Substantiation of thermomechanical technology parameters of absorbing levels isolation of the boreholes

The aim of the work is to improve the thermomechanical absorption insulation technology horizons of drilling wells by the established regularities of change and the substantiation of its regime parameters from the composition and physical-mechanical properties strengthen thermoplastic composite material and, on this basis, development a technological regulation containing recommendations on the manufacture of composites and organizations laying work, designing and isolation of the absorption zones of the washing liquid in the drilling rigs wells. The tasks set were solved by complex method research that contains analysis and synthesis of literary and patent sources, conducting analytical, experimental and industrial research. Experimental processing data was carried out using methods of mathematical statistics. Experimental research is carried out using the provisions of the theory of scientific experiment and theory random processes. The evaluation of the effectiveness of the results was carried out in production conditions

ВИКОРИСТАННЯ МОЛОЧНОЇ СИРОВАТКИ В ТЕХНОЛОГІЇ ОДЕРЖАННЯ БІОМІНЕРАЛЬНИХ ДОБРИВ З ВІДХОДІВ

The relevance of finding new methods for intensifying the process of obtaining biomineral fertilizers in the anaerobic digestion reactor has been pointed out. The efficiency and effectiveness of milk whey for intensifying the process of anaerobic digestion and improving the quality of biomineral fertilizers obtained from waste products have been suggested and experimentally confirmed. In studies for the production of biomineral fertilizers, the following wastes were used in conjunction with milk whey: phosphate containing precipitate after adsorption of phosphates from urban liquid wastes by a natural sunflower husk and condensed active sludge;  cattle manure with addition of precipitates after coagulation of phosphate extraction;  household waste (%: flour – 11, potatoes – 29, apples – 27 and beets – 33) with the addition of precipitates after the coagulation of phosphates; beet pulp. It was found that with an increase in the ratio of "serum: raw materials" in the substrate from 1:4 to 1:1, the content of mineral substances rises from 5,53 to 12,15%. It has been shown and experimentally proved for the first time that the addition of milk whey to raw material (beet pulp) at a ratio of 1: 1 allows shortening the time spent by the products of processing in the reactor for the production of biomineral fertilizers by 1,5-2,2 times. The highest content of nutrients (%: N – 5,2; P – 5,02; K – 10,1; Cа – 9,85) was found in biomineral fertilizer obtained from a phosphate containing precipitate after processing of urban liquid waste with a natural sunflower based adsorbent  husk and sealed active sludge ferrum(III) chloride. The production tests of the obtained biomineral fertilizers in the technology of growing barley of the spring type «Stalker» and «Tsarevich» varieties are carried out.It has been shown that biomineral fertilizers obtained from waste with the addition of milk whey correspond to the current standards ofUkraineon the content of macro- and micronutrients.The relevance of finding new methods for intensifying the process of obtaining biomineral fertilizers in the anaerobic digestion reactor has been pointed out. The efficiency and effectiveness of milk whey for intensifying the process of anaerobic digestion and improving the quality of biomineral fertilizers obtained from waste products have been suggested and experimentally confirmed. In studies for the production of biomineral fertilizers, the following wastes were used in conjunction with milk whey: phosphate containing precipitate after adsorption of phosphates from urban liquid wastes by a natural sunflower husk and condensed active sludge;  cattle manure with addition of precipitates after coagulation of phosphate extraction;  household waste (%: flour – 11, potatoes – 29, apples – 27 and beets – 33) with the addition of precipitates after the coagulation of phosphates; beet pulp. It was found that with an increase in the ratio of "serum: raw materials" in the substrate from 1:4 to 1:1, the content of mineral substances rises from 5,53 to 12,15%. It has been shown and experimentally proved for the first time that the addition of milk whey to raw material (beet pulp) at a ratio of 1: 1 allows shortening the time spent by the products of processing in the reactor for the production of biomineral fertilizers by 1,5-2,2 times. The highest content of nutrients (%: N – 5,2; P – 5,02; K – 10,1; Cа – 9,85) was found in biomineral fertilizer obtained from a phosphate containing precipitate after processing of urban liquid waste with a natural sunflower based adsorbent  husk and sealed active sludge ferrum(III) chloride. The production tests of the obtained biomineral fertilizers in the technology of growing barley of the spring type «Stalker» and «Tsarevich» varieties are carried out.It has been shown that biomineral fertilizers obtained from waste with the addition of milk whey correspond to the current standards ofUkraineon the content of macro- and micronutrients

