, and disadvantages along with a general overview of the threats and vulnerabilities associated with each in light of the ISO/SAE 21434 standard. The improvement possibilities of the studied architectures are provided and their advantages and disadvantages are highlighted herein

Cybersecurity Comparison of Brain-Based Automotive Electrical and Electronic Architectures

Modern autonomous vehicles with an electric/electronic (E/E) architecture represent the next big step in the automation and evolution of smart and self-driving vehicles. This technology is of significant interest nowadays and humans are currently witnessing the development of the different levels of automation for their vehicles. According to recent demand, the components of smart vehicles are centrally or zonally connected, as well as connected to clouds to ensure the seamless automation of driving functions. This necessity has a downside, as it makes the system vulnerable to malicious attacks from hackers with unethical motives. To ensure the control, safety, and security of smart vehicles, attaining and upholding automotive cybersecurity standards is inevitable. The ISO/SAE 21434 Road vehicle—Cybersecurity engineering standard document was published in 2021 and can be considered the Bible of automotive cybersecurity. In this paper, a comparison between four different E/E architectures was made based on the aforementioned standard. One of them is the traditional distributed architecture with many electronic control units (ECUs). The other three architectures consist of centralized or zonally distributed high-performance computers (HPCs). As the complexity of autonomous E/E systems are on the rise, the traditional distributive method is compared against the HPC (brain)-based architectures to visualize a comparative scenario between the architectures. The authors of this paper analyzed the threats and damage scenarios of the architectures using the ISO/SAE 21434 standard, “Microsoft Threat Analysis Tool - STRIDE”, TARA, and “Ansys Medini Analyze”. Security controls are recommended to mitigate the threats and risks in all of these studied architectures. This work attempted to mitigate the gap in the scholarly literature by creating a comparative image of the E/E architectures on a generalized level. The exploratory method of this research provides the reader with knowledge on four different architecture types, their fundamental properties, advantages, and disadvantages along with a general overview of the threats and vulnerabilities associated with each in light of the ISO/SAE 21434 standard. The improvement possibilities of the studied architectures are provided and their advantages and disadvantages are highlighted herein

Efficacy of the seven feature, fifteen point histological scoring system and CD56 in interpretation of liver biopsies in persistent neonatal cholestasis: A five-year study

Context: Neonatal cholestasis (NC) lasting more than 2 weeks affects one in 2500 live births. Extrahepatic biliary atresia (EHBA) and idiopathic neonatal hepatitis account for about 70% of all cases of NC. Differentiating these two conditions is important as patient management is very different for both the conditions. Aims: To assess the usefulness of the seven-feature, 15-point histological scoring system in the interpretation of liver biopsy in NC and usefulness of immunostaining with CD56 (N-CAM) in EHBA. Settings and Design: Retrospective study of 5 years′ duration at a pediatric referral institute, where the case load of NC is high and definitive surgery for EHBA is undertaken after histological confirmation. Materials and Methods: The study is of a 5-year duration conducted between June 2007 and May 2012. A total of 210 cases of NC were clinically diagnosed during this period. All the slides were reviewed with reference to a seven-feature, 15-point histological scoring system assessing its usefulness in the interpretation of liver biopsy in NC and utility of the immunohistochemical marker CD56 was also assessed as an aid in the characterization of bile ductular proliferation in EHBA. Statistical Analysis: Statistical analysis was performed and sensitivity and specificity of the histological scoring system for EHBA was analyzed. Results: Of the 210 liver biopsies reviewed using the scoring system, 122 cases were diagnosed as EHBA and 88 cases were diagnosed as other causes of NC. The overall sensitivity of this scoring system was 95.5%, specificity was 93.1% and diagnostic accuracy was 94.6%. Conclusions: The seven-feature, 15-point histological scoring system has good diagnostic accuracy in the interpretation of liver histology in NC as advanced histopathological findings even at younger age require immediate surgery. CD-56 is a useful marker in the assessment of bile ductular proliferation in EHBA

Serious games as a means to promote thinking about European identity:a case study of the design and development of the RU EU? game

The diversity of the EU is both a strength and a weakness, with Issues of National and European identity contributing to division, marginalization and exclusion. Many European citizens have very firmly entrenched, but frequently simplistic, views about the value of the European Union as good (pro EU) or bad (anti EU). To promote a culture of increased tolerance and inclusion, EU citizens need to develop a more mature and nuanced understanding of National and European identity that considers the validity of others’ points of view. Serious Games are increasingly recognised as active and effective methods for tackling complex social problems. Therefore, the RU EU? (are you EU?) project developed a game to increase players’ awareness of the complexity of European identity and values, to help players develop a more detailed understanding of European identity and promote critical thinking about their own views, the views of others, and the wider societal consequences. In this paper we describe the RU EU? Game as a case study explaining the thinking behind the game design. We outline the early design tasks that led to development of the multicomponent model of European identity that we used in the game, the adoption of the journalist narrative and the tools that assisted the player in his goal of compiling and publishing a set of articles about European identity. We discuss the potential of the game tools and mechanics to be used more widely to promote social understanding and inclusion

What’s In a game?:A game-based approach to exploring 21st-century European identity and values

This article focuses on the early stages of an international project on gamifying national identity. It examines the production of the content required for developing a sophisticated and engaging approach to pedagogical innovation in education, through game- based learning. This will encourage individuals to think about both European and national identity, specifically within the context of the European Union (EU). At a time when the EU faces significant challenges, a better understanding and appreciation of the role of national and supra-national identity and belonging in Europe is clear. RU EU?–an Erasmus+ funded project–aims to develop an innovative online game to help students and others enhance their understanding of their own national and European identities and challenge attitudes and prejudices. The content development of the game has brought together experts with socio-political knowledge, pedagogical understanding and technical expertise. This article discusses the early stages in the content development process, during which we amassed material from literature reviews, academic interviews and student focus groups and surveys. We sought to ensure that the content of the game reflected the issues raised within the game development lifecycle and our article describes our engagement with this material and its integration into game content

Trimer IgG and neutralising antibody response to COVID-19 mRNA vaccination in individuals with sarcoidosis

Background Individuals with sarcoidosis are at higher risk for infection owing to underlying disease pathogenesis and need for immunosuppressive treatment. Current knowledge as to how subjects with sarcoidosis respond to different forms of vaccination is limited. We examined quantitative and functional antibody response to COVID-19 vaccination in infection-naive subjects with and without sarcoidosis. Methods Our prospective cohort study recruited 14 subjects with biopsy-proven sarcoidosis and 27 age–sex matched controls who underwent a two-shot series of the BNT162b2 mRNA vaccine at the University of Illinois at Chicago. Baseline, 4-week and 6-month trimer spike protein IgG and neutralising antibody (nAb) titres were assessed. Correlation and multivariate regression analysis was conducted. Results Sarcoidosis subjects had a significant increase in short-term antibody production to a level comparable to controls; however, IgG titres significantly declined back to baseline levels by 6 months. Corresponding neutralising assays revealed robust nAb titres in sarcoidosis subjects that persisted at 6 months. A significant and strong correlation between IgG and nAb titres across all time points was observed in the control group. However within the sarcoidosis group, a significant but weak correlation between antibody levels was found. Overall, IgG levels were poor predictors of nAb titres at short- or long-term time points. Conclusions Sarcoidosis subjects exhibit nAb induced by the BNT162b2 mRNA SARS-CoV-2 vaccine at levels comparable to controls that persists at 6 months indicating conferred immunity. Trimer IgG levels are poor predictors of nAb in subjects with sarcoidosis. Studies of further antibody immunoglobulins and subtypes warrant investigation