11 research outputs found
Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.
- Author
- Aguado-Barrera ME
- Ahsen ME
- Baran A
- Barnett GC
- Bentzen SM
- Burnet NG
- Carballo AM
- Dearnaley DP
- DeRuyck K
- Dorling L
- Dunning AM
- Eeles R
- Elliott RM
- Fachal L
- Gulliford SL
- Gómez-Caamaño A
- Hall E
- Hao K
- Hollenberg M
- Imai T
- Janelsins M
- Kerns SL
- Lobato-Busto R
- Narzo AD
- Ostrer H
- Pandey G
- Parliament M
- Peleteiro P
- Peterson DR
- Pharoah PDP
- Rosenstein BS
- Saito S
- Singhal S
- Stock R
- Stone NN
- Sydes MR
- Tsuji H
- Usmani N
- Vega A
- West CML
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/02/2020
- Field of study
Background A total of 10%-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies.Methods We conducted an individual patient data meta-analysis of six genome-wide association studies (nâ=â3871) in men of European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequency, decreased urinary stream, hematuria, rectal bleeding) were graded prospectively. We used grouped relative risk models to test associations with approximately 6 million genotyped or imputed variants (time to first grade 2 or higher toxicity event). Variants with two-sided Pmeta less than 5 Ă 10-8 were considered statistically significant. Bayesian false discovery probability provided an additional measure of confidence. Statistically significant variants were evaluated in three Japanese cohorts (nâ=â962). All statistical tests were two-sided.Results Meta-analysis of the European ancestry cohorts identified three genomic signals: single nucleotide polymorphism rs17055178 with rectal bleeding (Pmeta = 6.2 Ă 10-10), rs10969913 with decreased urinary stream (Pmeta = 2.9 Ă 10-10), and rs11122573 with hematuria (Pmeta = 1.8 Ă 10-8). Fine-scale mapping of these three regions was used to identify another independent signal (rs147121532) associated with hematuria (Pconditional = 4.7 Ă 10-6). Credible causal variants at these four signals lie in gene-regulatory regions, some modulating expression of nearby genes. Previously identified variants showed consistent associations (rs17599026 with increased urinary frequency, rs7720298 with decreased urinary stream, rs1801516 with overall toxicity) in new cohorts. rs10969913 and rs17599026 had similar effects in the photon-treated Japanese cohorts.Conclusions This study increases the understanding of the architecture of common genetic variants affecting radiotoxicity, points to novel radio-pathogenic mechanisms, and develops risk models for testing in clinical studies. Further multinational radiogenomics studies in larger cohorts are worthwhile
Permanent seed implantation for localized adenocarcinoma of the prostate
- Author
- A Jemal
- AS Meigooni
- CC Ling
- DP Fontenla
- EM Tapen
- FA Critz
- GS Lederman
- H Ragde
- H Ragde
- HH Holm
- J Desai
- JC Blasko
- JC Blasko
- JC Blasko
- K Wallner
- KM Snyder
- KW Kaye
- L Kleinberg
- LL Anderson
- LN Lee
- M Dattoli
- MD Terk
- MJ Dattoli
- Nelson N. Stone
- NN Stone
- NN Stone
- NN Stone
- NN Stone
- NN Stone
- NN Stone
- O Pasteau
- PD Grimm
- PLM Vijverberg
- R Nath
- R Paterson
- RG Stock
- RG Stock
- RG Stock
- RG Stock
- RG Stock
- RH Flocks
- Richard G. Stock
- S Chiu-Tsao
- S Nag
- SI Zeitlin
- WF Whitmore
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Radiation Treatment Planning for Prostate Brachytherapy
- Author
- Publication venue
- 'Japanese Society of Radiological Technology'
- Publication date
- 01/01/2009
- Field of study
Combining theoretical potential and advanced technology in high-dose rate brachytherapy boost therapy for prostate cancer
- Author
- Abramowitz MC
- Adam P Dicker
- Akimoto T
- Borghede G
- Buyyounouski MK
- Cahlon O
- Dearnaley DP
- Demanes DJ
- Demanes DJ
- Demanes DJ
- Duchesne GM
- Eddy H A.
- Fowler J
- Fowler JF
- Galalae RM
- Galalae RM
- Gelblum DY
- Grimm P
- Herrmann MK
- Hinnen KA
- Holly R
- Holmboe ES
- Hoskin PJ
- Hsu IC
- Hurwitz M.
