The results of the treatment of various morphological types of ENT skin cancer by photodynamic therapy

This article discusses one of the urgent problems of modern oncology — the question of treatment of skin cancer (SC). The experience of the new promising method of photodynamic therapy (PDT) in the treatment of patients with primary and recurrent skin cancer. Aim: to evaluate the effectiveness of photodynamic therapy (PDT) in the treatment of patients with primary and recurrent skin cancer (SC). Materials. The Main Military Clinical Hospital SC treatment of upper respiratory tract with PDT performed 108 patients: 85 men, 23 women. The age of patients ranged from 43 to 92 years, averaging 71 years. 96 patients were with basal cell skin cancer (BCC) in otolaryngology 8 patients were with squamous cell carcinoma of the skin (SCSC), 4 persons — with metatipichesky skin cancer (MSC). Results. In the treatment of patients with SC otolaryngology, PDT complete resorption (CR) was 89.8%, the partial resorption (PR) — 9.3%, no effect (NE) — 0.9%. The highest efficiency was obtained in the treatment method of PDT in patients with BCC otolaryngology — 92.7%. The least effective method of PDT in the treatment of upper respiratory tract SCSC — 62.5%. Disease-free outcome was noted in 88.7% of patients SC otolaryngology. In 11.3% of cases, relapse. The highest efficiency was obtained in the treatment method of PDT in patients with BCC otolaryngology — 89.9%. The least effective method of PDT in the treatment of upper respiratory tract MSC — 66.7%. Conclusion. PDT is an effective treatment RK ENT, unlike other methods of treatment of organ-character, excellent cosmetic and functional results, high selectivity of therapeutic action, the absence of severe systemic effects on the body. The advantage of PDT compared with other treatments SC ENT is also the possibility of multiple repeating the procedure in the case of large diameter and in multiple tumor malignancy without risk of complications

Outlooks of photodynamic therapy for the treatment of cervical diseases in routine clinical practice

Cervical cancer is one of the most common malignancies. Despite the existence of well-developed classical approaches to prevention, diagnosis, and treatment, cervical cancer demonstrates one of the highest incidence and mortality rates among female cancers. Cervical diseases are widespread, can develop at any age, and often preceded cancer development. Photodynamic therapy (PDT) is a new and unique treatment for cancer and a number of non-malignant diseases, which is based on systemic or topical administration of photosensitizers, followed by laser exposure. We analyzed foreign and Russian articles published between 2004 and 2018 evaluating the efficacy of PDT in patients with precancerous diseases and early cervical cancer. PDT is a highly effective treatment method, which causes no complications and can eliminate human papilloma virus. We assessed potential outlooks of wide clinical use of PDT. © 2020, Dynasty Publishing House. All rights reserved