Dichloro-<i>bis</i>-(pyridine-2-yl-undecyl-amine)zinc(II), [ZnCl₂(C₁₆N₂H₂₆)₂]: Synthesis, characterization and antimalarial activity

<p>A nitrogen-based ligand (pyridine-2-yl-undecyl-amine) (<b>1</b>) was synthesized and used for the synthesis of a Zn(II) compound (dichloro-bis(pyridine-2-yl-undecyl-amine)zinc(II)) (<b>2</b>). Compound <b>2</b> was synthesized and characterized using IR, ¹H NMR, and ¹³C{¹H} NMR spectroscopy. The crystal structure of <b>2</b> was determined using single-crystal X-ray crystallography. The compound was tested for its anti-malarial activity using two methods, a semi-quantitative micro-assay and a previously self-developed quantitative <i>in vitro</i> method. Both methods were used to study the efficiency of <b>2</b> to inhibit the formation of the malaria pigment considered an important target of many anti-malarial drugs such as chloroquine and amodaquine. The efficiency of <b>2</b> to prevent the formation of β-hematin was 71.4%. The efficiency of amodiaquine as a standard drug was reported at 93.8%.</p