3,909 research outputs found

    ‘My friends made all the difference’: getting into and succeeding at university for first-time entrants

    Get PDF
    This paper reports on research findings from first-generation entrants at university in the UK. It examines their reasons for taking on higher-level study and what enables them to succeed. It points out that the phrase ‘first-generation entrants’ has been used interchangeably with the term ‘working-class students’ when there is not always a direct relationship between the two. Drawing on life history methods to gather the data, the paper examines the different experiences of working- and middle-class students and highlights the role of friendship as a key determinant in deciding to study in HE as well as in creating student success once at university. The article argues that friendships should be seen as a form of social capital (Bourdieu, 1984; Coleman, 1994; and Field, 2005) which can operate to militate against the effects of middle-class cultural and economic capital but can also be seen, in certain circumstances, to cement taken-for-granted practices

    The impact of social identity and cultural capital on different ethnic student groups at university

    Get PDF
    This research examines the experience of students from different student groups in higher education in Britain, asking the following questions: Is there any effect of different ‘University Cultures’ on students’ experience of higher education? How do different groups of students understand the concept of ‘belonging’ and ‘identity’ within a University? Do different student groups have different expectations and experiences of higher education? The research will draw on a range of social theories such as Social Capital, Cosmopolitanisation, Identity and Belonging and Mobility, assessing their relevance to the experience of different ethnic students in higher education (HE). Three HE institutions will participate in this project; a large comprehensive University, a campus based old University and a specialist college. A variety of quantitative and qualitative methods will be employed to maximise the breadth and depth of information gathered. Data collection will include a large scale questionnaire, focus groups and educational life history interviews with students from three differing institutions. Outcomes will inform the national debate about degree outcomes for different student groups and satisfaction levels between some student groups

    The Yeast Aac2 Protein Exists in Physical Association with the Cytochrome \u3cem\u3ebc\u3c/em\u3e\u3csub\u3e1\u3c/sub\u3e-COX Supercomplex and the TIM23 Machinery

    Get PDF
    The ADP/ATP carrier (AAC) proteins play a central role in cellular metabolism as they facilitate the exchange of ADP and ATP across the mitochondrial inner membrane. We present evidence here that in yeast (Saccharomyces cerevisiae) mitochondria the abundant Aac2 isoform exists in physical association with the cytochrome c reductase (cytochrome bc1)-cytochrome c oxidase (COX) supercomplex and its associated TIM23 machinery. Using a His-tagged Aac2 derivative and affinity purification studies, we also demonstrate here that the Aac2 isoform can be affinity-purified with other AAC proteins. Copurification of the Aac2 protein with the TIM23 machinery can occur independently of its association with the fully assembled cytochrome bc1-COX supercomplex. In the absence of the Aac2 protein, the assembly of the cytochrome bc1-COX supercomplex is perturbed, whereby a decrease in the III2-IV2 assembly state relative to the III2-IV form is observed. We propose that the association of the Aac2 protein with the cytochrome bc1-COX supercomplex is important for the function of the OXPHOS complexes and for the assembly of the COX complex. The physiological implications of the association of AAC with the cytochrome bc1-COX-TIM23 supercomplex are also discussed

    Oxa1 Directly Interacts with Atp9 and Mediates Its Assembly into the Mitochondrial F\u3csub\u3e1\u3c/sub\u3eF\u3csub\u3eo\u3c/sub\u3e-ATP Synthase Complex

    Get PDF
    The yeast Oxa1 protein is involved in the biogenesis of the mitochondrial oxidative phosphorylation (OXPHOS) machinery. The involvement of Oxa1 in the assembly of the cytochrome oxidase (COX) complex, where it facilitates the cotranslational membrane insertion of mitochondrially encoded COX subunits, is well documented. In this study we have addressed the role of Oxa1, and its sequence-related protein Cox18/Oxa2, in the biogenesis of the F1Fo-ATP synthase complex. We demonstrate that Oxa1, but not Cox18/Oxa2, directly supports the assembly of the membrane embedded Fo-sector of the ATP synthase. Oxa1 was found to physically interact with newly synthesized mitochondrially encoded Atp9 protein in a posttranslational manner and in a manner that is not dependent on the C-terminal, matrix-localized region of Oxa1. The stable manner of the Atp9-Oxa1 interaction is in contrast to the cotranslational and transient interaction previously observed for the mitochondrially encoded COX subunits with Oxa1. In the absence of Oxa1, Atp9 was observed to assemble into an oligomeric complex containing F1-subunits, but its further assembly with subunit 6 (Atp6) of the Fo-sector was perturbed. We propose that by directly interacting with newly synthesized Atp9 in a posttranslational manner, Oxa1 is required to maintain the assembly competence of the Atp9-F1-subcomplex for its association with Atp6

    Art and Social Change: AIDS Activism in Philadelphia

    Get PDF
    This study examines the social and political aspects of the AIDS epidemic through the lens of local arts and culture in the city of Philadelphia, asking these questions: What are the social roles of arts production and cultural activities arising in response to the AIDS epidemic? Are the categories of AIDS politics, such as treatment activism and prevention activism, or distinctions among infected populations reflected in cultural production? Is the concept of a “day without art” relevant only to those who count as artists and to their affluent patrons? How have the changing demographics of the epidemic affected AIDS related arts and culture? Does art work to communicate to the public information about the AIDS epidemic? Can art mobilize people and institutions for social change? As the study site, Philadelphia provides an opportunity to extend a social and cultural analysis of the AIDS epidemic to an urban area other than New York or San Francisco. And, while Philadelphia’s proximity to New York City affects all aspects of its relation to the AIDS epidemic (and to its entire arts and cultural scene), AIDS-related activism and culture are embedded in the city’s own history and politics and are certainly worthy of study on their own terms

    Unit organization of the topic jazz in the senior high school.

    Full text link
    Thesis (Ed.M.)--Boston Universit
    • 

    corecore