- Hurwitz MD
- Hurwitz MD
- Hurwitz MD.
- Kalkner KM
- Kestin LL
- Keyes M
- Khor R
- Kleinmann N
- Kovacs G
- Kovalchuk N
- Kuban DA
- Laura A Doyle
- Lee WR
- Luo HL
- Maluta S
- Mark D Hurwitz
- Martinez A
- Martinez AA
- Martinez-Monge R
- Moher D
- Morton G
- Morton GC.
- Myers MA Hagan M P
- Nicholas G Zaorsky
- Pickles T
- Pisansky TM
- Potters L
- Robert B Den
- Sanda MG
- Shen X
- Siegel R
- Song C W.
- Stone NN
- Stone NN Stock R G
- Sumida I
- Taira AV
- Tang JI
- Van Vulpen M
- Vargas CE
- Wang JZ
- Whitaker M
- Yamada Y
- Yoshioka Y
- Yoshioka Y.
- Zaorsky NG
- Zaorsky NG
- Zaorsky NG
- Zaorsky NG
- Zelefsky M
- Zelefsky MJ
- Zelefsky MJ
- Zietman A
- Zietman AL
- Zietman AL
- Zwahlen DR
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Tumor burden and location as prognostic factors in patients treated by iodine seed implant brachytherapy for localized prostate cancers
- Author
- A Adamy
- A Grann
- A Heidenreich
- AL Zietman
- Andres Huertas
- Arnaud MĂ©jean
- AV DâAmico
- AV DâAmico
- AV DâAmico
- AV Taira
- BJ Davis
- C Giberti
- CA Lawton
- Charles Dariane
- Claire Meynard
- D Ash
- D Liu
- FC Hamdy
- G Rodrigues
- GS Merrick
- GS Merrick
- GS Merrick
- GS Merrick
- I Spadinger
- J Hill
- J-M Cosset
- JA Kittel
- JC Blasko
- JE Sylvester
- JJ Tosoian
- JM Crook
- JM Michalski
- JM Samuelian
- K Martell
- K Wallner
- L Klotz
- L Potters
- M Graefen
- M Keyes
- M Pinkawa
- M Roach
- MA Kollmeier
- Marc-Olivier Timsit
- MJ Zelefsky
- MJ Zelefsky
- ML McHugh
- ML Wills
- MR Cupp
- N Bittner
- N Mottet
- Nicolas Thiounn
- NJ Nasser
- NN Stone
- NN Stone
- O Ogawa
- PA Kupelian
- PA Peller
- PD Grimm
- Philippe Giraud
- PJ Rossi
- Quentin Dubourg
- R Nurani
- RA Badalament
- RG Stock
- S Lazarev
- S Nath
- S Sidhu
- Saik Urien
- Sandra Toublanc
- SJ Frank
- TJ Guzzo
- TJ Sebo
- TM Therneau
- WD Heemsbergen
- WJ Ellis
- ZS Zumsteg
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Permanent Seed Implantation
- Author
- A Kaplan
- A Sidana
- A Sugawara
- A Sugawara
- A Thompson
- A Toledano
- AC Reese
- AJ Stephenson
- AK Leventis
- AN Ivanowicz
- AV DâAmico
- AV Taira
- AV Taira
- AX Zhu
- B Pickett
- B Pickett
- B Ryu
- BD Nguyen
- BJ Davis
- BJ Davis
- C Chiumento
- C Herbert
- C Patel
- C Salembier
- CA Lawton
- CM Fisher
- CM Hoeks
- CR Loiselle
- CW Thomas
- D Ash
- D Ash
- D Bowes
- D Bowes
- D Bowes
- D Petrik
- D Taussky
- DC Beyer
- DP Nguyen
- DS Stember
- E Fur Le
- EC Ko
- EF Miles
- EK Hansen
- EK Hau
- EM Roeloffzen
- EM Roeloffzen
- EP Saibishkumar
- F Gomez-Veiga
- FM Waterman
- G Delouya
- G Roberts
- G Rodrigues
- GN Cohen
- GS Merrick
- GS Merrick
- GS Merrick
- GS Merrick
- GS Merrick
- GS Merrick
- GS Merrick
- GS Merrick
- H Quon
- HJ Lavery
- HK Lee
- HO Badwan
- Horwich A Parker C, Bangma C, Kataja V, Group EGW
- HW Liu
- I Thompson
- J Crook
- J Crook
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- J Huang
