How Do We Know Anything? Philosophical Issues in the Collection and Interpretation of Operational Research Data

Measurement is a fundamental activity of science, but if we fail to make allowances for imponderables then we are simply generating data which may not, necessarily, tell us anything about the world. This chapter examines some of the philosophical underpinnings of Behavioral Operational Research by addressing three different levels of assumption. The first level is about the state of the world—what is actually out there. The second is about our ability to apprehend this—how we can actually know things and the limitations of the tools we have for investigating the world. The third level concerns knowledge and how we know things. This may seem abstract and esoteric, but it has fundamental implications for Operational Research. The philosophical assumptions underpinning the measurement of customer service, for example, may lead to very different conclusions about how customer service should be managed. It is only by exploring the philosophical underpinnings of our measurement that we can ensure that we measure things properly

Exchange effects on electron transport through single-electron spin-valve transistors

We study electron transport through single-electron spin-valve transistors in the presence of non-local exchange between the ferromagnetic leads and the central normal-metal island. The Coulomb interaction is described with the orthodox model for Coulomb blockade and we allow for noncollinear lead magnetization directions. Two distinct exchange mechanisms that have been discussed in the literature are shown to be of comparable strength and are taken into account on equal footing. We present results for the linear conductance as a function of gate voltage and magnetic configuration, and discuss the response of the system to applied magnetic fields.Comment: 15 pages, 6 figure

Industry-Academia Research toward Future Network Intelligence:The NG-CDI Prosperity Partnership

Ever since the first automation provided by the introduction of the Strowger telephone exchange in the late 19th century, networks have been increas- ingly automated. Fast forward to 2022, and the challenge facing network providers is scaling up this level of automation considering massive increases in complexity, new levels of agility to operate ser- vices, and rising demand from customers within the modern telecommunications ecosystem. This article describes a significant new industry-academia part- nership to address these challenges: Next Gener- ation Converged Digital Infrastructure (NG-CDI) is creating a vision for the building and operation of a future-proof network infrastructure and its autonomic management. In this article, we high- light three exemplar activities within the NG-CDI research program that illustrate the benefits of tak- ing a highly collaborative interdisciplinary approach and show how academia and industry working closely together have delivered a range of direct and positive impacts on business

Cassini RADAR Sequence Planning and Instrument Performance

The Cassini RADAR is a multimode instrument used to map the surface of Titan, the atmosphere of Saturn, the Saturn ring system, and to explore the properties of the icy satellites. Four different active mode bandwidths and a passive radiometer mode provide a wide range of flexibility in taking measurements. The scatterometer mode is used for real aperture imaging of Titan, high-altitude (around 20 000 km) synthetic aperture imaging of Titan and Iapetus, and long range (up to 700 000 km) detection of disk integrated albedos for satellites in the Saturn system. Two SAR modes are used for high- and medium-resolution (300-1000 m) imaging of Titan's surface during close flybys. A high-bandwidth altimeter mode is used for topographic profiling in selected areas with a range resolution of about 35 m. The passive radiometer mode is used to map emission from Titan, from Saturn's atmosphere, from the rings, and from the icy satellites. Repeated scans with differing polarizations using both active and passive data provide data that can usefully constrain models of surface composition and structure. The radar and radiometer receivers show very good stability, and calibration observations have provided an absolute calibration good to about 1.3 dB. Relative uncertainties within a pass and between passes can be even smaller. Data are currently being processed and delivered to the planetary data system at quarterly intervals one year after being acquired

Dynamic accommodation without feedback does not respond to isolated blur cues.

