CH 750 / MW 745 Methodism in Europe: 19th and 20th century

1. McLeod, Hugh, Religion and the People of Western Europe 1789-1989. Oxford University Press, 1997 (second edition) (150 pages) 2. Kimbrough, S T Jr., Methodism in Russia and the Baltic States. History and Renewal. Abingdon Press, Nashville 1995 (250 pages) 3. Garber, Paul Neff, The Methodists of Continental Europe. Editorial Department, Board of Missions and Church Extension, The Methodist Church, New York, 1949. (125 pages) 4. Wunderlich, Friedrich, Methodists linking two Continents. Methodist Publishing House Nashville, 1960 (ca 170 pages) Total: 700 pages 5. For additional reading requirements (500 pages) according to personal choice see below under “course reading – recommended”.https://place.asburyseminary.edu/syllabi/2250/thumbnail.jp

Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm

Background: Polyamine metabolism has a critical role in cell death and proliferation representing a potential target for intervention in breast cancer (BC). This study investigates the expression of spermine oxidase (SMO) and its prognostic significance in BC. Biochemical analysis of Spm analogues BENSpm and CPENSpm, utilized in anticancer therapy, was also carried out to test their property in silico and in vitro on the recombinant SMO enzyme. Methods: BC tissue samples were analyzed for SMO transcript level and SMO activity. Student’s t test was applied to evaluate the significance of the differences in value observed in T and NT samples. The structure modeling analysis of BENSpm and CPENSpm complexes formed with the SMO enzyme and their inhibitory activity, assayed by in vitro experiments, were examined. Results: Both the expression level of SMO mRNA and SMO enzyme activity were significantly lower in BC samples compared to NT samples. The modeling of BENSpm and CPENSpm complexes formed with SMO and their inhibition properties showed that both were good inhibitors. Conclusions: This study shows that underexpression of SMO is a negative marker in BC. The SMO induction is a remarkable chemotherapeutical target. The BENSpm and CPENSpm are efficient SMO inhibitors. The inhibition properties shown by these analogues could explain their poor positive outcomes in Phases I and II of clinical trials

Les politiques de l'immigration

Photograph taken by Salt Lake Tribune staf