- J Mayadev
- JA Eastham
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- JC Blasko
- JE Sylvester
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- K Harada
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- KA Hinnen
- KA Hinnen
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- KL Maletz
- KS Choe
- L Hughes
- LC Fang
- LG Marcu
- LK McNeely
- LN Lee
- M Beasley
- M Brabandere De
- M Caloglu
- M Gaztañaga
- M Keyes
- M Keyes
- M Keyes
- M Paoluzzi
- M Peters
- M Pinkawa
- M Roach 3rd
- M Schmedders
- M Shilkrut
- MH Katz
- MJ Zelefsky
- MJ Zelefsky
- MJ Zelefsky
- MJ Zelefsky
- N Bittner
- N Bittner
- N Tanaka
- N Tanaka
- N Tanaka
- NL Dallas
- NN Stone
- NN Stone
- NN Stone
- O Alenda
- P Orio
- R Mazeron
- R Mazeron
- R Stock
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- RJ Kudchadker
- S Beriwal
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- SE Langley
- SG Williams
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- SJ Frank
- SL Liauw
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- T Ohashi
- T Uesugi
- TL McElveen
- Turley RS Terris MK, Kane CJ, Aronson WJ, Presti JC, Jr., Amling CL, Freedland SJ, Group SDS
- U Mahmood
- V Narayana
- W Ding
- W Wagner
- W Wagner
- WC Chen
- X Shen
- Y Kono
- Y Naya
- ZA Allen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Computer Processing of Line-Drawing Images
- Author
- ADAMOWICZ M
- ARCELLI C.
- ARMIT A P
- ATTNEAVE F.
- BENGTSSON B E
- BOTTING R. J
- BRESENHAM J. E
- BURKHALTER R.
- B~ECKER R M
- CANTONI A.
- CAPON J
- CE C. R
- CHANG S.
- CHLRRY C.
- CHRISTENSEN C
- DHU G S
- DINNEEN G.
- DVDA R. O.
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- ENCARNACAO J
- EVANS D.
- FAIMAN M
- FEDER
- FEDER J.
- FEDER J.
- FIRSCHEIN O.
- FIRSCHEIN O.
- FORREST A R
- FREEMAN A
- FREEMAN H
- FREEMAN H.
- FREEMAN H.
- FREEMAN H.
- FREEMAN H.
- FREEMAN H.
- FREEMAN H.
- FREEMAN On
- FRF~EMAN H
- GILMORE P C
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- GRAHAM D. N.
- GRAY S. B
- GREANIAS E. C
- GREANIAS E. C.
- GRIMSDALE R L
- GRONER G. F.
- GROSS M.
- GUZMAN
- GUZMAN A.
- HAIMS M J
- HARLOW D. A.
- Herbert Freeman
- HILDITCH A
- HODES L
- HOLDERMANN F
- HUFFM N D
- I~OSENFELD A
- JARVIS C. L
- KNOWLTON A
- KNOWLTON K
- LEEUWENBERG E. L.
- LEVI G
- LIPKIN B
- LIPKIN L.
- LOEB
- LOUTREL P.
- MACH I~ E
- MARTELLI
- MAXWELL P C
- MILLER W
- NAGAO
- NARASIMHAN R
- NEWMAN W M
- PA GF~
- PALMER A B
- PARKS J. R
- PINGLE K K
- PI~TEWAY M L
- PREW TT
- PRINCE M. D.
- RABX~OWITZ A.
- RAMER U.
- REGGIORI
- ROSENBFRG B
- ROSENFELD A
- ROSENFELD A
- SAKAI T
- SCH In~
- SCHW NN
- SELFRIDGE
- SHERM N
- STALLINGS W.
- STOCK~IAM
- STONE S P
- SUTHJ' LAND
- S~KA~ T.
- TAKASAWA Y
- TIPPITT J.
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- TRIENDL E E
- UNGER S H
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- WHOLEV J S
- WILI~IAMS R.
- WINSTON J. S.
