29 research outputs found

    MaRCoS, an open-source electronic control system for low-field MRI

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    Every magnetic resonance imaging (MRI) device requires an electronic control system that handles pulse sequences and signal detection and processing. Here we provide details on the architecture and performance of MaRCoS, a MAgnetic Resonance COntrol System developed by an open international community of low-field MRI researchers. MaRCoS is inexpensive and can handle cycle-accurate sequences without hard length limitations, rapid bursts of events, and arbitrary waveforms. It can also be easily adapted to meet further specifications required by the various academic and private institutions participating in its development. We describe the MaRCoS hardware, firmware and software that enable all of the above, including a Python-based graphical user interface for pulse sequence implementation, data processing and image reconstruction.Comment: 10 pages, 4 figure

    An eight‐channel Tx dipole and 20‐channel Rx loop coil array for MRI of the cervical spinal cord at 7 tesla

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    RÉSUMÉ: The quality of cervical spinal cord images can be improved by the use of tailored radiofrequency (RF) coil solutions for ultrahigh field imaging; however, very few commercial and research 7-T RF coils currently exist for the spinal cord, and in particular, those with parallel transmission (pTx) capabilities. This work presents the design, testing, and validation of a pTx/Rx coil for the human neck and cervical/upper thoracic spinal cord. The pTx portion is composed of eight dipoles to ensure high homogeneity over this large region of the spinal cord. The Rx portion is made up of twenty semiadaptable overlapping loops to produce high signal-to-noise ratio (SNR) across the patient population. The coil housing is designed to facilitate patient positioning and comfort, while also being tight fitting to ensure high sensitivity. We demonstrate RF shimming capabilities to optimize B1+ uniformity, power efficiency, and/or specific absorption rate efficiency. B1+ homogeneity, SNR, and g-factor were evaluated in adult volunteers and demonstrated excellent performance from the occipital lobe down to the T4-T5 level. We compared the proposed coil with two state-of-the-art head and head/neck coils, confirming its superiority in the cervical and upper thoracic regions of the spinal cord. This coil solution therefore provides a convincing platform for producing the high image quality necessary for clinical and research scanning of the upper spinal cord

    Dynamic distortion correction for functional MRI using FID navigators

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    Purpose To develop a method for slice-wise dynamic distortion correction for EPI using rapid spatiotemporal B(0)field measurements from FID navigators (FIDnavs) and to evaluate the efficacy of this new approach relative to an established data-driven technique. Methods A low-resolution reference image was used to create a forward model of FIDnav signal changes to enable estimation of spatiotemporal B(0)inhomogeneity variations up to second order from measured FIDnavs. Five volunteers were scanned at 3 T using a 64-channel coil with FID-navigated EPI. The accuracy of voxel shift measurements and geometric distortion correction was assessed for experimentally induced magnetic field perturbations. The temporal SNR was evaluated in EPI time-series acquired at rest and with a continuous nose-touching action, before and after image realignment. Results Field inhomogeneity coefficients and voxel shift maps measured using FIDnavs were in excellent agreement with multi-echo EPI measurements. The FID-navigated distortion correction accurately corrected image geometry in the presence of induced magnetic field perturbations, outperforming the data-driven approach in regions with large field offsets. In functional MRI scans with nose touching, FIDnav-based correction yielded temporal SNR gains of 30% in gray matter. Following image realignment, which accounted for global image shifts, temporal SNR gains of 3% were achieved. Conclusions Our proposed application of FIDnavs enables slice-wise dynamic distortion correction with high temporal efficiency. We achieved improved signal stability by leveraging the encoding information from multichannel coils. This approach can be easily adapted to other EPI-based sequences to improve temporal SNR for a variety of clinical and research applications

    Algebraic reconstruction technique for parallel imaging reconstruction of undersampled radial data: Application to cardiac cine

