NEXT: Generating tailored ERP applications from ontological enterprise models

Tailoring Enterprise Resource Planning (ERP) software to the needs of the enterprise still is a technical endeavor, often requiring the (de)activation of modules, modification of configuration files or even execution of database queries. Considering the large body of work on Enterprise Modeling and Model-Driven Software Engineering, this is remarkable: Ideally, one models one’s own enterprise and, at the press of a button, ERP software tailored to the needs of the modeled enterprise is generated. In this paper, we introduce NEXT, a novel model-driven software generation approach being developed with precisely this goal in mind. It uses the expressive power of ontological enterprise models (OEMs) to generate ERP cloud applications. An OEM only describes the real-world phenomena essential to the enterprise, using terms and customizations specific to the enterprise. We present our considerations during development of the OEM modeling language, which is designed to capture the specifics of enterprise phenomena in a way that technical details can be derived from it. We expect NEXT to drastically shorten the time-to-market of ERP software, from months–years to hours–days

Identification of a tumor-specific allo-HLA-restricted γδTCR

γδT cells are key players in cancer immune surveillance because of their ability to recognize malignant transformed cells, which makes them promising therapeutic tools in the treatment of cancer. However, the biological mechanisms of how γδT-cell receptors (TCRs) interact with their ligands are poorly understood. Within this context, we describe the novel allo-HLA-restricted and CD8α-dependent Vγ5Vδ1TCR. In contrast to the previous assumption of the general allo-HLA reactivity of a minor fraction of γδTCRs, we show that classic anti-HLA-directed, γδTCR-mediated reactivity can selectively act on hematological and solid tumor cells, while not harming healthy tissues in vitro and in vivo. We identified the molecular interface with proximity to the peptide-binding groove of HLA-A*24:02 as the essential determinant for recognition and describe the critical role of CD8 as a coreceptor. We conclude that alloreactive γδT-cell repertoires provide therapeutic opportunities, either within the context of haplotransplantation or as individual γδTCRs for genetic engineering of tumor-reactive T cells