Sesquicaesium hemisodium tetra­cyanidoplatinate(II) sesquihydrate

The title compound, Cs1.5Na0.5[Pt(CN)4]·1.5H2O, was isolated from solution as a salt. The tetra­cyanidoplatinate (TCP) anions are stacked in a linear quasi-one-dimensional arrangement along the b axis, with Pt⋯Pt inter­actions of 3.6321 (5) Å. The mixed alkali metal TCP contains three distinct alkali metal positions in the structure that do not show any mixed occupancy: Cs1 (site symmetry 2), Cs2 (general position) and Na1 (site symmetry ). The Na+ ion contains an octa­hedral coordination environment composed of two water mol­ecules and four N-terminal cyanides, which serve to bridge TCP anions. The Cs+ cations contain mono- and bicapped square-prismatic environments, where the square prisms are formed from cyanide N atoms with water mol­ecules capping the faces. The 1.5 water mol­ecules per formula unit are a result of two fully occupied sites, one on a general position and one on a twofold rotation axis. Weak hydrogen-bonding inter­actions are observed between one water mol­ecule and terminal N-atom acceptors from TCP, while the second water mol­ecule is not involved in hydrogen bonding

catena-Poly[[[diaqua­(nitrato-κ2 O,O′)(2,2′:6′,2′′-terpyridine-κ3 N,N′,N′′)ytterbium(III)]-μ-cyanido-κ2 N:C-[dicyanido­platinum(II)]-μ-cyanido-κ2 C:N] acetonitrile monosolvate]

The title compound, {[PtYb(CN)4(NO3)(C15H11N3)(H2O)2]·CH3CN}n, was isolated from solution as a one-dimensional coordination polymer. The Yb3+ site has ninefold coordination with a distorted tricapped trigonal–prismatic geometry, while the PtII ion is coordinated by four cyanide groups in an almost regular square-planar geometry. cis-Bridging by the tetra­cyanidoplatinate(II) anions links the Yb3+ cations, forming chains. Additionally, each Yb3+ is coordinated by two water mol­ecules, one bidentate nitrate anion, and one tridentate 2,2′:6′,2′′-terpyridine mol­ecule. O—H⋯N hydrogen-bonding inter­actions are found between adjacent chains and help to consolidate the crystal packing. In addition, π–π stacking inter­actions exist between the terpyridine ligand and the two corresponding terpyridine ligands along the adjacent chain (average inter­planar distance = 3.667 Å). Moderate Pt⋯Pt inter­actions [3.5033 (4) Å] are observed in the structure

Chlorido{2-[(dimethyl­amino)­methyl]phenyl-κ2 C 1,N}(1-methyl-1H-imidazole-κN 3)palladium(II)

In the title compound, [Pd(C9H12N)Cl(C4H6N2)], which was synthesized from the reaction of 1-methyl­imidazole with dimeric dichloridobis[2-(dimethyl­amino)­benz­yl]palla­dium(II), the ring-deprotonated N,N-dimethyl­benzyl­amine ligand acts in a C,N-bidentate fashion. The dihedral angle between the ring of the 1-methyl­imidazole ligand and the palladacycle plane is 57.88 (16)°. The two N atoms from the N,N-dimethyl­benzyl­amine and 1-methyl­imidazole ligands are trans coordinated to the PdII atom

Electrodeposited hydroxyapatite thin films modified by ion beam irradiation

Surface modification of hydroxyapatite (HA) thin films electrodeposited on titanium was conducted by ion implantation, using nitrogen and argon ions at different constant fluences of 1x10(15), 1x10(16) and 1x10(17) ions/cm(2). SEM and XRD analysis, as well as SRIM calculation, were used to monitor the changes induced by ion bombardment. In the case of HA film implanted with N(4+) ions, the unit cell parameters and unit cell volume increase with increasing nitrogen ion fluences. Similarly, the unit cell parameters and unit cell volume increase after Ar(6+) ions irradiation to a 1x10(15) ions/cm(2). At higher fluences, the unit cell parameters and unit cell volume decrease when argon ion fluences increase to 1x10(16) and 1x10(17) ions/cm(2). These structural changes are consequence of different mechanism of energy transfer of nitrogen and argon ions to HA film. For nitrogen ion irradiation electron energy loss is predominant, while for argon ion irradiation nuclear energy transfer to HA film prevails

Intermittent theta burst stimulation attenuates oxidative stress and reactive astrogliosis in the streptozotocin-induced model of Alzheimer’s disease-like pathology

IntroductionIntracerebroventricularly (icv) injected streptozotocin (STZ) is a widely used model for sporadic Alzheimer’s disease (sAD)-like pathology, marked by oxidative stress-mediated pathological progression. Intermittent theta burst stimulation (iTBS) is a noninvasive technique for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for several neurological diseases, including AD. The present study aims to investigate the effect of the iTBS protocol on the animal model of STZ-induced sAD-like pathology in the context of antioxidant, anti-inflammatory, and anti-amyloidogenic effects in the cortex, striatum, hippocampus, and cerebellum.MethodsMale Wistar rats were divided into four experimental groups: control (icv normal saline solution), STZ (icv STZ—3 mg/kg), STZ + iTBS (STZ rats subjected to iTBS protocol), and STZ + Placebo (STZ animals subjected to placebo iTBS noise artifact). Biochemical assays and immunofluorescence microscopy were used to evaluate functional and structural changes.ResultsThe icv STZ administration induces oxidative stress and attenuates antioxidative capacity in all examined brain regions. iTBS treatment significantly reduced oxidative and nitrosative stress parameters. Also, iTBS decreased Aβ-1-42 and APP levels. The iTBS enhances antioxidative capacity reported as elevated activity of its enzymatic and non-enzymatic components. In addition, iTBS elevated BDNF expression and attenuated STZ-induced astrogliosis confirmed by decreased GFAP+/VIM+/C3+ cell reactivity in the hippocampus.DiscussionOur results provide experimental evidence for the beneficial effects of the applied iTBS protocol in attenuating oxidative stress, increasing antioxidant capacity and decreasing reactive astrogliosis in STZ-administrated rats

TOTAL HIP ARTHROPLASTY IN PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS – A REPORT ON TWO CASES

Rheumatoid arthritis is traditionally considered a chronic, inflammatory autoimmune disorder of unknown etiology.It is a disabling and painful inflammatory condition, which can lead to substantial loss of mobility due to pain and joint destruction. Clinical characteristics of the rheumatoid hip are pain, limited range of motion, and rapid onset of cartilage destruction resulting in secondary changes in other lower limb joints and the spine. Radiography showed intensive osteoporosis and later protrusion of acetabulum. Treatment of rheumatoid coxitis is specific, which depends on the stage of disease, subjective and objective complications, and can be medicamentous, functional and operative.The study presents the treatment of two patients with rheumatoid arthritis with total hip arthroplasty at the Clinic of Orthopaedics and Traumatology Clinical Center Nis. In a fifty-five-old patient with the diagnosis of rheumatoid arthritis, the rheumatoid hip joint underwent a cementless total hip arthroplasty. In a sixty-eight-year old patient, the rheumatoid hip joint underwent total hip arthroplasty with cement. In both patients we obtained good functional results.Total hip arthroplasty in patients with rheumatoid coxitis relieves pain and prevents invalidity conditioned by destruction of the hip joint