Observation and interpretation of motional sideband asymmetry in a quantum electro-mechanical device

Quantum electro-mechanical systems offer a unique opportunity to probe quantum noise properties in macroscopic devices, properties which ultimately stem from the Heisenberg Uncertainty Principle. A simple example of this is expected to occur in a microwave parametric transducer, where mechanical motion generates motional sidebands corresponding to the up and down frequency-conversion of microwave photons. Due to quantum vacuum noise, the rates of these processes are expected to be unequal. We measure this fundamental imbalance in a microwave transducer coupled to a radio-frequency mechanical mode, cooled near the ground state of motion. We also discuss the subtle origin of this imbalance: depending on the measurement scheme, the imbalance is most naturally attributed to the quantum fluctuations of either the mechanical mode or of the electromagnetic field

Mechanically Detecting and Avoiding the Quantum Fluctuations of a Microwave Field

During the theoretical investigation of the ultimate sensitivity of gravitational wave detectors through the 1970's and '80's, it was debated whether quantum fluctuations of the light field used for detection, also known as photon shot noise, would ultimately produce a force noise which would disturb the detector and limit the sensitivity. Carlton Caves famously answered this question with "They do." With this understanding came ideas how to avoid this limitation by giving up complete knowledge of the detector's motion. In these back-action evading (BAE) or quantum non-demolition (QND) schemes, one manipulates the required quantum measurement back-action by placing it into a component of the motion which is unobserved and dynamically isolated. Using a superconducting, electro-mechanical device, we realize a sensitive measurement of a single motional quadrature with imprecision below the zero-point fluctuations of motion, detect both the classical and quantum measurement back-action, and demonstrate BAE avoiding the quantum back-action from the microwave photons by 9 dB. Further improvements of these techniques are expected to provide a practical route to manipulate and prepare a squeezed state of motion with mechanical fluctuations below the quantum zero-point level, which is of interest both fundamentally and for the detection of very weak forces

Quantum squeezing of motion in a mechanical resonator

As a result of the quantum, wave-like nature of the physical world, a harmonic oscillator can never be completely at rest. Even in the quantum ground state, its position will always have fluctuations, called the zero-point motion. Although the zero-point fluctuations are unavoidable, they can be manipulated. In this work, using microwave frequency radiation pressure, we both prepare a micron-scale mechanical system in a state near the quantum ground state and then manipulate its thermal fluctuations to produce a stationary, quadrature-squeezed state. We deduce that the variance of one motional quadrature is 0.80 times the zero-point level, or 1 dB of sub-zero-point squeezing. This work is relevant to the quantum engineering of states of matter at large length scales, the study of decoherence of large quantum systems, and for the realization of ultra-sensitive sensing of force and motion

Bremsstrahlung photon polarization for ee±→(eγ)e±ee^\pm\to (e\gamma)e^\pm, and ep→(eγ)pep\to (e\gamma)p high energy collisions

The polarization of bremsstrahlung photon in the processes $ee^\pm\to (e\gamma)e^\pm$, and $ep\to (e\gamma)p$ is calculated for peripheral kinematics, in the high energy limit where the cross section does not decrease with the incident energy. When the initial electron is unpolarized(longitudinally polarized) the final photon can be linearly (circularly) polarized. The Stokes parameters of the photon polarization are calculated as a function of the kinematical variables of process: the energy of recoil particle, the energy fraction of scattered electron, and the polar and azimuthal angles of photon. Numerical results are given in form of tables, for typical values of the relevant kinematic variables.Comment: 9 pages, 3 figure

Parameter identifiability and model selection for partial differential equation models of cell invasion

When employing a mechanistic model to study biological systems, practical parameter identifiability is important for making predictions in a wide range of scenarios, as well as for understanding the mechanisms driving the system behaviour. We argue that parameter identifiability should be considered alongside goodness-of-fit and model complexity as criteria for model selection. To demonstrate, we use a profile likelihood approach to investigate parameter identifiability for four extensions of the Fisher--KPP model, given experimental data from a cell invasion assay. We show that more complicated models tend to be less identifiable, with parameter estimates being more sensitive to subtle differences in experimental procedures, and require more data to be practically identifiable. The results from identifiability analysis can inform model selection, as well as data collection and experimental design.Comment: 23 pages in main text, 21 pages in supplementary material

