In vitro effects of a chemical inhibitor targeting superoxide dismutase on the growth of Trichomonas vaginalis

Trichomonas vaginalis is a protozoal pathogen infecting both men and women, causing the disease trichomoniasis, one of the most common sexually-transmitted diseases. Currently, there are only two FDA-approved treatments, metronidazole and tinidazole; however, drug resistance remains a threat in treating the disease. Due to few treatments available, we are screening new compounds to see if they inhibit the growth of the organism. This study focuses on the role of superoxide dismutase on in vitro growth. Superoxide dismutase is an enzyme that eliminates harmful superoxide ions that damage cells. Using the SOD inhibitor, sodium diethylthiocarbamate trihydrate, we are testing whether treatment with this compound can inhibit in vitro growth of T. vaginalis; as well as determine whether abrogation of SOD activity increases metronidazole susceptibility of the organism. This work may highlight new opportunities for alternative chemotherapies against T. vaginalis

In vitro effects of a chemical inhibitor targeting superoxide dismutase on the growth of Trichomonas vaginalis

Trichomonas vaginalis is a protozoal pathogen infecting both men and women, causing the disease trichomoniasis, one of the most common sexually-transmitted diseases. Currently, there are only two FDA-approved treatments, metronidazole and tinidazole; however, drug resistance remains a threat in treating the disease. Due to few treatments available, we are screening new compounds to see if they inhibit the growth of the organism. This study focuses on the role of superoxide dismutase on in vitro growth. Superoxide dismutase is an enzyme that eliminates harmful superoxide ions that damage cells. Using the SOD inhibitor, sodium diethylthiocarbamate trihydrate, we are testing whether treatment with this compound can inhibit in vitro growth of T. vaginalis; as well as determine whether abrogation of SOD activity increases metronidazole susceptibility of the organism. This work may highlight new opportunities for alternative chemotherapies against T. vaginalis