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- W~TTS T L
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- ~TSON W. L
- Publication venue
- 'Association for Computing Machinery (ACM)'
- Publication date
- Field of study
The Hammett Equationâthe Present Position
- Author
- A Benko
- A Bryson
- A Bryson
- A Bryson
- A Bryson
- A Bryson
- A Fischer
- A Fischer
- A Hald
- A Kucsman
- A Reiker
- A Reiser
- A Ricci
- A Streitwieser
- A Talvik
- A. V. Willi
- AB Thigpen
- AJ Ellis
- AK Colter
- AP Serjeant
- AR Fersht
- AR Iher
- AR Katritzky
- AV Willi
- AV Willi
- AV Willi
- AV Willi
- AV Willi
- AV Willi
- AZ Pihl
- B. J. Lindberg
- BA Porai-Koshits
- BJ Lindberg
- BJ Lindberg
- BM Anderson
- C Eaborn
- C Sandorfy
- C Tanford
- C Walling
- C-R Guérillot
- C-R Guérillot
- C-R Guérillot
- C-R Guérillot
- C. L. Ligny
- C. W. Donaldson
- CC Price
- CC Price
- CC Price
- CC Price
- CC Price
- CD Ritchie
- CD Ritchie
- CD Ritchie
- CD Ritchie
- CD Ritchie
- CF Wilcox
- CF Wilcox
- CG Swain
- CG Swain
- CG Swain
- CG Swain
- CH Bamford
- CH Puy
- CJ Lancelot
- CJ Lancelot
- CK Hancock
- CK Hancock
- CK Hancock
- CK Hancock
- CK Hancock
- CK Hancock
- CL Habraken
- CM Judson
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- CS Hahn
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- D. H. McDaniel
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- DE Pickart
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- WA Sheppard
- WA Sheppard
- WA Sheppard
- WF Little
- WF Little
- WF Little
- WF Little
- WH Saunders
- WK Kwok
- WM Schubert
- WN White
- WP Jencks
- WT Miller
- Y Kondo
- Y Ogata
- Y Ogata
- Y Ogata
- Y Okamoto
- Y Okamoto
- Y Okamoto
- Y Okamoto
- Y Otsuji
- Y Otsuji
- Y Otsuji
- Y Tsuno
- Y Yukawa
- Y Yukawa
- Y Yukawa
- YA Zhdanov
- Yu. A. Zhdanov
- Ă. L. Haldna
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1972
- Field of study
Management of High-Risk/Locally Advanced Disease
- Author
- A Briganti
- A Merglen
- A Pollack
- A Tewari
- AA Martinez
- AL Moore
- AL Zietman
- AM Hovels
- AV DâAmico
- AV DâAmico
- AW Levinson
- B Engels
- BS Carver
- C Cozzarini
- C Cozzarini
- C Parker
- CA Lawton
- CA Lawton
- CA Lawton
- CA Lawton
- CC Schulman
- CE Vargas
- CR King
- CY Hsu
- CY Hsu
- D Pucar
- D Schreiber
- D Villari
- DP Dearnaley
- DP Dearnaley
- E Sacco
- EM Messing
- FM Fang
- G Arcangeli
- G Aus
- GA Viani
- GA Viani
- GE Hanks
- GK Zagars
- GP Murphy
- GS Merrick
- IM Thompson
- JB Ashman
- JB Yu
- JB Yu
- JE Sylvester
- JF Ward
- JJ Coen
- JL Mohler
- JR Sathya
- K Akakura
- L Cheng
- LF Pozzo Da
- LH Klotz
- LL Kestin
- LP Muren
- M Bolla
- M Bolla
- M Bolla
- M Roach 3rd
- MD Shelley
- MG Harisinghani
- MJ Zelefsky
- MJ Zelefsky
- MJ Zelefsky
- MJ Zelefsky
- MJ Zelefsky
- MR Cooperberg
- MR Cooperberg
- MS Anscher
- MS Anscher
- MV Pilepich
- MV Pilepich
- N Cellini
- NN Stone
- O Cahlon
- P Bader
- P Diez
- P Nickers
- P Ost
- P Pommier
- PA Kupelian
- PB Morgan
- PL Nguyen
- PL Nguyen
- PM Pierorazio
- R Jacob
- R Schiavina
- RG Stock
- RK Berglund
- RM Galalae
- RV Chandra
- S Daneshmand
- S Loeb
- SA Boorjian
- SA Boorjian
- SA Joslyn
- SA Rosenthal
- SA Vora
- SG Fletcher
- SR Bott
- ST Peeters
- T Wiegel
- TA Masterson
- TJ Robnett
- TN Eade
- V Fonteyne
- V Pagliarulo
- WR Parker
- Y Yamada
- Y Yoshioka
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- U Bagge
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1988
- Field of study