The restoration of sediment-related disasters and driftwood from national forest in Taiwan caused by Typhoon Morakot in 2009

The number and area of new landslide, according to the interpreted SPOT images, caused by Typhoon Morakot in 2009 is estimated as 30,223 and 43,996 ha, respectively. The new landslide area in 2009 increased by about 16,392 ha in comparison with the landslide area in 2008. The heavy rainfall with a return period well over 200 years during Typhoon Morakot centralized in southwestern and southeastern Taiwan, and that also resulted in serious landslide disasters in national forest. Four forest working circles, including Chishan, Laonong, Pintung, and Dawu, are the most serious landslide zones with the landslide ratio over 8.0%. The Forestry Bureau assesses and ranks the seriousness of the disasters by using slope, the number of protected objects, the distance from the disaster to the protected objects to execute the restoration of sediment disasters and landslide in national forest. Due to the most torrential rain in the past 50 years caused by Typhoon Morakot, a large number of trees in the mountain area were destroyed. They became the driftwood, with a total weight of about 1.52 million tons, which ended up at the farmlands and ports. In order to recover agricultural products and livelihoods, Forestry Bureau made strategy for disaster prevention and reduction. Based on the strategy, Forestry Bureau sweeps away the driftwood by estimating its distribution, overcomes the issues caused by the heavy rainfall disaster, and helps the victims to recover their life

Home E-Cigarette Rules and Youth\u27s Vulnerability to Initiate and Sustain E-Cigarette Use

Existing studies of the impact of home rules on youth\u27s vulnerability to e-cigarette use were based on cross-sectional data, youth or parent reports alone, as well as youth\u27s perceptions and susceptibility. This study capitalizes on the restricted-use data of the Population Assessment of Tobacco and Health (PATH) Study to examine the longitudinal association between home rules for e-cigarette use and youth\u27s vulnerability including initiation of use and regular use two years later. Secondary analysis was conducted on 1203 parent-youth pairs who participated in both Wave 4 (2016-2018) and Wave 5 (2018-2019) assessment of the PATH Study and while the youth were age 12-16 at Wave 4. Linear and logistic regressions were performed to examine the associations between having a strict home rule for e-cigarette use at Wave 4 and the youth\u27s outcomes including perceived social norms, expectancies, susceptibility, initiation of use, and regular use of e-cigarettes at Wave 5, controlling for parent and youth factors. The results show that having a strict home rule for e-cigarette use was associated with youth\u27s heightened level of perceived injunctive norms (β = 0.22, p \u3c 0.01), higher expectancy of harmfulness (β = 0.28, p \u3c 0.01) and lower odds for regular e-cigarette use (OR = 0.36, p \u3c 0.05). In conclusion, the findings of this study support the potential protective effects of implementing a strict home rule for e-cigarette use. Future intervention efforts may promote parents\u27 awareness of the potential protective effects of a strict home e-cigarette rule on youth\u27s normative belief, harm expectancy, and behavior of e-cigarette use

Fusion of Diffusion Weighted MRI and Clinical Data for Predicting Functional Outcome after Acute Ischemic Stroke with Deep Contrastive Learning

Stroke is a common disabling neurological condition that affects about one-quarter of the adult population over age 25; more than half of patients still have poor outcomes, such as permanent functional dependence or even death, after the onset of acute stroke. The aim of this study is to investigate the efficacy of diffusion-weighted MRI modalities combining with structured health profile on predicting the functional outcome to facilitate early intervention. A deep fusion learning network is proposed with two-stage training: the first stage focuses on cross-modality representation learning and the second stage on classification. Supervised contrastive learning is exploited to learn discriminative features that separate the two classes of patients from embeddings of individual modalities and from the fused multimodal embedding. The network takes as the input DWI and ADC images, and structured health profile data. The outcome is the prediction of the patient needing long-term care at 3 months after the onset of stroke. Trained and evaluated with a dataset of 3297 patients, our proposed fusion model achieves 0.87, 0.80 and 80.45% for AUC, F1-score and accuracy, respectively, outperforming existing models that consolidate both imaging and structured data in the medical domain. If trained with comprehensive clinical variables, including NIHSS and comorbidities, the gain from images on making accurate prediction is not considered substantial, but significant. However, diffusion-weighted MRI can replace NIHSS to achieve comparable level of accuracy combining with other readily available clinical variables for better generalization.Comment: 12 pages, 5 figures, 5 table

Home E-Cigarette Rules and Youth\u27s Vulnerability to initiate and Sustain E-Cigarette Use

Existing studies of the impact of home rules on youth\u27s vulnerability to e-cigarette use were based on cross-sectional data, youth or parent reports alone, as well as youth\u27s perceptions and susceptibility. This study capitalizes on the restricted-use data of the Population Assessment of tobacco and Health (PATH) Study to examine the longitudinal association between home rules for e-cigarette use and youth\u27s vulnerability including initiation of use and regular use two years later. Secondary analysis was conducted on 1203 parent-youth pairs who participated in both Wave 4 (2016-2018) and Wave 5 (2018-2019) assessment of the PATH Study and while the youth were age 12-16 at Wave 4. Linear and logistic regressions were performed to examine the associations between having a strict home rule for e-cigarette use at Wave 4 and the youth\u27s outcomes including perceived social norms, expectancies, susceptibility, initiation of use, and regular use of e-cigarettes at Wave 5, controlling for parent and youth factors. The results show that having a strict home rule for e-cigarette use was associated with youth\u27s heightened level of perceived injunctive norms (β = 0.22, p \u3c 0.01), higher expectancy of harmfulness (β = 0.28, p \u3c 0.01) and lower odds for regular e-cigarette use (OR = 0.36, p \u3c 0.05). In conclusion, the findings of this study support the potential protective effects of implementing a strict home rule for e-cigarette use. Future intervention efforts may promote parents\u27 awareness of the potential protective effects of a strict home e-cigarette rule on youth\u27s normative belief, harm expectancy, and behavior of e-cigarette use

