BariSurg trial: Sleeve gastrectomy versus Roux-en-Y gastric bypass in obese patients with BMI 35–60 kg/m2 – a multi-centre randomized patient and observer blind non-inferiority trial

Background: Roux-en-Ygastric bypass (RYGB) and sleeve gastrectomy (SG) rank among the most frequently applied bariatric procedures worldwide due to their positive risk/benefit correlation. A systematic review revealed a similar excess weight loss (EWL) 2 years postoperatively between SG and RYGB. However, there is a lack of randomized controlled multi-centre trials comparing SG and RYGB, not only concerning EWL, but also in terms of remission of obesity-related co-morbidities, gastroesophageal reflux disease (GERD) and quality of life (QoL) in the mid- and long-term. Methods: The BariSurg trial was designed as a multi-centre, randomized controlled patient and observer blind trial. The trial protocol was approved by the corresponding ethics committees of the centres. To demonstrate EWL non-inferiority of SG compared to RYGB, power calculation was performed according to a non-inferiority study design. Morbidity, mortality, remission of obesity-related co-morbidities, GERD course and QoL are major secondary endpoints. 248 patients between 18 and 70 years, with a body mass index (BMI) between 35–60 kg/m2 and indication for bariatric surgery according to the most recent German S3-guidelines will be randomized. The primary and secondary endpoints will be assessed prior to surgery and afterwards at discharge and at the time points 3–6, 12, 24, 36, 48 and 60 months postoperatively. Discussion: With its five year follow-up, the BariSurg-trial will provide further evidence based data concerning the impact of SG and RYGB on EWL, remission of obesity-related co-morbidities, the course of GERD and QoL. Trial registration: The trial protocol has been registered in the German Clinical Trials Register DRKS0000476

Die Pruefung der Umweltvertraeglichkeit (Beruecksichtigung von Umweltbelangen) bei der Ansiedlung von Industrie- und Gewerbebetrieben im Rahmen der regionalen Wirtschaftsfoerderung: e. empir. Analyse

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Symphonie N ° 9 en ré mineur : avec Choeurs, op. 125 / Beethoven, comp. ; Teresa Stich-Randall, S ; Lore Fischer, A ; Ferdinand Koch, T ; orchestre symphonique et choeurs du Gurzenich de Cologne ; Günter Wand, dir.

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Cantate n ° 51 "JAUCHZET GOTT IN ALLEN LANDEN" pour le 15ème dimanche après la Trinité / Jean-Sébastien Bach ; Theresa Stich-Randall, soprano ; Helmut Wobisch, trompette ; Rudolf Streng et Wilhelm Hubner, violons ; Joseph Nebois, clavecin et orgue ; avec l'Orchestre de l'Opéra de Vienne dir. Anton Heiller. Cantate n ° 209 "NON SA CHE SIA DOLORE" : (Les Adieux) / Jean-Sébastien Bach ; Theresa Stich Randall, soprano ; Hans Reznicek, flûte ; Joseph Nebois, clavecin avec l'Orchestre de l'Opéra de Vienne dir. Anton Heiller

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MISSA IN ANGUSTIIS : Messe de Lord Nelson, en ré mineur / Josef Haydn ; les solistes : Theresa Stich-Randall, Soprano ; Rudolf Schock, Ténor Mona Paulée, Mezzo soprano ; Gottlob Frick, basse ; Choeurs de musique sacrée du Conservatoire et orchestre de l'Opéra de Vienne, sous la dir. de Jonathan Sternberg

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