The aim of this study was to determine whether dynamic accommodation responds to isolated blur cues without feedback, and without changes in the distance of the object. Nine healthy subjects aged 21-40years were recruited. Four different aberration patterns were used as stimuli to induce blur with (1) the eye's natural, uncorrected, optical aberrations, (2) all aberrations corrected, (3) spherical aberration only, or (4) astigmatism only. The stimulus was a video animation based on computer-generated images of a monochromatic Maltese cross. Each individual video was generated for each subject off-line, after measuring individual aberrations at different accommodation levels. The video simulated sinusoidal changes in defocus at 0.2Hz. Dynamic images were observed through a 0.8mm pinhole placed at a plane conjugated with the eye's pupil, thus effectively removing potential feedback stemming from accommodation changes. Accommodation responses were measured with a Hartmann-Shack aberrometer for the four different aberration patterns. The results showed that seven out of nine subjects did not respond to any stimuli, whereas the response of the other two subjects was erratic and they seemed to be searching rather than following the stimulus. A significant reduction in average accommodative gain (from 0.52 to 0.11) was obtained when the dioptric demand cue was removed. No statistically significant differences were found among the experimental conditions used. We conclude that aberration related blur does not drive the accommodation response in the absence of feedback from accommodation

Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs: A computational study.

Atrial tachy-arrhytmias, such as atrial fibrillation (AF), are characterised by irregular electrical activity in the atria, generally associated with erratic excitation underlain by re-entrant scroll waves, fibrillatory conduction of multiple wavelets or rapid focal activity. Epidemiological studies have shown an increase in AF prevalence in the developed world associated with an ageing society, highlighting the need for effective treatment options. Catheter ablation therapy, commonly used in the treatment of AF, requires spatial information on atrial electrical excitation. The standard 12-lead electrocardiogram (ECG) provides a method for non-invasive identification of the presence of arrhythmia, due to irregularity in the ECG signal associated with atrial activation compared to sinus rhythm, but has limitations in providing specific spatial information. There is therefore a pressing need to develop novel methods to identify and locate the origin of arrhythmic excitation. Invasive methods provide direct information on atrial activity, but may induce clinical complications. Non-invasive methods avoid such complications, but their development presents a greater challenge due to the non-direct nature of monitoring. Algorithms based on the ECG signals in multiple leads (e.g. a 64-lead vest) may provide a viable approach. In this study, we used a biophysically detailed model of the human atria and torso to investigate the correlation between the morphology of the ECG signals from a 64-lead vest and the location of the origin of rapid atrial excitation arising from rapid focal activity and/or re-entrant scroll waves. A focus-location algorithm was then constructed from this correlation. The algorithm had success rates of 93% and 76% for correctly identifying the origin of focal and re-entrant excitation with a spatial resolution of 40 mm, respectively. The general approach allows its application to any multi-lead ECG system. This represents a significant extension to our previously developed algorithms to predict the AF origins in association with focal activities

ERRATUM: "DETERMINING TITAN'S SPIN STATE FROM CASSINI RADAR IMAGES" (2008, AJ, 135, 1669)

We previously reported an initial determination of Titan's rotational state from fits to overlapping radar images. We have since discovered a coding error in software used to make these fits, which led to systematic offsets of 1-2 km in recovered positions. While our principal results remain qualitatively unchanged, with this error corrected, the pole movement we previously reported (our weakest result) is now counterindicated. Our revised best fit is essentially the same as the "best-fit no pole wobble" result discussed at the top of the second column on page 1675. The determined pole location did not change significantly after the bug fix and thus we still conclude that the spin axis is not in the plane formed by Titan's orbit normal and the normal to the Laplace plane. Due to the correlations between pole wobble and spin rate (see Figure 3 on page 1672), the new best fit has a spin rate that differs from the synchronous value by an amount that is three times smaller than the value reported in the paper. The pole location changed by less than 0.01 deg (~500 m on the surface) and rate of increase in spin decreased by a factor of 2 from the previous fit. The new best-fit parameter values with 1σ error bars are: pole right ascension 39.4934 ± 0.0249 deg, pole declination 83.4368 ± 0.0024 deg, spin rate 22.57731 ± 0.00011 deg/day (0.00033 deg/day greater than synchronous spin rate), derivative of pole right ascension –6.52 ± 4.20 deg/century, derivative of pole declination –0.2212 ± 0.3567 deg/century, and derivative of spin rate 0.0247 ± 0.0050 deg/day/century. The corrected version of Table 3 (below) shows the residual systematic and random error of the several candidate models discussed in the paper. Fixing the bug reduced the residual systematic error of all the fitted models. The four models in which spin rate is allowed to vary from synchronous either due to a change in spin rate (Column 5, numbered from the left) or a change in its time derivative (Column 6) or both (Columns 7 and 8) have lower residual systematic errors and thus better represent the data than do the purely synchronous fit (Column 3). For this reason, an asynchronous spin rate is still supported by the data, although efforts (e.g., Mitchell 2009) to quantitatively interpret the asynchroneity should take our revised determination into account. On the other hand, as depicted by Columns 7 and 8, allowing the pole movement terms to vary from the predicted (IAU Titan) values results in no significant improvement in the fit, thus large short-term pole movement is not supported by the data. In fact, the best-fit values and error bars for the pole movement are consistent with the long-term pole trends that were predicted prior to the Cassini mission

