Depression and Anxiety in the Elderly: Translating Clinical Methods for Use by Non-Professionals

Because seniors suffer depression and anxiety and professional help is not always available, a simple structure is proposed for non-professionals to provide effective help to seniors. These potential helpers who are present in the seniors’ daily environments can then assist the seniors in adjusting to their stage of life and avoid the distress arising from loneliness, purposelessness and physical/mental decline, the factors accounting for the bulk of seniors’ problems. The few therapeutic skills these willing helpers need are described and embedded in a sequence of procedural steps they can use. Mental health professionals are encouraged to teach these skills at every opportunity

Filtrations on the knot contact homology of transverse knots

We construct a new invariant of transverse links in the standard contact structure on R^3. This invariant is a doubly filtered version of the knot contact homology differential graded algebra (DGA) of the link. Here the knot contact homology of a link in R^3 is the Legendrian contact homology DGA of its conormal lift into the unit cotangent bundle S^*R^3 of R^3, and the filtrations are constructed by counting intersections of the holomorphic disks of the DGA differential with two conormal lifts of the contact structure. We also present a combinatorial formula for the filtered DGA in terms of braid representatives of transverse links and apply it to show that the new invariant is independent of previously known invariants of transverse links.Comment: 23 pages, v2: minor corrections suggested by refere

Logarithmic asymptotics for the supremum of a stochastic process

Logarithmic asymptotics are proved for the tail of the supremum of a stochastic process, under the assumption that the process satisfies a restricted large deviation principle on regularly varying scales. The formula for the rate of decay of the tail of the supremum, in terms of the underlying rate function, agrees with that stated by Duffield and O’Connell [Math. Proc. Cambridge Philos. Soc. (1995) 118 363–374]. The rate function of the process is not assumed to be convex. A number of queueing examples are presented which include applications to Gaussian processes and Weibull sojourn sources

Characterizing the Vertical Processes of Ozone in Colorado's Front Range Using the GSFC Ozone Dial

Although characterizing the interactions of ozone throughout the entire troposphere are important for health and climate processes, there is a lack of routine measurements of vertical profiles within the United States. In order to monitor this lower ozone more effectively, the National Aeronautics and Space Administration (NASA) Goddard Space Flight Center TROPospheric OZone DIfferential Absorption Lidar (GSFC TROPOZDIAL) has been developed and validated within the Tropospheric Ozone Lidar Network (TOLNet). Two scientifically interesting ozone episodes are presented that were observed during the 2014 Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER AQ) campaign at Ft. Collins,Colorado.The first case study, occurring between 22-23 July 2014, indicates enhanced concentrations of ozone at Ft. Collins during nighttime hours, which was due to the complex recirculation of ozone within the foothills of the Rocky Mountain region. Although quantifying the ozone increase a loft during recirculation episodes has been historically difficult, results indicate that an increase of 20 -30 ppbv of ozone at the Ft. Collins site has been attributed to this recirculation. The second case, occurring between Aug 4-8th 2014, characterizes a dynamical exchange of ozone between the stratosphere and the troposphere. This case, along with seasonal model parameters from previous years, is used to estimate the stratospheric contribution to the Rocky Mountain region. Results suggest that a large amount of stratospheric air is residing in the troposphere in the summertime near Ft. Collins, CO. The results also indicate that warmer tropopauses are correlated with an increase in stratospheric air below the tropopause in the Rocky Mountain Region

