5 research outputs found
ΠΠΎΠ»ΠΎΡΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅Π½ΡΠΎΡΡ Π½Π° Π³Π΅ΠΏΠ°ΡΠΈΠ½ Ρ ΠΊΡΠ°ΡΠΈΡΠ΅Π»ΡΠΌΠΈ ΡΠΎΠ»ΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΡΠΉ ΡΠΈΠ½ΠΈΠΉ ΠΈ ΠΌΠ°Π»Π°Ρ ΠΈΡΠΎΠ²ΡΠΉ Π·Π΅Π»Π΅Π½ΡΠΉ
ΠΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³ Π³Π΅ΠΏΠ°ΡΠΈΠ½Π° Π² ΠΊΡΠΎΠ²ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π΄ΠΎΠ·ΠΈΡΠΎΠ²ΠΊΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΈ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ Π°Π½ΡΠΈΠΊΠΎΠ°Π³ΡΠ»ΡΠ½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΡΠΈ ΠΊΡΡΡΠΎΠ²ΠΎΠΌ ΠΏΡΠΈΡΠΌΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
Π³Π΅ΠΏΠ°ΡΠΈΠ½, ΡΠΎΠΏΡΡΠΆΠ΅Π½Π½ΡΡ
Ρ ΡΠΈΡΠΊΠΎΠΌ ΠΊΡΠΎΠ²ΠΎΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΈ ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡΡ ΠΏΠ΅ΡΠ΅Π΄ΠΎΠ·ΠΈΡΠΎΠ²ΠΊΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΡΠ΅ΡΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠΉ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΈ ΡΠ»Π°Π±ΠΎΠΉ ΠΈ ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠΉ ΠΏΠΎΡΠ΅ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ , ΠΏΡΠΈ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ ΠΌΠ°ΡΡΠ΅ ΡΠ΅Π»Π° ΠΈΠ»ΠΈ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠΈ, ΠΏΡΠΈ ΠΊΡΠΎΠ²ΠΎΡΠ΅ΡΠ΅Π½ΠΈΡΡ
Π½Π΅ΡΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½Π΅Π·Π°. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Π° ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΡΠΎΡΠ±ΡΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠΎΡΠΌ ΡΠΎΠ»ΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΈΠ½Π΅Π³ΠΎ ΠΈ ΠΌΠ°Π»Π°Ρ
ΠΈΡΠΎΠ²ΠΎΠ³ΠΎ Π·Π΅Π»Π΅Π½ΠΎΠ³ΠΎ, ΡΠΎΡΠ±ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π½Π° ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°ΠΊΡΠΈΠ»Π°ΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΠΈΡΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ° ΠΏΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π³Π΅ΠΏΠ°ΡΠΈΠ½Π° Π² ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ
. Π§ΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ½ΡΠΉ ΡΠ»Π΅ΠΌΠ΅Π½Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³Π΅ΠΏΠ°ΡΠΈΠ½Π° Π² ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ
Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΠΌΠΈ 50-210 ΠΌΠ³/Π». ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΊΡΠ°ΡΠΈΡΠ΅Π»Ρ ΠΏΡΠΎΠΏΠΎΡΡΠΈΠΎΠ½Π°Π»ΡΠ½Ρ Π·Π½Π°ΡΠ΅Π½ΠΈΡΠΌ ΠΈΡ
ΠΌΠΎΠ»ΡΡΠ½ΡΡ
ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½ΠΈΡ Π² Π²ΠΎΠ΄Π½ΡΡ
ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ
. ΠΡΠ΅Π΄Π΅Π»Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½Ρ Π½Π° ΠΏΠΎΡΡΠ΄ΠΎΠΊ ΠΏΡΠΈ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ ΠΎΠ±ΡΠ΅ΠΌΠ° ΡΠ°ΡΡΠ²ΠΎΡΠ° Π½Π° ΡΡΠ°Π΄ΠΈΠΈ ΡΠΎΡΠ±ΡΠΈΠΈ ΠΈ, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΎΠ±ΡΠ΅ΠΌΠ° ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ°. ΠΡΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
ΡΠ²ΡΡΠ΅ 10-5 ΠΌΠΎΠ»Ρ/Π» Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ Π²ΠΈΠ·ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ»ΡΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π΄Π΅ΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π΅ΠΏΠ°ΡΠΈΠ½Π° Π² ΡΠ°ΡΡΠ²ΠΎΡΠ΅ ΠΏΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΈ ΠΈΡΡΠ΅Π·Π½ΠΎΠ²Π΅Π½ΠΈΡ ΠΎΠΊΡΠ°ΡΠΊΠΈ ΠΊΡΠ°ΡΠΈΡΠ΅Π»Ρ Π² ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΠΈΡΠ΅
EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGES
Aim. To evaluate a short-term efficacy and safety of nebivolol and carvedilol in hypertensive patients of different ages in acute pharmacological test (APT).Material and methods. 119 patients with arterial hypertension (HT) 2-3 degrees aged 33-89 y.o. were involved into the study. Patients were split into 2 groups according to age: young and middle-aged patients (30-59 y.o.); elderly and senile patients (β₯60 y.o.). All patients were randomized for carvedilol (12.5 mg once daily) or nebivolol (5 mg once daily) therapy after wash-out period (3-10 days). Ambulatory blood pressure monitoring (ABPM) was performed one day before and one day after first drug taking and ABPM indices were compared.Results. APT with carvedilol and nebivolol in patients of young and middle age showed significant antihypertensive effect on systolic (-6.9 and -6.0 mm Hg, resp.), diastolic (- 4.6 and -4.7 mm Hg, resp.) and pulse (-1.7 and -1.4 mm Hg, resp.) blood pressure (BP). In patients of elderly and senile age the first daily dose of nebivolol did not have influence on systolic and pulse BP (-2.73 and +0.50 mm Hg, resp., p>0.05), unlike carvedilol (-5.27 and -1.43 mm Hg, resp. p<0.05). Carvedilol and nebivolol increased of hypotension time index for diastolic BP in younger (7,6 and 7,7%, resp.) and elder (11 and 8,2% resp.) patients.Conclusion. Carvedilol in initial dose reduces systolic and pulse BP more significantly than nebivolol does in hypertensive elderly and senile patients. Increase of hypotension time index for diastolic BP revealed for both drugs can limit their use in patients with initially low diastolic BP
EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGES
Aim. To evaluate a short-term efficacy and safety of nebivolol and carvedilol in hypertensive patients of different ages in acute pharmacological test (APT).Material and methods. 119 patients with arterial hypertension (HT) 2-3 degrees aged 33-89 y.o. were involved into the study. Patients were split into 2 groups according to age: young and middle-aged patients (30-59 y.o.); elderly and senile patients (β₯60 y.o.). All patients were randomized for carvedilol (12.5 mg once daily) or nebivolol (5 mg once daily) therapy after wash-out period (3-10 days). Ambulatory blood pressure monitoring (ABPM) was performed one day before and one day after first drug taking and ABPM indices were compared.Results. APT with carvedilol and nebivolol in patients of young and middle age showed significant antihypertensive effect on systolic (-6.9 and -6.0 mm Hg, resp.), diastolic (- 4.6 and -4.7 mm Hg, resp.) and pulse (-1.7 and -1.4 mm Hg, resp.) blood pressure (BP). In patients of elderly and senile age the first daily dose of nebivolol did not have influence on systolic and pulse BP (-2.73 and +0.50 mm Hg, resp., p>0.05), unlike carvedilol (-5.27 and -1.43 mm Hg, resp. p<0.05). Carvedilol and nebivolol increased of hypotension time index for diastolic BP in younger (7,6 and 7,7%, resp.) and elder (11 and 8,2% resp.) patients.Conclusion. Carvedilol in initial dose reduces systolic and pulse BP more significantly than nebivolol does in hypertensive elderly and senile patients. Increase of hypotension time index for diastolic BP revealed for both drugs can limit their use in patients with initially low diastolic BP.</p