Novel Phenomena of the Hartle–Hawking Wave Function

We find a novel phenomenon in the solution to the Wheeler–DeWitt equation by solving numerically the equation assuming O(4)-symmetry and imposing the Hartle–Hawking wave function as a boundary condition. In the slow-roll limit, as expected, the numerical solution gives the most dominant steepest-descent that describes the probability distribution for the initial condition of a universe. The probability is consistent with the Euclidean computations, and the overall shape of the wave function is compatible with analytical approximations, although there exist novel differences in the detailed probability computation. Our approach gives an alternative point of view for the no-boundary wave function from the wave function point of view. Possible interpretations and conceptual issues of this wave function are discussed

Controlled growth of a graphene charge-floating gate for organic non-volatile memory transistors

We report memory application for graphene as a floating gate in organic thin-film transistor (OTFT) structure. For graphene floating gate, we demonstrate a simpler synthesis method to form a discrete graphene layer by controlling the growth time during a conventional CVD process. The resulting organic memory transistor with the discrete graphene charge-storage layer is evaluated. The device was demonstrated based on solution-processed tunneling dielectric layers and evaporated pentacene organic semiconductor. The resulting devices exhibited programmable memory characteristics, including threshold voltage shifts (similar to 28 V) in the programmed/erased states when an appropriate gate voltage was applied. They also showed an estimated long data retention ability and program/erase cycles endurance more than 100 times with reliable non-volatile memory properties although operated without encapsulation and in an ambient condition. (C) 2015 Elsevier B.V. All rights reserved

Roll-to-roll continuous patterning and transfer of graphene via dispersive adhesion

We present a roll-to-roll, continuous patterning and transfer of graphene sheets capable of residue-free and fast patterning. The graphene sheet is supported with dispersive adhesion. Graphene is continuously patterned by the difference in adhesion forces with a pre-defined embossed roller. The patterned graphene sheet adheres to the polyethylene terephthalate (PET)/silicone with very low strength and can be easily transferred to various substrates without the aid of any heating mechanism. The width of the patterned film was 120 mm and a production rate of 15 m min(-1) for patterning was achieved. Large-area uniformity was confirmed by observing the optical images on 4 inch Si wafer and Raman mapping spectra for 50 x 50 mm(2)

Stable n-type doping of graphene via high-molecular-weight ethylene amines

We demonstrate a stable and strong n-type doping method to tune the electrical properties of graphene via vapor phase chemical doping with various high-molecular-weight ethylene amines. The resulting carrier concentration after doping with pentaethylenehexamine (PEHA) is as high as -1.01 x 10(13) cm(-2), which reduces the sheet resistance of graphene by up to similar to 400% compared to pristine graphene. Our study suggests that the branched structure of the dopant molecules is another important factor that determines the actual doping degree of graphene

High-performance polymer light emitting diodes with interface-engineered graphene anodes

Recently, graphene-based organic light emitting diodes (OLEDs) were successfully demonstrated using graphene as anodes. However, the graphene electrodes have not been utilized for polymer light emitting diodes (PLEDs) yet, although the simpler device structure and the solution-based fabrication process of PLEDs are expected to be more advantageous in terms of time and cost. Here we demonstrate high-performance polymer light emitting diodes (PLEDs) with simple two-layer structures using interface-engineered single-layer graphene films as anodes. The single-layer graphene synthesized by chemical vapor deposition methods was transferred onto a glass substrate utilizing an elastic stamp, and its work function was engineered by varying the duration and the power of ultraviolet ozone (UVO) treatment. Thus, we were able to optimize the contact between silver electrodes and the graphene anodes, leading to the considerable enhancement of light-emitting performance. (C) 2013 Elsevier B.V. All rights reserved.This work was supported by the OLED center of Samsung Display and Seoul National University, the Industrial Strategic Technology Development Program (KI002104, Development of Fundamental Technologies for Flexible Combined-Function Organic Electronic Device), the Global Research Lab (GRL) Program (2011-0021972), the Global Frontier Research Program (2011-0031627), and the Basic Science Research Program (2012M3A7B4049807, 2011-0017587 and 2009-0083540) through the National Research Foundation of Korea (NRF) funded by the Korean government (MEST and MKE).OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000029430/3SEQ:3PERF_CD:SNU2013-01EVAL_ITEM_CD:102USER_ID:0000029430ADJUST_YN:YEMP_ID:A076109DEPT_CD:430CITE_RATE:3.836FILENAME:organic electronics 14, 2324 (sep, 2013).pdfDEPT_NM:전기·정보공학부EMAIL:[email protected]_YN:YCONFIRM:

Graphene- Regulated Cardiomyogenic Differentiation Process of Mesenchymal Stem Cells by Enhancing the Expression of Extracellular Matrix Proteins and Cell Signaling Molecules

The potential of graphene as a mesenchymal stem cell (MSC) culture substrate to promote cardiomyogenic differentiation is demonstrated. Graphene exhibits no sign of cytotoxicity for stem cell culture. MSCs are committed toward cardiomyogenic lineage by simply culturing them on graphene. This may be attributed, at least partially, to the regulation of expression levels of extracellular matrix and signaling molecules

Multiscale Modulation of Nanocrystalline Cellulose Hydrogel via Nanocarbon Hybridization for 3D Neuronal Bilayer Formation

