451 research outputs found
Self-Adjusting Biofeedback with a Dynamic Feedback Signal Set (DyFSS)
Abstract - A lack of control over their autonomic nervous system presents a major challenge for many children with Autism Spectrum Disorder (ASD). Autonomic biofeedback training is a promising treatment for managing anxiety and ASD symptoms more generally. We describe software that tunes four autonomic measurements to the best abilities and needs of each individual patient. Using this dynamic feedback signal set (DyFSS), a strength-based, self-customizing algorithm, we aim to address the autonomic heterogeneity of youth with ASD. The DyFSS may improve autonomic biofeedback training for the user by making it more understandable and easier to accomplish. Because it is self-adjusting, it may also ease the integration of autonomic biofeedback training into clinical work. Initial feasibility testing of this algorithm in youth with ASD with a five-session autonomic biofeedback training protocol showed improved behavior in relation to ASD symptoms Initial reactions show that youth with ASD are readily engaged through technological interventions such as autonomic biofeedback
Duhamel versus transanal endorectal pull through (TERPT) for the surgical treatment of Hirschsprungâs disease
For the surgical treatment of Hirschsprungâs disease, several surgical techniques are used to resect the distal aganglionic colon. Two frequently used techniques are the Duhamel procedure and the transanal endorectal pull-through procedure. During the â8th Pediatric Colorectal Courseâ in Nijmegen, November 2015, a workshop was organized to share experiences of both techniques by several experts in the field and to discuss (long term) outcomes. Specifically, the objective of the meeting was to discuss the main controversies in relation to the technical execution of both procedures in order to make an initial assessment of the limitations of available evidence for clinical decision-making and to formulate a set of preliminary recommendations for current clinical care and future research
Improving the Graphical User Interface (GUI) for the Dynamic Feedback Signal Set (DyFSS): Increasing Accessibility for the Neurodiverse
Peripheral biofeedback is an explicit learning tool
that allows for real-time evaluation and control of physiological
proxies by means of computerized signals. Its integration into
health practice allows users to calibrate self-awareness and self regulation
then apply these skills to everyday life. People with
neurodevelopmental differences encounter limitations when
using commercially available clinical biofeedback due to
variation in their autonomic response. Principles of Universal
Design dictate that biofeedback inputs and displays allow
effective access and benefit for as many individuals as possible.
Our Dynamic Feedback Signal Set (DyFSS, nonprovisional
patent-in-process) algorithm adjusts signal processing by
dynamically weighting feedback signals to the best abilities of the
user, increasing the efficacy of biofeedback for the neurodiverse.
The software includes an interactive graphical tutorial and quiz,
a variety of graphical user interfaces to honor individual
preferences and abilities, and a game that can be played by blind
and hard of hearing individuals alike
Self-Adjusting Biofeedback with a Dynamic Feedback Signal Set (DyFSS)
A lack of control over their autonomic nervous system presents a major challenge for many children with Autism Spectrum Disorder (ASD). Autonomic biofeedback training is a promising treatment for managing anxiety and ASD symptoms more generally. We describe software that tunes four autonomic measurements to the best abilities and needs of each individual patient. Using this dynamic feedback signal set (DyFSS), a strength-based, self-customizing algorithm, we aim to address the autonomic heterogeneity of youth with ASD. The DyFSS may improve autonomic biofeedback training for the user by making it more understandable and easier to accomplish. Because it is self-adjusting, it may also ease the integration of autonomic biofeedback training into clinical work. Initial feasibility testing of this algorithm in youth with ASD with a five-session autonomic biofeedback training protocol showed improved behavior in relation to ASD symptoms Initial reactions show that youth with ASD are readily engaged through technological interventions such as autonomic biofeedback. Keywordsâ autism spectrum disorder; autonomi
Recoil Studies in the Reaction of 12-C Ions with the Enriched Isotope 118-Sn
The recoil properties of the product nuclei from the interaction of 2.2
GeV/nucleon 12-C ions from Nuclotron of the Laboratory of High Energies (LHE),
Joint Institute for Nuclear Research (JINR) at Dubna with a 118-Sn target have
been studied using catcher foils. The experimental data were analyzed using the
mathematical formalism of the standard two-step vector model. The results for
12-C ions are compared with those for deuterons and protons. Three different
Los Alamos versions of the Quark-Gluon String Model (LAQGSM) were used for
comparison with our experimental data.Comment: 10 pages, 6 figures, submitted to Nucl. Phys.
RBCK1ârelated disease: A rare multisystem disorder with polyglucosan storage, autoâinflammation, recurrent infections, skeletal, and cardiac myopathyâFour additional patients and a review of the current literature
In this article, we report four new patients, from three kindreds, with pathogenic variants in RBCK1 and a multisystem disorder characterised by widespread polyglucosan storage. We describe the clinical presentation of progressive skeletal and cardiac myopathy, combined immunodeficiencies and autoâinflammation, illustrate in detail the histopathological findings in multiple tissue types, and report muscle MRI findings
A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease
We examined baseline and longitudinal associations between plasma neurofilament light (NfL) and total tau (t-tau), and the clinical presentation of Alzheimer's disease (AD). A total of 579 participants (238, normal cognition [NC]; 185, mild cognitive impairment [MCI]; 156, AD dementia) had baseline blood draws; 82% had follow-up evaluations. Plasma samples were analyzed for NfL and t-tau using Simoa technology. Baseline plasma NfL was higher in AD dementia than MCI (standardized mean difference = 0.55, 95% CI: 0.37â0.73) and NC (standardized mean difference = 0.68, 95% CI: 0.49â0.88), corresponded to Clinical Dementia Rating scores (OR = 1.94, 95% CI: 1.35â2.79]), and correlated with all neuropsychological tests (r's = 0.13â0.42). Longitudinally, NfL did not predict diagnostic conversion but predicted decline on 3/10 neuropsychological tests. Baseline plasma t-tau was higher in AD dementia than NC with a small effect (standardized mean difference = 0.33, 95% CI: 0.10â0.57) but not MCI. t-tau did not statistically significant predict any longitudinal outcomes. Plasma NfL may be useful for the detection of AD dementia and monitoring of disease progression. In contrast, there was minimal evidence in support of plasma t-tau
Systemic epidermal nevus with involvement of the oral mucosa due to FGFR3 mutation
Our results show that activating FGFR3 mutations can also affect the oral mucosa and that extracutaneous manifestations of EN syndrome can be subtle. We highlight the theoretical risk of the patient having an offspring with thanatophoric dysplasia as gonadal mosaicism for the R248C mutation cannot be excluded
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