Thermal effects of carbonated hydroxyapatite modified by glycine and albumin

In this work calcium phosphate powders were obtained by precipitation method from simulated solutions of synovial fluid containing glycine and albumin. X-ray diffraction and IR spectroscopy determined that all samples are single-phase and are presented by carbonate containing hydroxyapatite (CHA). The thermograms of solid phases of CHA were obtained and analyzed; five stages of transformation in the temperature range of 25-1000°C were marked. It is shown that in this temperature range dehydration, decarboxylation and thermal degradation of amino acid and protein connected to the surface of solid phase occur. The tendency of temperature lowering of the decomposition of powders synthesized from a medium containing organic substances was determined. Results demonstrate a direct dependence between the concentration of the amino acid in a model solution and its content in the solid phase

ОПЫТ ИСПОЛЬЗОВАНИЯ ТЕХНОЛОГИИ БИОУПРАВЛЕНИЯ В КЛИНИКЕ ПРОФЕССИОНАЛЬНЫХ ЗАБОЛЕВАНИЙ

Biofeedback in toxic encephalopathy in the late period chronic intoxication by mercury and complex toxic substances led to decrease in the EEG changes, performance improvement of the amplitude and latency evoked potentials, in vibration disease – to decrease manifestations of angiodystonia syndrome, recovery of neuromuscular conductivity. The effectiveness of biofeedback is confirmed by changes in subjective measures of the patients.Биоуправление при токсической энцефалопатии в отдаленном периоде хронической интоксикации ртутью и комплексом токсических веществ привело к уменьшению общемозговых изменений по ЭЭГ, улучшению показателей амплитуды и латентности вызванных потенциалов мозга, при вибрационной болезни – к снижению проявлений ангиодистонического синдрома, восстановлению нервно-мышечной проводимости. Эффективность биоуправления подтверждена изменениями субъективных показателей состояния пациентов

Оценка эффективности и безопасности комбинации хондроитина сульфата и глюкозамина сульфата при остеоартрите коленного и тазобедренного суставов в реальной клинической практике