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    PURPOSE: To investigate algebraic reconstruction technique (ART) for parallel imaging reconstruction of radial data, applied to accelerated cardiac cine. METHODS: A GPU-accelerated ART reconstruction was implemented and applied to simulations, point spread functions (PSF) and in twelve subjects imaged with radial cardiac cine acquisitions. Cine images were reconstructed with radial ART at multiple undersampling levels (192 N(r) x N(p) = 96 to 16). Images were qualitatively and quantitatively analyzed for sharpness and artifacts, and compared to filtered back-projection (FBP), and conjugate gradient SENSE (CG SENSE). RESULTS: Radial ART provided reduced artifacts and mainly preserved spatial resolution, for both simulations and in vivo data. Artifacts were qualitatively and quantitatively less with ART than FBP using 48, 32, and 24 N(p), although FBP provided quantitatively sharper images at undersampling levels of 48-24 N(p) (all p<0.05). Use of undersampled radial data for generating auto-calibrated coil-sensitivity profiles resulted in slightly reduced quality. ART was comparable to CG SENSE. GPU-acceleration increased ART reconstruction speed 15-fold, with little impact on the images. CONCLUSION: GPU-accelerated ART is an alternative approach to image reconstruction for parallel radial MR imaging, providing reduced artifacts while mainly maintaining sharpness compared to FBP, as shown by its first application in cardiac studies

    A novel whole-head RF coil design tailored for concurrent multichannel brain stimulation and imaging at 3T

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    Purpose: Multichannel Transcranial Magnetic Stimulation (mTMS) [1] is a novel non-invasive brain stimulation technique allowing multiple sites to be stimulated simultaneously or sequentially under electronic control without movement of the coils. To enable simultaneous mTMS and MR imaging, we have designed and constructed a whole-head 28-channel receive-only RF coil at 3T. Methods: A helmet-shaped structure was designed considering a specific layout for a mTMS system with holes for positioning the TMS units next to the scalp. Diameter of the TMS units defined the diameter of RF loops. The placement of the preamplifiers was designed to minimize possible interactions and to allow straightforward positioning of the mTMS units around the RF coil. Interactions between TMS-MRI were analyzed for the whole-head system extending the results presented in previous publications [2]. Both SNR- and g-factors maps were obtained to compare the imaging performance of the coil with commercial head coils. Results: Sensitivity losses for the RF elements containing TMS units show a well-defined spatial pattern. Simulations indicate that the losses are predominantly caused by eddy currents on the coil wire windings. The average SNR performance of the TMSMR 28-channel coil is about 66% and 86% of the SNR of the 32/20-channel head coil respectively. The g-factor values of the TMSMR 28-channel coil are similar to the 32-channel coil and significantly better than the 20-channel coil. Conclusion: We present the TMSMR 28-channel coil, a head RF coil array to be integrated with a multichannel 3-axisTMS coil system, a novel tool that will enable causal mapping of human brain function

    Performance characterization of three coils for whole brain and/or cervical spinal cord MRI at 7T

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    An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T

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    © 2020, The Author(s). Metabolic imaging of the human brain by in-vivo magnetic resonance spectroscopic imaging (MRSI) can non-invasively probe neurochemistry in healthy and disease conditions. MRSI at ultra-high field (≄ 7 T) provides increased sensitivity for fast high-resolution metabolic imaging, but comes with technical challenges due to non-uniform B0 field. Here, we show that an integrated RF-receive/B0-shim (AC/DC) array coil can be used to mitigate 7 T B0 inhomogeneity, which improves spectral quality and metabolite quantification over a whole-brain slab. Our results from simulations, phantoms, healthy and brain tumor human subjects indicate improvements of global B0 homogeneity by 55%, narrower spectral linewidth by 29%, higher signal-to-noise ratio by 31%, more precise metabolite quantification by 22%, and an increase by 21% of the brain volume that can be reliably analyzed. AC/DC shimming provide the highest correlation (R2 = 0.98, P = 0.001) with ground-truth values for metabolite concentration. Clinical translation of AC/DC and MRSI is demonstrated in a patient with mutant-IDH1 glioma where it enables imaging of D-2-hydroxyglutarate oncometabolite with a 2.8-fold increase in contrast-to-noise ratio at higher resolution and more brain coverage compared to previous 7 T studies. Hence, AC/DC technology may help ultra-high field MRSI become more feasible to take advantage of higher signal/contrast-to-noise in clinical applications
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