The role of negative urgency in risky alcohol drinking and binge-eating in United Kingdom male and female students

Identifying students at risk of developing binge-eating and alcohol use disorders is a priority in the United Kingdom (UK). Although relationships between negative urgency (impulsive behavior during times of negative emotion), risky drinking, and binge-eating have been established in students from other countries, these links have yet to be replicated in male and female UK students. UK students aged 18–30 (n = 155) completed the: (1) the Urgency, Pre-meditation, Perseverance, Sensation Seeking (UPPS-P) negative urgency subscale; (2) Alcohol Use Disorders Identification Test (AUDIT); and (3) Binge-Eating Scale (BES). For categorical analysis, participants were assigned to one of four groups as a function of AUDIT and BES clinical cut-off scores: (1) no risk (28%); (2) risky drinkers (47%); (3) binge-eaters (6%); and (4) risky drinkers + binge-eaters (19%). For dimensional analysis, across students with non-zero AUDIT and BES scores (n = 141), BES, AUDIT, gender, and their interactions were entered as predictors in the same block of a regression. UPPS-P negative urgency was the dependent variable. Categorical results indicated that binge-eaters with and without risky drinking endorsed significantly higher negative urgency than students with no risk. Dimensional results showed that although higher BES and AUDIT scores were positively linked to higher negative urgency, but only the BES was significantly associated. Furthermore, BES shared substantially more variance with negative urgency than the AUDIT, and the BES-negative urgency relationship was stronger in male students than female students. High risk students may benefit the most from interventions that help regulate negative emotion

A Mouse Amidase Specific for N-terminal Asparagine: the gene, the enzyme, and their function in the N-end rule pathway

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In both fungi and mammals, the tertiary destabilizing N-terminal residues asparagine and glutamine function through their conversion, by enzymatic deamidation, into the secondary destabilizing residues aspartate and glutamate, whose destabilizing activity requires their enzymatic conjugation to arginine, one of the primary destabilizing residues. We report the isolation and analysis of a mouse cDNA and the corresponding gene (termed Ntan1) that encode a 310-residue amidohydrolase (termed NtN-amidase) specific for N-terminal asparagine. The ~17-kilobase pair Ntan1 gene is located in the proximal region of mouse chromosome 16 and contains 10 exons ranging from 54 to 177 base pairs in length. The ~1.4-kilobase pair Ntan1 mRNA is expressed in all of the tested mouse tissues and cell lines and is down-regulated upon the conversion of myoblasts into myotubes. The Ntan1 promoter is located ~500 base pairs upstream of the Ntan1 start codon. The deduced amino acid sequence of mouse NtN-amidase is 88% identical to the sequence of its porcine counterpart, but bears no significant similarity to the sequence of the NTA1-encoded N-terminal amidohydrolase of the yeast Saccharomyces cerevisiae, which can deamidate either N-terminal asparagine or glutamine. The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule. Further dissection of mouse Ntan1, including its null phenotype analysis, should illuminate the functions of the N-end rule, most of which are still unknown

Surgical management of giant Brunner's gland hamartoma: case report and literature review

Brunner's gland hamartomas (BGH) are uncommon benign tumors of the duodenum forming mature Brunner's glands. We report here an unusual case of a giant BGH that was not amenable to endoscopic or surgical local resection thus requiring a pancreaticoduodenectomy for extirpation. The relevant literature is discussed

Tunneling Via Individual Electronic States in Ferromagnetic Nanoparticles

We measure electron tunneling via discrete energy levels in ferromagnetic cobalt particles less than 4 nm in diameter, using non-magnetic electrodes. Due to magnetic anisotropy, the energy of each tunneling resonance shifts as an applied magnetic field rotates the particle's magnetic moment. We see both spin-increasing and decreasing tunneling transitions, but we do not observe the spin degeneracy at small magnetic fields seen previously in non-magnetic materials. The tunneling spectrum is denser than predicted for independent electrons, possibly due to spin-wave excitations.Comment: 4 pages, 4 figures. Improved by comments from referees, to appear in Phys. Rev. Let

Mesoscopic fluctuations of the ground state spin of a small metal particle

We study the statistical distribution of the ground state spin for an ensemble of small metallic grains, using a random-matrix toy model. Using the Hartree Fock approximation, we find that already for interaction strengths well below the Stoner criterion there is an appreciable probability that the ground state has a finite, nonzero spin. Possible relations to experiments are discussed.Comment: 4 pages, RevTeX; 1 figure included with eps

The Ursinus Weekly, November 13, 1950

Fraternities fete, bid men during week of rushing • First movies of year, Little Men, Great Guns, to be shown on Friday • Debaters to oppose Swarthmore varsity • Lantern asks students for Fall issue material • Herbsleb to address IRC Tuesday on international law topic • Chi Alpha to meet Tuesday • 51\u27ers assume commercial name • Smith tells Forum of status of Britain in trade, economy • Ruby launches campaigns for photography and selling • Student authored, produced Dusty Halo receives plaudits • YM-YW conducts WSSF and toy-clothing drives • Harris stresses need of developing maturity in religious matters • Dorm at 724 Main wins spirit trophy • Sophs to send gift to injured classmate • Big Sisters hold party • Editorials: Case against apathy; Challenge to our intellect • Class idiosyncrasies bared • Scribe pens WSGA notes • Drum majorettes use many maneuvers, combine long experience and ingenuity • Committee heads announced for Curtain Club Fall production • MSGA to cut mealtime announcements, substitute rebuilt outdoor bulletin board • Newman Club holds banquet • Beaver falls 3-2 to hockey squad; Boyd paces team • Jay-Vees triumph 6-1 over Beaver JV squad • Bruins to oppose Crusaders eleven at Selinsgrove • Grizzlies bow 3-0 to Lehigh booters • Undefeated Derr cops intramural grid title • Panthers build early lead to conquer Bruins 13-6 • St. Joseph\u27s takes cross-country meet • Cheer and comfort for the weary, tale of mid-semester\u27s evil birth • Weekly sports poll reveals majority wants powerhouse intercollegiate teamhttps://digitalcommons.ursinus.edu/weekly/1552/thumbnail.jp