Bacterial biopolymers have drawn much attention owing to their unconventional three-dimensional structures and interesting functions, which are closely integrated with bacterial physiology. The nongenetic modulation of bacterial (Acetobacter xylinum) cellulose synthesis via nanocarbon hybridization, and its application to the emulation of layered neuronal tissue, is reported. The controlled dispersion of graphene oxide (GO) nanoflakes into bacterial cellulose (BC) culture media not only induces structural changes within a crystalline cellulose nanofibril, but also modulates their 3D collective association, leading to substantial reduction in Young's modulus (approximate to 50%) and clear definition of water-hydrogel interfaces. Furthermore, real-time investigation of 3D neuronal networks constructed in this GO-incorporated BC hydrogel with broken chiral nematic ordering revealed the vertical locomotion of growth cones, the accelerated neurite outgrowth (approximate to 100 mu m per day) with reduced backward travel length, and the efficient formation of synaptic connectivity with distinct axonal bifurcation abundancy at the approximate to 750 mu m outgrowth from a cell body. In comparison with the pristine BC, GO-BC supports the formation of well-defined neuronal bilayer networks with flattened interfacial profiles and vertical axonal outgrowth, apparently emulating the neuronal development in vivo. We envisioned that our findings may contribute to various applications of engineered BC hydrogel to fundamental neurobiology studies and neural engineering

Graphene Potentiates the Myocardial Repair Efficacy of Mesenchymal Stem Cells by Stimulating the Expression of Angiogenic Growth Factors and Gap Junction Protein

Stem cell therapy has emerged as a potential modality for myocardial infarction treatment. Mesenchymal stem cells (MSCs) exert reparative actions in the injured myocardium mainly through the secretion of paracrine factors. In addition, the overexpression of connexin 43 (Cx43), a gap junction protein, promotes cardiac repair and function restoration. It is known that MSCs in a spheroid form, which have enhanced cell-cell interaction, exhibit enhanced expression of paracrine factors and Cx43. However, cell-extracellular matrix (ECM) interactions, which also contribute to growth factor expression, are very limited in MSC spheroids. Reduced graphene oxide (RGO) shows high affinity toward ECM proteins, such as fibronectin (FN), and high electrical conductivity. In this study, by incorporating FN-adsorbed RGO flakes into MSC spheroids, it is possible to enhance the cell-ECM interactions and, subsequently, the paracrine factor expression in the MSCs in spheroids. Cx43 is also upregulated likely due to the enhanced paracrine factor expression and electrical conductivity of RGO. The injection of MSC-RGO hybrid spheroids into the infarcted hearts enhances cardiac repair compared with the injection of RGO flakes or MSC spheroids. This study demonstrates that RGO can effectively improve the therapeutic efficacy of MSCs for ischemic heart diseases

In situ hybridization of carbon nanotubes with bacterial cellulose for three-dimensional hybrid bioscaffolds

Carbon nanotubes (CNTs) have shown great potential in biomedical fields. However, in vivo applications of CNTs for regenerative medicine have been hampered by difficulties associated with the fabrication of three-dimensional (3D) scaffolds of CNTs due to CNTs' nano-scale nature. In this study, we devised a new method for biosynthesis of CNT-based 3D scaffold by in situ hybridizing CNTs with bacterial cellulose (BC), which has a structure ideal for tissue-engineering scaffolds. This was achieved simply by culturing Gluconacetobacter xylinus, BC-synthesizing bacteria, in medium containing CNTs. However, pristine CNTs aggregated in medium, which hampers homogeneous hybridization of CNTs with BC scaffolds, and the binding energy between hydrophobic pristine CNTs and hydrophilic BC was too small for the hybridization to occur. To overcome these problems, an amphiphilic comb-like polymer (APCLP) was adsorbed on CNTs. Unlike CNT-coated BC scaffolds (CNT-BC-Imm) formed by immersing 3D BC scaffolds in CNT solution, the APCLP-adsorbed CNT-BC hybrid scaffold (CNT-BC-Syn) showed homogeneously distributed CNTs throughout the 3D microporous structure of BC. Importantly, in contrast to CNT-BC-Imm scaffolds, CNT-BC-Syn scaffolds showed excellent osteoconductivity and osteoinductivity that led to high bone regeneration efficacy. This strategy may open a new avenue for development of 3D biofunctional scaffolds for regenerative medicine. (C) 2015 Elsevier Ltd. All rights reserved

Bacterial Cellulose Nanofibrillar Patch as a Wound Healing Platform of Tympanic Membrane Perforation

Bacterial cellulose (BC)-based biomaterials on medical device platforms have gained significant interest for tissue-engineered scaffolds or engraftment materials in regenerative medicine. In particular, BC has an ultrafine and highly pure nanofibril network structure and can be used as an efficient wound-healing platform since cell migration into a wound site is strongly meditated by the structural properties of the extracellular matrix. Here, the fabrication of a nanofibrillar patch by using BC and its application as a new wound-healing platform for traumatic tympanic membrane (TM) perforation is reported. TM perforation is a very common clinical problem worldwide and presents as conductive hearing loss and chronic perforations. The BC nanofibrillar patch can be synthesized from Gluconacetobacter xylinus; it is found that the patch contained a network of nanofibrils and is transparent. The thickness of the BC nanofibrillar patch is found to be approximately 10.33 +/- 0.58 m, and the tensile strength and Young's modulus of the BC nanofibrillar patch are 11.85 +/- 2.43 and 11.90 +/- 0.48 MPa, respectively, satisfying the requirements of an ideal wound-healing platform for TM regeneration. In vitro studies involving TM cells show that TM cell proliferation and migration are stimulated under the guidance of the BC nanofibrillar patch. In vivo animal studies demonstrate that the BC nanofibrillar patch promotes the rate of TM healing as well as aids in the recovery of TM function. These data demonstrate that the BC nanofibrillar patch is a useful wound-healing platform for TM perforation