Promoting Independence Through quality dementia Care at Home (PITCH): a research protocol for a stepped-wedge cluster-randomised controlled trial

BACKGROUND: Home care service providers are increasingly supporting clients living with dementia. Targeted and comprehensive dementia-specific training for home care staff is necessary to meet this need. This study evaluates a training programme delivered to care staff (paid personal carers) of clients living with dementia at home. METHODS: This study is a pragmatic stepped-wedge cluster-randomised controlled trial (SW-CRT). Home care workers (HCWs) from seven home care service providers are grouped into 18 geographical clusters. Clusters are randomly assigned to intervention or control groups. The intervention group receives 7 h of a dementia education and upskilling programme (Promoting Independence Through quality dementia Care at Home [PITCH]) after baseline measures. The control group receives PITCH training 6 months after baseline measures. This approach will ensure that all participants are offered the program. Home care clients living with dementia are also invited to participate, as well as their family carers. The primary outcome measure is HCWs’ sense of competence in dementia care provision. DISCUSSION: Upskilling home care staff is needed to support the increasing numbers of people living with dementia who choose to remain at home. This study uses a stepped-wedge cluster-randomised trial to evaluate a training programme (PITCH) for dementia care that is delivered to front-line HCWs. TRIAL REGISTRATION: anzctr.org.au; ACTRN12619000251123. Registered on 20 February 2019

Safety and Immunogenicity Study of Multiclade HIV-1 Adenoviral Vector Vaccine Alone or as Boost following a Multiclade HIV-1 DNA Vaccine in Africa

We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector expressing HIV-1 Gag and Pol from subtype B and Env from subtypes A, B and C, given alone or as boost following a DNA plasmid vaccine expressing the same HIV-1 proteins plus Nef, in 114 healthy HIV-uninfected African adults.Volunteers were randomized to 4 groups receiving the rAd5 vaccine intramuscularly at dosage levels of 1×10(10) or 1×10(11) particle units (PU) either alone or as boost following 3 injections of the DNA vaccine given at 4 mg/dose intramuscularly by needle-free injection using Biojector® 2000. Safety and immunogenicity were evaluated for 12 months. Both vaccines were well-tolerated. Overall, 62% and 86% of vaccine recipients in the rAd5 alone and DNA prime - rAd5 boost groups, respectively, responded to the HIV-1 proteins by an interferon-gamma (IFN-γ) ELISPOT. The frequency of immune responses was independent of rAd5 dosage levels. The highest frequency of responses after rAd5 alone was detected at 6 weeks; after DNA prime - rAd5 boost, at 6 months (end of study). At baseline, neutralizing antibodies against Ad5 were present in 81% of volunteers; the distribution was similar across the 4 groups. Pre-existing immunity to Ad5 did not appear to have a significant impact on reactogenicity or immune response rates to HIV antigens by IFN-γ ELISPOT. Binding antibodies against Env were detected in up to 100% recipients of DNA prime - rAd5 boost. One volunteer acquired HIV infection after the study ended, two years after receipt of rAd5 alone.The HIV-1 rAd5 vaccine, either alone or as a boost following HIV-1 DNA vaccine, was well-tolerated and immunogenic in African adults. DNA priming increased the frequency and magnitude of cellular and humoral immune responses, but there was no effect of rAd5 dosage on immunogenicity endpoints.ClinicalTrials.gov NCT00124007