7 research outputs found
Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation
A small G protein, RalA, was identified as a binding partner of PKCη. The binding led to activation of RalA and actin depolymerization associated with keratinocyte differentiation. These results provide new insight into the molecular mechanism of cytoskeletal regulation that leads to drastic change of cell shape