La castrametation

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 2009Marca tip. en portSign.: []\p3\s, A-G\p4\sIlustraciones calc., retrato del autor y croquis de organizació

Nouvelle maniere de fortification par escluses

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 2009Marca tip. en portSign.: []\p2\s, A-H\p4\s, I\p2\sIlustraciones xil., dibujos de construcció

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s disease, and experimental data have demonstrated microglial proliferation as a significant component of the neuropathology. In this study, we tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 (JNJ-527) in the P301S mouse tauopathy model. We first demonstrated the anti-proliferative effects of JNJ-527 on microglia in the ME7 prion model, and its impact on the inflammatory profile, and provided potential CNS biomarkers for clinical investigation with the compound, including pharmacokinetic/pharmacodynamics and efficacy assessment by TSPO autoradiography and CSF proteomics. Then, we showed for the first time that blockade of microglial proliferation and modification of microglial phenotype leads to an attenuation of tau-induced neurodegeneration and results in functional improvement in P301S mice. Overall, this work strongly supports the potential for inhibition of CSF1R as a target for the treatment of Alzheimer’s disease and other tau-mediated neurodegenerative diseases

Inflammatory biomarkers in Alzheimer's disease plasma

Introduction:Plasma biomarkers for Alzheimer’s disease (AD) diagnosis/stratification are a“Holy Grail” of AD research and intensively sought; however, there are no well-established plasmamarkers.Methods:A hypothesis-led plasma biomarker search was conducted in the context of internationalmulticenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL;259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed.Results:Ten analytes showed significant intergroup differences. Logistic regression identified five(FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APOε4 adjusted, optimally differentiated AD andCTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI(AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Twoanalytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71).Discussion:Plasma markers of inflammation and complement dysregulation support diagnosis andoutcome prediction in AD and MCI. Further replication is needed before clinical translatio

La pratiqve d'arithmetiqve

de Simon Stevin de BrvgesHandschriftliches Exlibris: "Paul Stopp?

Appendice

Au lecteur L’imprimeur m’ayant fait savoir qu’il avait l’intention d’imprimer à nouveau la Burgherlick leven et m’ayant demandé si je voulais y ajouter quelque chose pour élargir les dimensions de ce petit livre, je lui ai fait parvenir l’argument [strijtredens / argumenta] suivant touchant cette question [gheschil / quaestio] ancienne et générale, qui est de savoir si l’on doit, pour gouverner de la meilleure façon, mêler la vertu au vice, ou si l’on doit la garder pure de toute contaminatio..

L' arithmétiqve : contenant les computations des nombres arithmetiques ou vulgaires: aussi l'algebre, avec les equations de cinc quantitez. : ensemble les quatre premiers liures d'algebre de Diophante d'Alexandrie...

de Simon Stevin de BrvgesS. 369-384 fehlenBogensignaturen: *8, **4, A-Z8, b-s8, Aa-Nn8, Oo

La castrametation : selon l'ordonnance & usage de très-illustre, très-excellent Prince et Seigneur Maurice, par la grace de Dieu Prince d'Orange, Comte de Nassau, Catzenellenbogen, Vianden, Diets, Lingen, Moers, Bure, Leerdam, Marquis de la Vere, & de Flissingues, Seigneur & Baron de Breda, de la Ville de Grave, & du Païs de Cuyck, Diest, Grimbergues, Arlay, Noseroy, &c. Viconte Hereditaire d'Anvers, & Besançon, Gouverneur, Capitaine General, & Admirael des Provinces unies, Chevalier de l'Ordre de la Iartiere, &c

descrite par Symon Stevin de Bruge