Vaccine Innovation and Adoption: Polio Vaccines in the UK, the Netherlands and West Germany, 1955–1965

Lindner U, Blume S. Vaccine Innovation and Adoption. Polio Vaccines in the UK, the Netherlands and West Germany 1955-1965. Medical History. 2006;(50):425-446

The future of vaccine techno-politics: outcomes and lessons of the covid-19 pandemic

This proposal follows up the new book Immunization and States: The Politics of Making Vaccines, on which the conveners collaborated. The book focuses on public sector vaccine production in different countries from the nineteenth century onward. It ends with a brief sketch of the discussions and re-considerations provoked by two years of the Covid-19 pandemic. As the first effective Covid- 19 vaccines became available, intense disputes and negotiations arose over monopolies on vaccine production and access to vaccine technologies, unequal global distribution of vaccines, and seemingly widespread distrust of new vaccines

A Thermodynamic Model for Receptor Clustering

Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affects the signal transduction. Recent investigations have revealed the molecular basis of receptor-receptor interactions, but a simple theoretical framework for using this data to predict cluster formation has been lacking. Here, we propose a simple, coarse-grained, phenomenological model for ligand-modulated receptor interactions and discuss its equilibrium properties via mean-field theory. The existence of a first-order transition for this model has immediate implications regarding the robustness of the cellular signaling response.Comment: Biophysical Journal, to appea

TID compared to BID mycophenolate mofetil (MMF) improves donor chimerism and engraftment rates without increasing postgrafting toxicities after unrelated peripheral blood stem cell (PBSC) transplantation (HCT) with nonmyeloablative conditioning

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Treatment of patients (pts) with chemotherapy-refractory chronic lymphocytic leukemia (CLL) with nonmyeloablative (NM) conditioning and hematopoietic cell transplantation (HCT) from HLA-matched related (MRD) or unrelated donors (URD)

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