Exoplanet Catalogues

One of the most exciting developments in the field of exoplanets has been the progression from 'stamp-collecting' to demography, from discovery to characterisation, from exoplanets to comparative exoplanetology. There is an exhilaration when a prediction is confirmed, a trend is observed, or a new population appears. This transition has been driven by the rise in the sheer number of known exoplanets, which has been rising exponentially for two decades (Mamajek 2016). However, the careful collection, scrutiny and organisation of these exoplanets is necessary for drawing robust, scientific conclusions that are sensitive to the biases and caveats that have gone into their discovery. The purpose of this chapter is to discuss and demonstrate important considerations to keep in mind when examining or constructing a catalogue of exoplanets. First, we introduce the value of exoplanetary catalogues. There are a handful of large, online databases that aggregate the available exoplanet literature and render it digestible and navigable - an ever more complex task with the growing number and diversity of exoplanet discoveries. We compare and contrast three of the most up-to-date general catalogues, including the data and tools that are available. We then describe exoplanet catalogues that were constructed to address specific science questions or exoplanet discovery space. Although we do not attempt to list or summarise all the published lists of exoplanets in the literature in this chapter, we explore the case study of the NASA Kepler mission planet catalogues in some detail. Finally, we lay out some of the best practices to adopt when constructing or utilising an exoplanet catalogue.Comment: 14 pages, 6 figures. Invited review chapter, to appear in "Handbook of Exoplanets", edited by H.J. Deeg and J.A. Belmonte, section editor N. Batalh

Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide

In view of the call by the World Health Organization (WHO) for elimination of schistosomiasis as a public health problem by 2025, use of molluscicides in snail control to supplement chemotherapy–based control efforts is likely to increase in the coming years. The mechanisms of action of niclosamide, the active ingredient in the most widely used molluscicides, remain largely unknown. A better understanding of its toxicology at the molecular level will both improve our knowledge of snail biology and may offer valuable insights into the development of better chemical control methods for snails. We used a recently developed Biomphalaria glabrata oligonucleotide microarray (31K features) to investigate the effect of sublethal exposure to niclosamide on the transcriptional responses of the snail B. glabrata relative to untreated snails. Most of the genes highly upregulated following exposure of snails to niclosamide are involved in biotransformation of xenobiotics, including genes encoding cytochrome P450s (CYP), glutathione S-transferases (GST), and drug transporters, notably multi-drug resistance protein (efflux transporter) and solute linked carrier (influx transporter). Niclosamide also induced stress responses. Specifically, six heat shock protein (HSP) genes from three super-families (HSP20, HSP40 and HSP70) were upregulated. Genes encoding ADP-ribosylation factor (ARF), cAMP response element-binding protein (CREB) and coatomer, all of which are involved in vesicle trafficking in the Golgi of mammalian cells, were also upregulated. Lastly, a hemoglobin gene was downregulated, suggesting niclosamide may affect oxygen transport. Our results show that snails mount substantial responses to sublethal concentrations of niclosamide, at least some of which appear to be protective. The topic of how niclosamide’s lethality at higher concentrations is determined requires further study. Given that niclosamide has also been used as an anthelmintic drug for decades and has been found to have activity against several types of cancer, our findings may be of relevance in understanding how both parasites and neoplastic cells respond to this compound

Preliminary Report on a Spiritually-Based PTSD Intervention for Military Veterans

Military veterans can experience spiritual/religious struggles such as weakening of beliefs, loss of meaning, increased guilt, difficulty forgiving, and moral challenges as a result of military trauma. While mainstream treatments (e.g., exposure therapy) have been shown to be effective for many, they often fail to address these issues adequately. This paper describes an 8-session spiritually-based group intervention designed to treat trauma-related spiritual wounds among military veterans. A program evaluation conducted with 24 veterans revealed significant reductions in PTSD symptoms, spiritual injury, and negative religious coping from pretest to posttest. The findings support the need for additional PTSD treatment approaches

Lidar Validation Measurements at the NOAA Mauna Loa Observatory NDACC Station

NASA's Goddard Space Flight Center (GSFC) transported two lidar instruments to the NOAA facility at the Mauna Loa Observatory (MLO) on the Big Island of Hawaii, to participate in an official, extended validation campaign. This site is situated 11,141 ft. above sea level on the side of the mountain. The observatory has been making atmospheric measurements regularly since the 1950's, and has hosted the GSFC Stratospheric Ozone (STROZ) Lidar and the GSFC Aerosol and Temperature (AT) Lidar on several occasions, most recently between November, 2012 and November, 2015. The purpose of this extended deployment was to participate in Network for the Detection of Atmospheric Composition Change (NDACC) Validation campaigns with the JPL Stratospheric Ozone Lidar and the NOAA Temperature, Aerosol and Water Vapor instruments as part of the routine NDACC Validation Protocol