La pandemia por COVID-19, su implicación con las emociones y las barreras de aprendizaje en educación superior

El objetivo del artículo fue analizar los factores que integran aspectos de la pandemia por COVID-19, de las emociones y de las barreras de aprendizaje durante la modalidad educativa establecida por las instituciones desde la perspectiva del estudiantado de educación superior. La metodología empleada fue cuantitativa, transversal y descriptiva; la recopilación de las respuestas fue a través de un instrumento de elaboración propia. Las propiedades psicométricas de la encuesta se exploraron por medio de la consistencia interna con el método de alfa de Cronbach, con el que se obtuvo un coeficiente para toda la escala de 0.93 en las variables que conforman los tres ejes analizados. La muestra se conformó por 320 personas encuestadas mediante el muestreo no probabilístico por conveniencia. Los análisis estadísticos procesados fueron frecuencias y porcentajes, comparativo e integración con el factorial exploratorio. La aportación del estudio reside en las pruebas estadísticas que permiten concluir que la pandemia por COVID-19, durante la modalidad educativa establecida por las instituciones, es un escenario para señalar su conexión con las emociones y las barreras de aprendizaje en tiempos de contingencia. Se destaca que la mayoría de la comunidad estudiantil presentó características emocionales que, a pesar de las dificultades que trae consigo una contingencia sanitaria, fue asertiva en el manejo de emociones. Sin embargo, otra parte del estudiantado se caracterizó por experimentar emociones que coartan su tranquilidad emocional; además, se observó conocimiento acerca de la pandemia en relación con aspectos de cómo actuar para evitar contagiarse, entre otros. En controversia con lo anterior, la perspectiva de un porcentaje menor de la muestra fue buscar la interpretación del fenómeno desde el plano de lo mágico y religioso. Se destaca que las características del seno familiar impactaron en situaciones emocionales y escolares, además, se denotan factores de oportunidad para las Instituciones de Educación Superior (IES) en la capacitación del alumnado para fortalecer sus competencias digitales y emocionales.

Propuesta académica de formación en responsabilidad social, dirigida a las partes interesadas en el municipio de Tuluá Valle del Cauca

ilustraciones, gráficos, tablasLa responsabilidad social es un tema relativamente nuevo en nuestro País y más aún en nuestra comunidad, el evidente desconocimiento sobre el concepto, su poca aplicación y la falla de voluntad de los empresarios por incorporarla en sus objetivos organizacionales, han sido plasmados por diferentes autores que sirvieron de antecedentes para el fundamento de esta propuesta; la cual nace como consecuencia de los hallazgos encontrados por Pérez y Rodríguez (2011), quienes documentaron el desconocimiento sobre responsabilidad social que presentaron los directivos de las grandes empresas en el municipio de Tuluá, aludiendo que actualmente no existe la cultura ni la educación que le permita a la comunidad adquirir las herramientas necesarias para el desarrollo de acciones sociales, enmarcadas en un contexto Económico y ambiental.Contador PúblicoPregrad

GENOME-WIDE ANALYSIS OF GENETIC CHANGES IN INTESTINAL-TYPE SINONASAL ADENOCARCINOMA

Abstract: Background. Intestinal-type sinonasal adenocarcinomas are rare tumors related to professional exposure to wood dust. Little is known about the genetic changes in these tumors. Methods. Twenty-two tumors were analyzed by microarray comparative genomic hybridization (CGH). In addition, DNA ploidy was measured by flow cytometry and microsatellite instability (MSI) by multiplex PCR. Results. The most frequent gains were, in descending order, as follows: 5p15, 20q13, and 8q24. Losses occurred most frequently at 4q31-qter, 18q12-22, 8p12-pter, and 5q11-qter. MSI was not detected. Seven cases that harbored very few changes were mostly DNA diploid and had more favorable clinicopathological features, such as lack of intracranial invasion, less metastases, and longer overall survival. Conclusion. The microarray CGH results enabled to better define hotspots of chromosomal gains and losses for further investigation of genes involved in the tumorigenesis of sinonasal adenocarcinoma. In addition, the data allowed classification of a group of patients with better clinical outcome. Intestinal-type sinonasal adenocarcinomas (ITACs) are epithelial tumors of the nasal cavities and paranasal sinuses, often related to professional exposure to wood dust. It is a rare neoplasm, representing 8% to 25% of all malignant sinonasal cancer. The incidence is less than 1 case per 100,000 inhabitants per year, 1-3 occurring predominately among men with a mean age of presentation of 60 to 65 years. 3 It is located most frequently (85%) in the ethmoid sinus and the upper part of the nasal cavity. It only exceptionally arises in the other sites of the nasal cavity (maxillary sinus in 10%), and these cases are usually not related to wood dust exposure. Local recurrence (30% to 60%) and invasion of the duramater constitute the main causes of death among patients, 4 whereas distant and lymph node metastasis are exceptional (5% to 10%). Standard therapeutic modalities include surgery followed by radiotherapy in advanced stages, sometimes with chemotherapy treatment. Five pathological types of sinonasal ITAC are distinguished as follows: papillary, colonic, solid, mucinous (alveolar goblet and signet ring), an

