Smoking and Mortality Among US Astronauts

Astronauts have lower age-specific mortality risk than the U.S. general population from all natural causes of death, particularly cardiovascular disease and cancer. Yet, understanding if they are as healthy as their backgrounds predict they should be, requires that epidemiologists understand (and measure) all potentially confounding exposures in this cohort. Tobacco smoking prevalence has been measured in the U.S. astronaut cohort, but its impact on mortality has not been previously assessed. If smoking history has a negative impact on mortality, this could confound attempts to measure the relative health of astronauts

Cationic Alkylaluminum-Complexed Zirconocene Hydrides: NMR-Spectroscopic Identification, Crystallographic Structure Determination, and Interconversion with Other Zirconocene Cations

The ansa-zirconocene complex rac-Me_2Si(1-indenyl)_2ZrCl_2 ((SBI)ZrCl_2) reacts with diisobutylaluminum hydride and trityl tetrakis(perfluorophenyl)borate in hydrocarbon solutions to give the cation [(SBI)Zr(μ-H)_3(Al^iBu_2)_2]^+, the identity of which is derived from NMR data and supported by a crystallographic structure determination. Analogous reactions proceed with many other zirconocene dichloride complexes. [(SBI)Zr(μ-H)_3(Al^iBu2)_2]^+ reacts reversibly with ClAl^iBu_2 to give the dichloro-bridged cation [(SBI)Zr(μ-Cl)_2Al^iBu_2]^+. Reaction with AlMe_3 first leads to mixed-alkyl species [(SBI)Zr(μ-H)_3(AlMe_x^iBu_(2−x))_2^]+ by exchange of alkyl groups between aluminum centers. At higher AlMe_3/Zr ratios, [(SBI)Zr(μ-Me)_2AlMe_2]^+, a constituent of methylalumoxane-activated catalyst systems, is formed in an equilibrium, in which the hydride cation [(SBI)Zr(μ-H)_3(AlR_2)_2]^+ strongly predominates at comparable HAl^iBu_2 and AlMe_3 concentrations, thus implicating the presence of this hydride cation in olefin polymerization catalyst systems

The Mortality of Space Explorers

Outer space exploration poses unique risks to human survival. Here, we review the current literature on United States astronauts and Soviet and Russian cosmonauts and provide updated and original research findings. As in previous research, both astronauts and cosmonauts are shown to have reduced risk of death by natural causes, particularly from chronic diseases such as cardiovascular disease and cancer, compared with appropriately matched general populations. Simultaneously, space explorers are at increased risk of death by external forces, particularly accidents such as plane crashes and spacecraft accidents. In total, both astronauts and cosmonauts are at reduced risk of all-cause mortality in comparison to the general populations of the United States and Russia. However, in comparison to astronauts, cosmonauts have been at equal risk of accidental death, but increased risk of death by chronic disease. We conjecture that the lack of risk from chronic disease may be due to the excellent health and medical monitoring of space explorers coupled with the deliberate attempts to limit their radiation exposure levels below those that would be detrimental. The differences in the astronaut and cosmonaut mortality experiences are likely due to lifestyle factors and the background rates of mortality in the two nations

Mortality of major league baseball players from Canada, Latin America, and the Caribbean

Professional baseball players have lower mortality rates than the US general population, but whether this is true of foreign-born players is not known. Using data on ballplayers from six nations, we compare mortality rates with those of US players via standardized mortality ratios. After controlling for confounders, four countries had statistically insignificant SMRs while two nations had significantly elevated SMRs. In the two nations with elevated SMRs, low average ages at death and high crime rates suggest the increased mortality may be linked to violent crime. A full understanding of the causes of disparity in mortality will require further research

Survival, Mortality, and Life Expectancy

Cerebral palsy (CP) is a heterogenous condition, with level of disability ranging from immaterial to profound. In concert with the continuum of level of severity of disability/independent functioning, health care needs, therapies, medications, surgical interventions, costs of care, daily demands on parents and other family members, and expectations for the future in terms of education, employment, and other milestones of life all vary widely. Similarly, life expectancy in CP follows a continuum, from far lower than to potentially as high as general population life expectancy, that parallels the continuum of levels of disability. Here we review the literature documenting this, and examine the specific factors that are known to be strongly associated with mortality and longevity in CP. We also examine the evidence regarding causes of death in CP, and present some new findings related to this. Finally, we outline important methodological considerations for future research in this area

