FORMULATION AND STABILITY EVALUATION OF KETOPROFEN LOADED VIRGIN COCONUT OIL BASED CREAMY EMULSION

Objective: To formulate and optimize a topical formulation; a virgin coconut oil (VCO) based Ketoprofen loaded creamy emulsion containing Tween 80® as the surfactant and to evaluate the stability of samples. Methods: In preformulatory studies optimization of the formulae was done using ternary phase diagrams with water titration method and emulsions were formulated using two methods; spontaneous emulsification and homogenization. Their stability was analyzed under visual observation to optimize the best formulae for Ketoprofen incorporated creamy emulsion. 2.5% w/w Ketoprofen topical formulations are available in the market. Results: Centrifugation provided more comparable data than visual observation. Phase separation was the main instability condition observed in unstable emulsions. Composition 23.60% VCO: 29.53% Tween 80®: 45.87% water was identified as the best optimized formulae in both with and without Ketoprofen formulations and all the samples with different Ketoprofen concentrations were stable for 14 days under centrifugation and visual observation stability studies. Conclusion: Homogenization was more effective in stable emulsion formation than spontaneous emulsification in VCO, Tween 80®,water emulsion. The best optimized formula was 23.60% VCO: 29.53% Tween 80®: 45.87% water

AWARENESS OF USAGE OF SUNSCREENS AMONG SCHOOL CHILDREN IN KANDY, SRI LANKA

Objective: The objective of this research was to evaluate the awareness of usage of sunscreens among school children in Kandy, Sri Lanka.Methods: School children (138) who do outdoor sports were recruited from six schools. Knowledge and attitudes towards the usage and application of sunscreens were assessed using a researcher administered questionnaire. Statistical analyses were done using Statistical Package for the Social Science (SPSS version-16).Results: Among the school children who do outdoor sports, 71 (51.4%) of participants used sunscreens and 67 (48.6%) of participants did not use sunscreens.Conclusion: According to the results most of the school children have a lack of knowledge, attitudes and practice towards the usage of sunscreens

COMPARATIVE IN-VITRO EVALUATION OF METFORMIN HCl AND PARACETAMOL TABLETS COMMERCIALLY AVAILABLE IN KANDY DISTRICT, SRI LANKA

Objective: Availability of numerous brands of tablets with price variations compared to their generic drugs in the current drug market places health practitioners, pharmacists and patients in a dilemma of generic substitution. In such background, this study was aimed to compare the in-vitro efficacy of some of the low priced generic tablets with their brands commonly available in Sri Lanka.Methods: A survey of the prices of commonly used tablets and capsules available at pharmacies in Kandy area in Sri Lanka was carried out. Based on the results of the survey, frequently used two tablets; Metformin HCl (one locally manufactured generic (M1) and 3 brands M2-M4) and Paracetamol (one locally manufactured generic (P1) and two brands P2-P3) were selected for the study. All the products were examined visually for their organoleptic properties and tested for uniformity of weight, disintegration time, assay value, dissolution rate, hardness or crushing strength and friability. Pertinent official guidelines were followed throughout all the tests.Results: The results of aesthetic assessment showed no sign of defects and all the tested tablets complied with the official standards for the above parameters. Despite some minor differences in tablet hardness and disintegration time profiles, other in-vitro characteristics of the tested brands; Paracetamol and Metformin HCl and their locally manufactured generics appears to be similar and not significantly different from each other.Conclusion: According to in-vitro official quality control tests, all the generics and brands of the respective drugs tested could be regarded as equally effective.Â

Evaluation of biochemical profile of Chronic Kidney Disease of uncertain etiology in Sri Lanka.

Chronic Kidney Disease of uncertain etiology (CKDu) is an endemic, disease that mostly affects young agricultural workers in the rural dry zone of Sri Lanka. This study was designed to identify specific biochemical manifestations of CKDu cases. All (119) non-dialysis definite CKDu patients in Girandurukotte and Wilgamuwa were selected. Blood and urine samples were collected and measured biochemical parameters. All analyses were performed in IBM SPSS statistics version 23 (IBM Corp, USA). The median blood pressure was normal though nearly half of the patients (45.4%) who were in the advanced stages (Stage 3b, 4 and 5) of CKDu. Patients without a history of hypertension before the diagnosis of CKDu (100%) and minimal proteinuria (26%) are similar to the previous findings. Patients without a history of diabetes before the CKDu diagnosis had high percentages of diabetes (15.7%) and pre-diabetes (59.8%) and hence indicated the possibility of uremia induced impaired glucose intolerance in the rural areas of the country. There were 62.2% patients who had low vitamin D and only a minority had evidence of bone mineral diseases. Out of liver disease markers serum glutamic pyruvic transaminases (SGPT), serum glutamic oxaloacetic transaminases (SGOT), gamma-glutamyl transferase (GGT), and Lactic acid degydrogenase (LDH) had an inverse correlation with the advancement of the disease indicating subclinical liver disease. Osmolality in serum and urine showed a discrepancy despite > 50% of CKDu patients had increased their serum osmolality. The current study supports most of the previously described manifestations of CKDu. Moreover, some specific patterns have been identified which need to be validated in a larger group