Cybercrime precursors: towards a model of offender resources

This thesis applies Ekblom and Tilley’s concept of offender resources to the study of criminal behaviour on the Internet. Offender predispositions are influenced by situational, that is the environmental incentives to commit crime. This thesis employs non-participation observation of online communities involved in activities linked to malicious forms of software. Actual online conversations are reproduced, providing rich ethnographic detail of activities that have taken place between 2008 and 2012 from eight discussion forums where malicious software and cases of hacking are openly discussed among actors. A purposeful sample of key frontline cybercrime responders (N=12) were interviewed about crimeware and their views of the activity observed in the discussion forums. Based on the empirical data, this thesis tests a number of criminological theories and assesses their relative compatibility with social interactions occurring in various online forum sites frequented by persons interested in the formation and use of malicious code. The thesis illustrates three conceptual frameworks of offender resources, based on different criminological theories. The first model ties ‘offender resources’ to the actual offender, suggesting that certain malicious software and its associated activities derive from the decisions, knowledge and abilities of the individual agent. The second model submits that ‘offender resources’ should be viewed more as a pathway leading to offending behaviour that must be instilled and then indoctrinated over a length of time through social interaction with other offenders. The third model emphasises the complex relationships that constitute or interconnect with ‘offender resources’ such as the nexus of relevant social groups and institutions in society. These include the Internet security industry, the law, and organised crime. Cybercrime is facilitated by crimeware, a specific type of computer software, and a focus on this element can help better understand how cybercrime evolves

The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study

Objective To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation. Patients and Methods This was an international multicentre prospective observational study. We included patients aged ≥16 years, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex, and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals, and countries. Results Of the 11 059 patients assessed for eligibility, 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3–34.1), bladder cancer (n = 1951) 24.7% (95% CI 19.1–30.2), UTUC (n = 128) 1.14% (95% CI 0.77–1.52), renal cancer (n = 107) 1.05% (95% CI 0.80–1.29), and prostate cancer (n = 124) 1.75% (95% CI 1.32–2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03–1.05; P < 0.001), visible haematuria 3.47 (95% CI 2.90–4.15; P < 0.001), male sex 1.30 (95% CI 1.14–1.50; P < 0.001), and smoking 2.70 (95% CI 2.30–3.18; P < 0.001). Conclusions A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care, adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer

Organizations and cyber crime : an analysis of the nature of groups engaged in cyber crime

This paper explores the nature of groups engaged in cyber crime. It briefly outlines the definition and scope of cyber crime, theoretical and empirical challenges in addressing what is known about cyber offenders, and the likely role of organized crime groups. The paper gives examples of known cases that illustrate individual and group behaviour, and motivations of typical offenders, including state actors. Different types of cyber crime and different forms of criminal organization are described drawing on the typology suggested by McGuire (2012). It is apparent that a wide variety of organizational structures are involved in cyber crime. Enterprise or profit-oriented activities, and especially cyber crime committed by state actors, appear to require leadership, structure, and specialisation. By contrast, protest activity tends to be less organized, with weak (if any) chain of command.20 page(s

Spontaneous, unriitting gross hematuria occurring one week after laparoscopic donor nephrectomy

Complications associated with the ureteral stump after nephrectomies rarely occur, especially after donor nephrectomies. The potential for the slippage of clips is a well-known event associated with vascular ligations. We report on the first case of clip slippage from the ureter and describe diagnosis and managient of the most extrie of morbid presentations

Correction: Chon-Kit Chou, et al. The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases. Int. J. Mol. Sci. 2017, 18, 483

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The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases

Deubiquitinases (DUBs) play a critical role in ubiquitin-directed signaling by catalytically removing the ubiquitin from substrate proteins. Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (His) boxes. USP15 harbors two zinc-binding motifs that are essential for recognition of poly-ubiquitin chains. USP15 is grouped into the same category with USP4 and USP11 due to high degree of homology in an N-terminal region consisting of domains present in ubiquitin-specific proteases (DUSP) domain and ubiquitin-like (UBL) domain. USP15 cooperates with COP9 signalosome complex (CSN) to maintain the stability of cullin-ring ligase (CRL) adaptor proteins by removing the conjugated ubiquitin chains from RBX1 subunit of CRL. USP15 is also implicated in the stabilization of the human papillomavirus type 16 E6 oncoprotein, adenomatous polyposis coli, and IκBα. Recently, reports have suggested that USP15 acts as a key regulator of TGF-β receptor-signaling pathways by deubiquitinating the TGF-β receptor itself and its downstream transducers receptor-regulated SMADs (R-SMADs), including SMAD1, SMAD2, and SMAD3, thus activating the TGF-β target genes. Although the importance of USP15 in pathologic processes remains ambiguous so far, in this review, we endeavor to summarize the literature regarding the relationship of the deubiquitinating action of USP15 with the proteins involved in the regulation of Parkinson’s disease, virus infection, and cancer-related signaling networks