Adjoint analysis of the source and path sensitivities of basin-guided waves

Simulations of earthquake rupture on the southern San Andreas Fault (SAF) reveal large amplifications in the San Gabriel and Los Angeles Basins (SGB and LAB) apparently associated with long-range path effects. Geometrically similar excitation patterns can be recognized repeatedly in different SAF simulations (e.g. Love wave-like energy with predominant period around 4 s, channelled southwestwardly from the SGB into LAB), yet the amplitudes with which these distinctive wavefield patterns are excited change, depending upon source details (slip distribution, direction and velocity of rupture). We describe a method for rapid calculation of the sensitivity of such predicted wavefield features to perturbations of the source kinematics, using a time-reversed (adjoint) wavefield simulation. The calculations are analogous to those done in adjoint tomography, and the same time-reversed calculation also yields path-sensitivity kernels that give further insight into the excitation mechanism. For rupture on the southernmost 300 km of SAF, LAB excitation is greatest for slip concentrated between the northern Coachella Valley and the transverse ranges, propagating to the NE and with rupture velocities between 3250 and 3500 m s-1 along that fault segment; that is, within or slightly above the velocity range (between Rayleigh and S velocities) that is energetically precluded in the limit of a sharp rupture front, highlighting the potential value of imposing physical constraints (such as from spontaneous rupture models) on source parametrizations. LAB excitation is weak for rupture to the SW and for ruptures in either direction located north of the transverse transverse ranges, whereas Ventura Basin (VTB) is preferentially excited by NE ruptures situated north of the transverse ranges. Path kernels show that LAB excitation is mediated by surface waves deflected by the velocity contrast along the southern margin of the transverse ranges, having most of their energy in basement rock until they impinge on the eastern edge of SGB, through which they are then funnelled into LAB. VTB amplification is enhanced by a similar waveguide effec

Integrated Block Sharing: A Win–Win Strategy for Hospitals and Surgeons

We consider the problem of balancing two competing objectives in the pursuit of efficient management of operating rooms in a hospital: providing surgeons with predictable, reliable access to the operating room and maintaining high utilization of capacity. The common solution to the first problem (in practice) is to grant exclusive “block time,” in which a portion of the week in an operating room is designated to a particular surgeon, barring other surgeons from using this room/time. As a major improvement over this existing approach, we model the possibility of “shared” block time, which need only satisfy capacity constraints in expectation. We reduce the computational difficulty of the resulting NP-hard block-scheduling problem by implementing a column-generation approach and demonstrate the efficacy of this technique using simulation, calibrated to a real hospital’s historical data and objectives. Our simulations illustrate substantial benefits to hospitals under a variety of circumstances and demonstrate the advantages of our new approach relative to a benchmark method taken from the recent literature

Theories of developmental dyslexia: Insights from a multiple case study of dyslexic adults

A multiple case study was conducted in order to assess three leading theories of developmental dyslexia: the phonological, the magnocellular (auditory and visual) and the cerebellar theories. Sixteen dyslexic and 16 control university students were administered a full battery of psychometric, phonological, auditory, visual and cerebellar tests. Individual data reveal that all 16 dyslexics suffer from a phonological deficit, 10 from an auditory deficit, 4 from a motor deficit, and 2 from a visual magnocellular deficit. Results suggest that a phonological deficit can appear in the absence of any other sensory or motor disorder, and is sufficient to cause a literacy impairment, as demonstrated by 5 of the dyslexics. Auditory disorders, when present, aggravate the phonological deficit, hence the literacy impairment. However, auditory deficits cannot be characterised simply as rapid auditory processing problems, as would be predicted by the magnocellular theory. Nor are they restricted to speech. Contrary to the cerebellar theory, we find little support for the notion that motor impairments, when found, have a cerebellar origin, or reflect an automaticity deficit. Overall, the present data support the phonological theory of dyslexia, while acknowledging the presence of additional sensory and motor disorders in certain individuals

Comparison of finite difference and boundary integral solutions to three-dimensional spontaneous rupture

The spontaneously propagating shear crack on a frictional interface has proven to be a useful idealization of a natural earthquake. The corresponding boundary value problems are nonlinear and usually require computationally intensive numerical methods for their solution. Assessing the convergence and accuracy of the numerical methods is challenging, as we lack appropriate analytical solutions for comparison. As a complement to other methods of assessment, we compare solutions obtained by two independent numerical methods, a finite difference method and a boundary integral (BI) method. The finite difference implementation, called DFM, uses a traction-at-split-node formulation of the fault discontinuity. The BI implementation employs spectral representation of the stress transfer functional. The three-dimensional (3-D) test problem involves spontaneous rupture spreading on a planar interface governed by linear slip-weakening friction that essentially defines a cohesive law. To get a priori understanding of the spatial resolution that would be required in this and similar problems, we review and combine some simple estimates of the cohesive zone sizes which correspond quite well to the sizes observed in simulations. We have assessed agreement between the methods in terms of the RMS differences in rupture time, final slip, and peak slip rate and related these to median and minimum measures of the cohesive zone resolution observed in the numerical solutions. The BI and DFM methods give virtually indistinguishable solutions to the 3-D spontaneous rupture test problem when their grid spacing Δx is small enough so that the solutions adequately resolve the cohesive zone, with at least three points for BI and at least five node points for DFM. Furthermore, grid-dependent differences in the results, for each of the two methods taken separately, decay as a power law in Δx, with the same convergence rate for each method, the calculations apparently converging to a common, grid interval invariant solution. This result provides strong evidence for the accuracy of both methods. In addition, the specific solution presented here, by virtue of being demonstrably grid-independent and consistent between two very different numerical methods, may prove useful for testing new numerical methods for spontaneous rupture problems