Structural Study of Binary Phosphate Glasses by X-ray and Neutron Diffraction

X-ray and neutron diffraction study on the structure of five binary metaphosphate glasses has been made by applying the pair function method coupled with the interference function refining technique. The distances and coordination numbers for the pairs of P-O, O-O and M-O (M=Li, Na, Zn, Mg, and Ca) were determined and a fundamental local ordering unit structure in these binary phosphate glasses has been confirmed to be a PO_4 tetrahedron and the particular features have also been recognized with respect to the numbers of oxygens around magnesium and zinc cations

Interplay between carrier and impurity concentrations in annealed Ga1−x_{1-x}Mnx_{x}As intrinsic anomalous Hall Effect

Investigating the scaling behavior of annealed Ga$_{1-x}$Mn$_{x}$As anomalous Hall coefficients, we note a universal crossover regime where the scaling behavior changes from quadratic to linear, attributed to the anomalous Hall Effect intrinsic and extrinsic origins, respectively. Furthermore, measured anomalous Hall conductivities when properly scaled by carrier concentration remain constant, equal to theoretically predicated values, spanning nearly a decade in conductivity as well as over 100 K in T$_{C}$. Both the qualitative and quantitative agreement confirms the validity of new equations of motion including the Berry phase contributions as well as tunablility of the intrinsic anomalous Hall Effect.Comment: 4 pages, 5 figure

Cancer Tissue Engineering: A Novel 3D Polystyrene Scaffold for In Vitro Isolation and Amplification of Lymphoma Cancer Cells from Heterogeneous Cell Mixtures

Isolation and amplification of primary lymphoma cells in vitro setting is technically and biologically challenging task. To optimize culture environment and mimic in vivo conditions, lymphoma cell lines were used as a test case and were grown in 3-dimension (3D) using a novel 3D tissue culture polystyrene scaffold with neonatal stromal cells to represent a lymphoma microenvironment. In this model, the cell proliferation was enhanced more than 200-fold or 20,000% neoplastic surplus in 7 days when less than 1% lymphoma cells were cocultured with 100-fold excess of neonatal stroma cells, representing 3.2-fold higher proliferative rate than 2D coculture model. The lymphoma cells grew and aggregated to form clusters during 3D coculture and did not maintained the parental phenotype to grow in single-cell suspension. The cluster size was over 5-fold bigger in the 3D coculture by day 4 than 2D coculture system and contained less than 0.00001% of neonatal fibroblast trace. This preliminary data indicate that novel 3D scaffold geometry and coculturing environment can be customized to amplify primary cancer cells from blood or tissues related to hematological cancer and subsequently used for personalized drug screening procedures

Putative spin liquid in the triangle-based iridate Ba3_3IrTi2_2O9_9

We report on thermodynamic, magnetization, and muon spin relaxation measurements of the strong spin-orbit coupled iridate Ba$_3$IrTi$_2$O$_9$, which constitutes a new frustration motif made up a mixture of edge- and corner-sharing triangles. In spite of strong antiferromagnetic exchange interaction of the order of 100~K, we find no hint for long-range magnetic order down to 23 mK. The magnetic specific heat data unveil the $T$-linear and -squared dependences at low temperatures below 1~K. At the respective temperatures, the zero-field muon spin relaxation features a persistent spin dynamics, indicative of unconventional low-energy excitations. A comparison to the $4d$ isostructural compound Ba$_3$RuTi$_2$O$_9$ suggests that a concerted interplay of compass-like magnetic interactions and frustrated geometry promotes a dynamically fluctuating state in a triangle-based iridate.Comment: Physical Review B accepte

Two-step kinetics of As/P exchange reaction

A simple two-step mechanism is used to derive the kinetics of the As/P exchange reaction which takes place on an epitaxially grown InP surface exposed to As flux. The first step involves surface exchange of arsenic with phosphorus, which is then followed by the second step, bulk exchange of arsenic (arsenic incorporation). Two possible choices are investigated for bulk exchange: the same exchange rate constant in the bulk and the same ratio of exchange rate constants in the bulk. Transient and steady-state profiles of As composition and the maximum depth of the As/P exchange reaction are derived analytically