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Association of nutritional abnormalities and immune parameters in HIV-1 seronegative homosexual men
Nutritional parameters and immune function in HIV-1 seronegative, homosexual males (n = 42) were evaluated in order to provide comparison data for investigation of the role of nutrition in HIV-1 infection. Our findings indicate that a high proportion of the homosexual HIV-1 seronegative men (70%) in this study, exhibited at least one nutritional abnormality, with 26% showing multiple aberrations. The majority of men demonstrated inadequate riboflavin status, and low levels of plasma copper. Blood levels of vitamin B sub(6) and zinc were decreased in a smaller proportion of the population. The following interactions between nutrients and immune function in HIV-1 seronegative homosexual males were documented: low plasma zinc was associated with decreased CD4 cell number, mitogen responsiveness and natural killer (NK) cell cytotoxicity; impaired vitamin B sub(6) status was related to decreased mitogen responsiveness; low plasma copper was associated with a significantly increased CD4 cell number, and individuals with two or more specific nutrient abnormalities had decreased mitogen responsiveness and NK cell cytotoxicity, when compared to HIV-1 seronegative subjects with adequate nutritional status