A Review on Hot Melt Extrusion Coupled Novel Drug Delivery Systems

The utilization of hot melt extrusion (HME) technology for new applications is increasing in recent years, as evidenced by the many published reports in the last five years. Because of its process automation and low-cost scale-up qualities, which decrease labor expenses and capital investment. HME has emerged as an essential technology for drug delivery applications in pharmaceutical research and manufacture. The novel application of the HME process provides a promising alternate approach in the formulation of novel drug delivery systems. The present review discusses the importance of HME in the development of novel drug delivery systems with the review of relevant case studies. Keywords: hot melt extrusion, novel drug delivery, pharmaceutical researc

Development and evaluation of itraconazole solid dispersion gel for cutaneous delivery

Objective: The objective of this research is to enhance the permeation of low bioavailable drugs with suitable dosage forms by utilizing various permeation enhancers.  Methods: Solid dispersions (SDs) were prepared by kneading, whereas physical mixtures (PM) were prepared by simple mixing with polymers PEG 6000 and PEG 20000 and evaluated for various physicochemical parameters. Optimized SDs were converted to gels using a variety of polymers and were evaluated for in vitro and ex vivo permeation studies.  Results: It was found that the percentage of drugs in SDs and PMs was within the limit. The dissolution of SDs and PMs was found to be the highest with PEG-6000 (99.78% within 240 min) compared to PEG 20000. The maximum drug release (92.9% within 8 hours) was achieved with oleic acid in both in vitro and ex vivo permeation studies, as evidenced by the in vitro and ex vivo permeation studies. The developed formulations showed no incompatibility between drugs and excipients, as demonstrated by drug and excipient interaction studies. Conclusion: The results that were observed confirmed that the itraconazole PEG-6000 gel developed has promising effects on desirable skin permeation