The Benzathine Penicillin G (BPG) reformulation preferences study-edging closer towards a new Penicillin for Rheumatic Fever and Rheumatic Heart Disease

Abstract Acute Rheumatic Fever (ARF) is the autoimmune condition triggered by untreated Group A Streptococcal (GAS) infection of the upper respiratory tract (and possibly skin). Severe and recurrent untreated attacks of ARF can cause cardiac damage, known as Rheumatic Heart Disease (RHD). RHD remains a significant cause of morbidity and mortality globally and in Australia, New Zealand (NZ) and the Pacific Region, the disease burden of ARF and RHD amongst Indigenous and Pacific communities is one of the highest in the world, usually affecting children and young adults. The most effective recommended preventative measure for ARF requires painful monthly intramuscular injections of Benzathine Penicillin G (BPG) for 10 years or more. Known as secondary prophylaxis, these injections aim to prevent GAS infections that may lead to recurrence of ARF and either cause or worsen RHD. Adherence to secondary prophylaxis remains a challenge in many settings and improved understanding of barriers and a BPG reformulation that is more appropriate are urgently needed. This work sought to explore the BPG reformulation preferences and perspectives of predominantly Māori and Pacific children/teens in New Zealand currently receiving monthly BPG intramuscular injections, their families and healthcare providers using three software applications developed for this purpose. A total of 82 participants comprised of children/teens, family members and health professionals have thus far participated in this research project. This is the first time software applications have been successfully developed to collect qualitative and quantitative data on individual preferences for BPG formulations and dosing regimens in New Zealand.</jats:p

Mouse Hepatic Oval Cells Require Met-Dependent PI3K to Impair TGF-b-Induced Oxidative Stress and Apoptosis

Abstract We have previously shown that oval cells harboring a genetically inactivated Met tyrosine kinase (Met 2/2 oval cells) are more sensitive to TGF-b-induced apoptosis than cells expressing a functional Met (Met flx/flx ), demonstrating that the HGF/ Met axis plays a pivotal role in oval cell survival. Here, we have examined the mechanism behind this effect and have found that TGF-b induced a mitochondria-dependent apoptotic cell death in Met flx/flx and Met 2/2 oval cells, associated with a marked increase in levels of the BH3-only proteins Bim and Bmf. Bmf plays a key role during TGF-b-mediated apoptosis since knocking down of BMF significantly diminished the apoptotic response in Met 2/2 oval cells. TGF-b also induced oxidative stress accompanied by NADPH oxidase 4 (Nox4) mRNA up-regulation and decreased protein levels of antioxidant enzymes. Antioxidants inhibit both TGF-b-induced caspase 3 activity and Bmf up-regulation, revealing an oxidative stress-dependent Bmf regulation by TGF-b. Notably, oxidative stress-related events were strongly amplified in Met 2/2 oval cells, emphasizing the critical role of Met in promoting survival. Pharmacological inhibition of PI3K did impair HGF-driven protection from TGFb-induced apoptosis and increased sensitivity of Met flx/flx oval cells to TGF-ß by enhancing oxidative stress, reaching apoptotic indices similar to those obtained in Met 2/2 oval cells. Interestingly, both PI3K inhibition and/or knockdown itself resulted in caspase-3 activation and loss of viability in Met flx/flx oval cells, whereas no effect was observed in Met 2/2 oval cells. Altogether, results presented here provide solid evidences that both paracrine and autocrine HGF/Met signaling requires PI3K to promote mouse hepatic oval cell survival against TGF-b-induced oxidative stress and apoptosis