A combination of chondroitin and glucosamine is widely used in clinical practice as both a symptomatic and structure-modifying agent for the treatment of osteoarthritis (OA). The emergence of new drugs based on this combination substantially expands treatment options for OA therapy.Objective: to evaluate the efficacy and safety of Artroflex® that is a combination of chondroitin sulfate 400 mg and glucosamine sulfate 500 mg (CS + GS) to support joint health in patients with knee and/or hip OA.Patients and methods. When implementing an open observational research program, the results of using the CS + GS complex were assessed in 644 OA patients (74.7% women) (mean age, 58.0±14.6 years) who experienced moderate/severe pain and required to continuously take non-steroidal anti-inflammatory drugs (NSAIDs). The CS + GS complex was prescribed in a dose of 2 capsules per day for 3 months. The investigators estimated changes in pain on movement by a 0 to 10 verbal pain scale, general health (GH) by a 0–10 visual analogue scale), the Lequesne index, the need for NSAIDs, and patient satisfaction with treatment and its tolerance.Results and discussion. After 3-month therapy, there were decreases in pain intensity by 49.2±16.8%, GH scores by 45.6±18.1%, the Lequesne index from 9.0 [6.0; 13.0] to 5.0 [3.0; 9.0]; less than half (45.2%) of the patients still needed for NSAIDs. 82.2% of patients were satisfied or completely satisfied with treatment results; 89.6% reported good treatment tolerance.Adverse events (apparently associated with NSAID use) were recorded in 2.2% of cases. There were no serious complications that required CS + GS treatment discontinuation or hospitalization.Conclusion. The findings have indicated that Artroflex® used to support joint health is an effective agent that controls OA symptoms and has a good safety level.Комбинация хондроитина и глюкозамина широко применяется в клинической практике как симптоматическое и структурно-модифицирующее средство для лечения остеоартрита (ОА). Появление новых препаратов на основе данной комбинации существенно расширяет возможности терапии ОА.Цель исследования – оценка эффективности и безопасности комплекса для поддержания здоровья суставов Артрофлекс®, представляющего собой комбинацию хондроитина сульфата 400 мг и глюкозамина сульфата 500 мг (ХС + ГС), у пациентов с ОА коленного и/или тазобедренного суставов.Пациенты и методы. В ходе наблюдательной открытой исследовательской программы были оценены результаты применения комплекса ХС + ГС у 644 больных ОА (средний возраст 58,0±14,6 года, 74,7% женщины), испытывающих умеренную/выраженную боль и нуждающихся в постоянном приеме нестероидных противовоспалительных препаратов (НПВП). Комплекс ХС + ГС назначали в дозе 2 капсулы в сутки сроком на 3 мес. Оценивали динамику боли при движении (по вербальной шкале боли 0–10), общего состояния здоровья (ОСЗ, по визуальной аналоговой шкале 0–10), индекса Лекена, потребность в приеме НПВП, удовлетворенность больных лечением и переносимостью терапии.Результаты и обсуждение. Через 3 мес применения выраженность боли снизилась на 49,2±16,8%, оценка ОСЗ – на 45,6±18,1%, индекс Лекена – с 9,0 [6,0; 13,0] до 5,0 [3,0; 9,0], необходимость в приеме НПВП осталась менее чем у половины больных (45,2%). Удовлетворены или полностью удовлетворены результатами лечения были 82,2% больных, хорошую переносимость терапии отметили 89,6%. Нежелательные явления (по-видимому, связанные с приемом НПВП) зафиксированы в 2,2% случаев. Серьезных осложнений, потребовавших прерывания лечения ХС + ГС или госпитализации, не выявлено.Заключение. Согласно полученным данным, комплекс для поддержания здоровья суставов Артрофлекс® – эффективное средство для контроля симптомов ОА, обладающее хорошим уровнем безопасности

Evaluation of the efficacy and safety of a combination of chondroitin sulfate and glucosamine sulfate for knee and hip osteoarthritis in real clinical practice

A combination of chondroitin and glucosamine is widely used in clinical practice as both a symptomatic and structure-modifying agent for the treatment of osteoarthritis (OA). The emergence of new drugs based on this combination substantially expands treatment options for OA therapy.Objective: to evaluate the efficacy and safety of Artroflex® that is a combination of chondroitin sulfate 400 mg and glucosamine sulfate 500 mg (CS + GS) to support joint health in patients with knee and/or hip OA.Patients and methods. When implementing an open observational research program, the results of using the CS + GS complex were assessed in 644 OA patients (74.7% women) (mean age, 58.0±14.6 years) who experienced moderate/severe pain and required to continuously take non-steroidal anti-inflammatory drugs (NSAIDs). The CS + GS complex was prescribed in a dose of 2 capsules per day for 3 months. The investigators estimated changes in pain on movement by a 0 to 10 verbal pain scale, general health (GH) by a 0–10 visual analogue scale), the Lequesne index, the need for NSAIDs, and patient satisfaction with treatment and its tolerance.Results and discussion. After 3-month therapy, there were decreases in pain intensity by 49.2±16.8%, GH scores by 45.6±18.1%, the Lequesne index from 9.0 [6.0; 13.0] to 5.0 [3.0; 9.0]; less than half (45.2%) of the patients still needed for NSAIDs. 82.2% of patients were satisfied or completely satisfied with treatment results; 89.6% reported good treatment tolerance.Adverse events (apparently associated with NSAID use) were recorded in 2.2% of cases. There were no serious complications that required CS + GS treatment discontinuation or hospitalization.Conclusion. The findings have indicated that Artroflex® used to support joint health is an effective agent that controls OA symptoms and has a good safety level

Developing Ways of Synthesizing Quality Hydrolyzates Based on Integrating Catalytic Peroxide Delignification and the Acid Hydrolysis of Birch Wood

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