Void Structures in Regularly Patterned ZnO Nanorods Grown with the Hydrothermal Method

The void structures and related optical properties after thermal annealing with ambient oxygen in regularly patterned ZnO nanrorod (NR) arrays grown with the hydrothermal method are studied. In increasing the thermal annealing temperature, void distribution starts from the bottom and extends to the top of an NR in the vertical (c-axis) growth region. When the annealing temperature is higher than 400°C, void distribution spreads into the lateral (m-axis) growth region. Photoluminescence measurement shows that the ZnO band-edge emission, in contrast to defect emission in the yellow-red range, is the strongest under the n-ZnO NR process conditions of 0.003 M in Ga-doping concentration and 300°C in thermal annealing temperature with ambient oxygen. Energy dispersive X-ray spectroscopy data indicate that the concentration of hydroxyl groups in the vertical growth region is significantly higher than that in the lateral growth region. During thermal annealing, hydroxyl groups are desorbed from the NR leaving anion vacancies for reacting with cation vacancies to form voids

Novel Ultrasonographic Fatty Liver Indicator Can Predict Hepatitis in Children With Non-alcoholic Fatty Liver Disease

Background: Childhood non-alcoholic fatty liver disease (NAFLD) is a public health issue worldwide. To date, liver biopsy remains the gold standard for diagnosing the severity of NAFLD. However, this invasive procedure might contribute to complications. Owing to this reason, a good non-invasive tool to estimate NAFLD in children is urgently needed. We sought to investigate whether a non-invasive semi-quantitative ultrasonographic fatty liver indicator (US-FLI) can estimate NAFLD in children.Methods: Children aged between 10 and 18 years were enrolled prospectively. Abdominal ultrasonography was performed by a single experienced pediatric gastroenterologist and the non-invasive semi-quantitative US-FLI score were used. Patients were diagnosed with NAFLD if they had a US-FLI score ≥2. The anthropometric measures, obesity-related biochemical results, and levels of tumor necrosis factor-α, interleukin-6, caspase-cleaved cytokeratin fragment of cytokeratin 18 (M30), and adiponectin were also checked.Results: Overall, 117 children aged 10–18 years were enrolled. The anthropometric measures and obesity-related biochemical parameters (hsCRP, triglyceride, uric acid, AST, ALT, γ-GT, homeostatic model assessment insulin resistance (HOMA-IR), and M30) were significantly higher in the obesity group than in the non-obesity group (p < 0.05). Similarly, the US-FLI score was significantly higher in the obesity group than that in the non-obesity group (p < 0.001). Multiple linear regression showed that the US-FLI score was significantly associated with the waist-to-height ratio, uric acid, adiponectin, and M30 levels (all p < 0.05) in children with obesity. The US-FLI score ≥6 was the optimal cut-off point for predicting the hepatitis in children with NAFLD. The area under the receiver operating characteristic curve was 0.710 (95% CI: 0.572–0.847; p = 0.005).Conclusions: The non-invasive US-FLI score can predict hepatitis in children with NAFLD without mandatory liver biopsy. Moreover, the waist-to-height ratio, uric acid, adiponectin, and M30 levels were significantly associated with US-FLI score in children with obesity

Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response

<p>Abstract</p> <p>Background</p> <p>1-{4-[Bis(2-chloroethyl)amino]phenyl}-3-[2-methyl-5-(4-methylacridin-9-ylamino)phenyl]urea (BO-1051) is an N-mustard DNA alkylating agent reported to exhibit antitumor activity. Here we further investigate the effects of this compound on radiation responses of human gliomas, which are notorious for the high resistance to radiotherapy.</p> <p>Methods</p> <p>The clonogenic assay was used to determine the IC₅₀and radiosensitivity of human glioma cell lines (U87MG, U251MG and GBM-3) following BO-1051. DNA histogram and propidium iodide-Annexin V staining were used to determine the cell cycle distribution and the apoptosis, respectively. DNA damage and repair state were determined by γ-H2AX foci, and mitotic catastrophe was measure using nuclear fragmentation. Xenograft tumors were measured with a caliper, and the survival rate was determined using Kaplan-Meier method.</p> <p>Results</p> <p>BO-1051 inhibited growth of human gliomas in a dose- and time-dependent manner. Using the dosage at IC₅₀, BO-1051 significantly enhanced radiosensitivity to different extents [The sensitizer enhancement ratio was between 1.24 and 1.50 at 10% of survival fraction]. The radiosensitive G₂/M population was raised by BO-1051, whereas apoptosis and mitotic catastrophe were not affected. γ-H2AX foci was greatly increased and sustained by combined BO-1051 and γ-rays, suggested that DNA damage or repair capacity was impaired during treatment. <it>In vivo </it>studies further demonstrated that BO-1051 enhanced the radiotherapeutic effects on GBM-3-beared xenograft tumors, by which the sensitizer enhancement ratio was 1.97. The survival rate of treated mice was also increased accordingly.</p> <p>Conclusions</p> <p>These results indicate that BO-1051 can effectively enhance glioma cell radiosensitivity <it>in vitro </it>and <it>in vivo</it>. It suggests that BO-1051 is a potent radiosensitizer for treating human glioma cells.</p